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Protein Overview: Cyp313a2-PA

General Information:
Name(s) found: Cyp313a2-PA / FBpp0082087 [FlyBase]
Description(s) found:
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  • gi|33302607|sp|Q9VGB4.3|CP132_DROME RecName: Full=Probable cytochrome P450 313a2; AltName: Full=CYPCCCXIIIA2 [NCBI NR]
  • gi|24646219|ref|NP_650169.2| Cyp313a2 [Drosophila melanogaster] [NCBI NR]
  • gi|23171089|gb|AAF54769.3| Cyp313a2 [Drosophila melanogaster] [NCBI NR]
  • Probable cytochrome P450 313a2 OS=Drosophila melanogaster GN=Cyp313a2 PE=3 SV=3 [Swiss-Prot]
  • (Q9VGB4) Probable cytochrome P450 313a2 (EC 1.14.-.-) (CYPCCCXIIIA2) [Swiss-Prot]
  • The gene Cyp313a2 is referred to in FlyBase by the symbol Dmel\Cyp313a2 (CG10094, FBgn0038006). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:8060792..8062621. It has the cytological map location 87B3. Based on sequence similarity, it is predicted to have molecular function</span>: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG10094-PA translation from_gene[CG10094 Cyp313a2 FBgn0038006] seq_release:3 mol_weight=56624 cds_boundaries:(3R:8,060,814..8,062,640[-]) aa_length:493 transcript_info:[CG10094-RA seq_release:3] gene_info:[gene symbol:Cyp313a2 FBgn0038006 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • CG10094-PA [Drosophila melanogaster]gi|24646219|ref|NP_650169.2| CG10094-PA [Drosophila melanogaster]gi|33302607|sp|Q9VGB4|C132_DROME Probable cytochrome P450 313a2 (CYPCCCXIIIA2) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(8060792..8060955,8061029..8061602,8061656..8061782,8061843..8061915,8061971..8062156,8062208..8062404,8062461..8062621); ID=FBpp0082087; name=Cyp313a2-PA; parent=FBgn0038006,FBtr0082618; dbxref=FlyBase:FBpp0082087,FlyBase_A [fly-100309-contam.fasta]
  • CG10094-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Probable cytochrome P450 313a2 (CYPCCCXIIIA2) [nr-271106-contam.fasta]
  • Cyp313a2 CG10094-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(8060792..8060955,8061029..8061602,8061656..8061782,8061843..8061915,8061971..8062156,8062208..8062404,8062461..8062621); ID=FBpp0082087; name=Cyp313a2-PA; parent=FBgn0038006,FBtr0082618; dbxref=FlyBase:FBpp0082087,FlyBase_Annotation_IDs:CG10094-PA,GB_protein:AAF54769.3,REFSEQ:NP_650169,GB_protein:AAF54769; MD5=31312eea2aa5226eb719c3c1c1ca2a8a; length=493; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(8060792..8060955,8061029..8061602,8061656..8061782,8061843..8061915,8061971..8062156,8062208..8062404,8062461..8062621); ID=FBpp0082087; name=Cyp313a2-PA; parent=FBgn0038006,FBtr0082618; dbxref=FlyBase:FBpp0082087,FlyBase_Annotation_IDs:CG10094-PA,GB_protein:AAF54769.3,REFSEQ:NP_650169,GB_protein:AAF54769; MD5=31312eea2aa5226eb719c3c1c1ca2a8a; length=493; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
    • Organism: Drosophila melanogaster
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVIQLLIAA SLILWIRFLW SRRKLYMLMM QLPGRMGLPL LGNSVRYLII SRGKMSSRTT  60
   61 YMDKHGSTYM AWIGTTPIVI TRDPKIAEKV LTSPFCINRS SQTTNALALS MGYGLLTLQG 120
  121 SKWMARRKHM NPAFKHSVLL SFLPIFNAET DLLVSVFDSF VGQGEKDVLS DLIRWSFAIA 180
  181 TQTTLGTDVT KDDNFENDAI LKTYQSMLRL TIINIFVPFV QNKIVSKLFG LEWLRRRDAS 240
  241 AINKMINNIL DKKLNSNPEN YCESELKTVI HRAIELFRND EMSLMELGAE CSSMVLAAFE 300
  301 TSAHTVYYAL VLLAMFPEHQ EMVFNEIKEH FPLAKGIEVT HTDLQQLVYL DRVLNETLRL 360
  361 MPSVPFSSRE TLEDLRLSNG VVIPKGMTIS IDIFNTQRNT DYWGSEAAQF NPENFLPEKI 420
  421 HDRHPYAFIP FSKGKRNCIG WRYGLMSSKL ALVKILRNYK LKTSFPYENL EFVDHMVIKL 480
  481 AQSPQLAFER RTL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..493] PSI-BLAST 95.30103 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxygen binding
    		•  3.7203678182299 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • fluorene oxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • retinoic acid binding
    		•  3.04897926497756 bayes_pls_golite062009
  • demethylase activity
    		•  2.80780658333504 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.33937429425924 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  2.30416050662077 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  1.65569090470706 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  1.46109575978397 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • protein binding
    		•  0.836411857417911 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • iron ion binding
    		•  0.529598228513719 bayes_pls_golite062009
  • cation binding
    		•  0.510556740388808 bayes_pls_golite062009
  • metal ion binding
    		•  0.510556740388808 bayes_pls_golite062009
  • ion binding
    		•  0.503326724714616 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.450436868179747 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  0.0888154993183798 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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