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Protein Overview: CG7747-PA

General Information:
Name(s) found: CG7747-PA / FBpp0086323 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG7747 (CG7747, FBgn0034109). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12179765..12181631. It has the cytological map location 53B1. Based on sequence similarity, it is predicted to have molecular function</span>: peptidyl-prolyl cis-trans isomerase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein folding. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 517 amino acids

    Gene Ontology:
    Cellular Component: catalytic step 2 spliceosome [IDA]
    Biological Process: protein folding [IEA]
    nuclear mRNA splicing, via spliceosome [IC]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKRQHQKDK MYLTYTEWSE LYGGKKVESL ENDHVKFKRL PFEHCCITMA PYEMPYCDLQ  60
   61 GNVFEYEAIL KFLKTFKVNP ITGQKMDSKS LVKLNFHRNA NDEYHCPALF KPFSKNSHIV 120
  121 AVATTGNVYC WEAIDQLNIK TKNWKDLVDD TPFQRKDIIT IQDPQKLEKY DISTFYHIKK 180
  181 NLRVLTEEEQ QERKNPASGR IKTMNLETKE TLEQLQQDYQ PAEEEASTSK RTADKFNAAH 240
  241 YSTGAVAASF TSTAMVPVSQ IEAAIIDDDL VKYERVKKKG YVRLNTNLGP LNLELFCDQT 300
  301 PRACDNFIKH CANGYYNNVM FHRSIRNFIV QGGDPTGSGS GGESIWGKKF EDEFKPNLTH 360
  361 TGRGVLSMAN SGPNTNGSQF FITYRSCKHL DGKHTIFGKL VGGLDTLQKM ENIEVDNKDR 420
  421 PIEDIIIESS QVFVNPFAEA AEQLAKEREE EAAGKEEIVK KEEQQKRMKE PLKVYREGVG 480
  481 KYLKLQTVAK KPEAPLTSAQ AAKKKKLANG FGDFSSW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 14.69897 Crystal structure of the CHIP U-box E3 ubiquitin ligase
    2 View Details [107..153] FFAS03 2.02 Crystal structure of the Prp19 U-box dimer
    3 View Details [154..276] deduced N/A No confident structure predictions are available.
    4 View Details [277..517] PSI-BLAST 53.30103 Crystal Structure of Recombinant Human Cyclophilin J

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.78506998502716 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.55686022186257 bayes_pls_golite062009
    		• 4.77196423114965 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.59153177011595 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.07217714843839 bayes_pls_golite062009
  • RNA binding
    		•  3.04658201081989 bayes_pls_golite062009
  • binding
    		•  2.58862749918018 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.62076236255768 bayes_pls_golite062009
  • protein binding
    		•  1.49775478023418 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  1.37401357060257 bayes_pls_golite062009
  • peptidase activity
    		•  1.26418257706548 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.22180889694654 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.09332582339395 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.0455933268847 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • DNA binding
    		•  1.00346149950987 bayes_pls_golite062009
  • ligase activity
    		•  0.63517530468004 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.573573811866385 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • transcription factor binding
    		•  0.39685947299825 bayes_pls_golite062009
  • hydrolase activity
    		•  0.39313698408945 bayes_pls_golite062009
  • transcription factor activity
    		•  0.382098789505496 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • SUMO polymer binding
    		•  0.0588467253656506 bayes_pls_golite062009
  • antigen binding
    		•  0.0191313108005651 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.39046951458785 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.16068345159314 bayes_pls_golite062009
    		• 4.72885746116757 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.24782814163304 bayes_pls_golite062009
  • RNA binding
    		•  3.00624142341404 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.79292110382407 bayes_pls_golite062009
  • binding
    		•  2.51064774590911 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.58888342715984 bayes_pls_golite062009
  • protein binding
    		•  1.38611309393826 bayes_pls_golite062009
  • peptidase activity
    		•  1.25068211953419 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.21287410633544 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.07404910011569 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  1.03473176569589 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.02238152139385 bayes_pls_golite062009
  • DNA binding
    		•  1.00709690792313 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.951861817643521 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.821040441472875 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.567550697522097 bayes_pls_golite062009
  • ligase activity
    		•  0.424146907469434 bayes_pls_golite062009
  • hydrolase activity
    		•  0.421529723274632 bayes_pls_golite062009
  • transcription factor activity
    		•  0.3885123241249 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.356312424125648 bayes_pls_golite062009
  • transcription factor binding
    		•  0.265920091724011 bayes_pls_golite062009
  • catalytic activity
    		•  0.168711389690753 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.0136579100966835 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.19800591333648 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.9120328189871 bayes_pls_golite062009
  • binding
    		•  1.46018233647024 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.29596840005227 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.38915122244271 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • hydrolase activity
    		•  0.363074952403273 bayes_pls_golite062009
  • protein binding
    		•  0.130251391659493 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle