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Protein Overview: slik-PD, slik-PB

General Information:
Name(s) found: slik-PD / FBpp0072273 [FlyBase]
slik-PB / FBpp0072271 [FlyBase]
Description(s) found:
Found 37 descriptions.
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  • The gene Sterile20-like kinase is referred to in FlyBase by the symbol Dmel\slik (CG4527, FBgn0035001). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20279652..20290245. It has the cytological map location 60C7-60C8. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of peptidyl-threonine phosphorylation; cell proliferation; protein amino acid phosphorylation; cytokinesis; regulation of localization. 19 alleles are reported. The phenotypes of these alleles are annotated with: 1st posterior cell; peripodial epithelium; wing. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Sterile20-like kinase is referred to in FlyBase by the symbol Dmel\slik (CG4527, FBgn0035001). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20279652..20290245. It has the cytological map location 60C7-60C8. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of peptidyl-threonine phosphorylation; cell proliferation; protein amino acid phosphorylation; cytokinesis; regulation of localization. 19 alleles are reported. The phenotypes of these alleles are annotated with: 1st posterior cell; peripodial epithelium; wing. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1703 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: cell proliferation [IMP]
    regulation of localization [IMP]
    cytokinesis [IMP]
    positive regulation of peptidyl-threonine phosphorylation [IMP]
    protein amino acid phosphorylation [IDA][NAS]
    Molecular Function: polo kinase kinase activity [NAS]
    ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [ISS][NAS]
    protein serine/threonine kinase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFITNLKKV FHLGGGEAKK KRLYNNIKMD TDPAEFWEMV GELGDGAFGK VYKAQHKEQK  60
   61 RFAAAKMCQL EDEENLSDHM VEIDILSEIK HPNIVELYEA FSIDDKLWML IEYCDGGALD 120
  121 SIMVELEKPL TEPQIAYVCK HMTEGLTFLH RNKVIHRDLK AGNVLLTMEG GVKLADFGVS 180
  181 AKNKHTMQKH DTFIGTPYWM APELVLCETF RDNPYDHKVD IWSLGITLIE LAQMEPPNSE 240
  241 MSPMRVLLKI QKSEPPKLEQ PSRWSKEFND FLKKSLVKDP QVRPTTDVLM QHAFINRNLD 300
  301 AKPIKDLLLE YKAEVVEEVV DDETEEPRNS ALQLDLDDDS ASLQSQDIDK LPGTPTSILR 360
  361 DAKEQSQPSS SLPIAAAATA AAAATTTTKA TTPDRPNHTK DDNAEAAAQQ PPHTKVPAPA 420
  421 PPSSQQTPPP QVQQPPTPPA QPTAAVLQKK PEDVAAVAET SEKTESDKKH FVKKGKAPPP 480
  481 PSPLGLANAK PAASDSQTSP KKLATPEPTS PVTTAIEVAI GQEAMEPKPQ PPSPTASSIV 540
  541 SVQSVASSSS SGSVSNAVLS SSTSLITINS DPPTPHHHQP LPPQPQHLIL PNSLESVSQI 600
  601 TVVTSTHPPV IIDNSVMPPQ NEVIIVSNDM NKSTHLHESS TDDDFPSLDD SLGDATTPPH 660
  661 KQSSMILAVN EPAGVVPAPP SQPQTSSTVH ARKLDESEVL IVSPSYADDD SAYNTASGSH 720
  721 SHDHSDHLMD TSHVSVVTVG DEGVKVKDSS NELVKRQPNG VGIVPEDVNI IVNRFKQEKR 780
  781 SPDSSLSENG SVRGRRGIEV LVGGSGGSDV DSIGTNTSQE SRHETDHNNK QQYPAAALMP 840
  841 PPPPSLTNNH NHETIDEEEE VVIRPKARVP AVVKSANAQG LTKEEIELRN LRKKTRKRTR 900
  901 KFEIDGVQMT TTTSRVIYGD DENGRIYDDH DFRKQELREL KLLQKQEKKQ QTELHLKEQQ 960
  961 AKEQQDRRFE QERSSLEKTY EADMDMLARQ HKQLVEKTEQ TQENELRSSS KRIRSEQEQE1020
 1021 LKIFRENLKQ EIRLLKQEVD LFPKDKRKDE FKQRRSAMEL DHEEKERAFL DSLKERHELL1080
 1081 LRRLSEKHRD HLATINRNFL QQKQNAMRTR EALLWELEEK QLHERHQLSK RHVKELCFMQ1140
 1141 RHQMIIRHEK ELDQVKRMLQ RKEEDMVKKQ TMEKRALPKR IRAERKARDL MFRESLRIST1200
 1201 NLDPEIERDR LKKFQEQEKK RYMQEERRFE VKHQKQLEEL RATRESAIKE LEQLQNEKRR1260
 1261 ALVEHEHSKL SEIDERLKGE LREWREQLVP RKQELNRQIK LAIDQHEKRF GLVTNREEFE1320
 1321 DQEVKLPAHL RNIYNERSSR ILPRNTFIDP QNMPRSRSSL LMMGGGGNRL SNFRGSAPDL1380
 1381 SRSVPNTPIM HKQQRSQMIG DQVLEEDEEQ MLSEQMKRAS VATLPAQNQL RLITQLPANE1440
 1441 LVKVVTSTPP LNSAEDVNSK PSMSTFRGST PPKTPDDLGL VTNRFSRLDT KAAAEASGVE1500
 1501 LRIHEGPVLT AHTQRLLHTT SFAIKRPSLA SRSSGRSSLS SAQSMYNINE LSTRFTSDAD1560
 1561 LIFDSGRKAA ALLDEVQPQL RSSVKPGHSR ANGSVVSADS AASSEDIYYD LYAAQYKLPR1620
 1621 QLQQRLQQEV SPLIYPQCAS QPFDTTQGPE TGARRLEETF AQQLDEMETL YGGALIVSMP1680
 1681 SDTLQRDHFT GSTRSSLSSY SEG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..339] PSI-BLAST 69.69897 No description for 2j51A was found.
    2 View Details [340..398] deduced N/A No confident structure predictions are available.
    3 View Details [399..614] deduced N/A No confident structure predictions are available.
    4 View Details [615..683] deduced N/A No confident structure predictions are available.
    5 View Details [684..757] deduced N/A No confident structure predictions are available.
    6 View Details [758..1179] PSI-BLAST 19.522879 Heavy meromyosin subfragment
    7 View Details [1180..1303] FFAS03 1.49 crystal structure of the cytotoxic bacterial protein colicin B at 2.5 A resolution
    8 View Details [1304..1582] PSI-BLAST 8.0 Tropomyosin
    9 View Details [1583..1703] PSI-BLAST 3.221849 Crystal Structure Analysis of ClpB

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  2.07350687583102 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.47162554695064 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.46046123990071 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.32254739984688 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.0383359654359 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.794058505655489 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.775404673285876 bayes_pls_golite062009
  • DNA binding
    		•  0.714163549867672 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.63080698970012 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.57867852584301 bayes_pls_golite062009
  • transcription factor activity
    		•  0.563262875317016 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • transcription activator activity
    		•  0.481994471237116 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • kinase binding
    		•  0.443916188551908 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.391384757497683 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.351206771811872 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.340617390162297 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.339969855367828 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • protein kinase binding
    		•  0.285611963740145 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.0795689006739899 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  0.01826424351081 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle