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Protein Overview: Cyp6a8-PA

General Information:
Name(s) found: Cyp6a8-PA / FBpp0086585 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Cytochrome P450-6a8 is referred to in FlyBase by the symbol Dmel\Cyp6a8 (CG10248, FBgn0013772). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10774673..10776514. It has the cytological map location 51D1. There is experimental evidence that it has the molecular function</span>: fatty acid (omega-1)-hydroxylase activity. There is experimental evidence that it is involved in the biological process</span>: response to caffeine; insecticide metabolic process; lauric acid metabolic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 506 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: lauric acid metabolic process [IDA]
    insecticide metabolic process [IDA]
    oxidation reduction [IEA]
    response to caffeine [IDA]
    Molecular Function: fatty acid (omega-1)-hydroxylase activity [IDA]
    electron carrier activity [ISS][NAS]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALTYILFQV AVALLAILTY YIHRKLTYFK RRGIPFVAPH LIRGNMEELQ KTKNIHEIFQ  60
   61 DHYNKFRESK APFVGFFFFQ SPAAFVIDLE LAKQILIKDF SNFSNKGIFY NEKDDPISAH 120
  121 LFNLDGAQWR LLRNKLSSTF TSGKMKLMYP TVVSVANEFM TVMHEKVPKN SVLEIRDLVA 180
  181 RFTVDVIGTC AFGIQCNSLR DEKAEFLYFG KRSLVDKRHG TLLNGFMRSY PKLARKLGMV 240
  241 RTAPHIQEFY SRIVTETVAV REKEHIKRND FMDMLIELKN QKEMTLENGD VVRGLTMEEV 300
  301 LAQAFVFFIA GFETSSSTMG FALYELAKNP DIQDKVRAEV EEVIEQHDQN FTYECTKDLK 360
  361 YLNQVLDETL RLYTIVPNLD RMAAKRYVVP GHPNFVIEAG QSVIIPSSAI HHDPSIYPEP 420
  421 FEFRPERFSP EESAGRPSVA WLPFGDGPRN CIGLRFGQMQ ARIGLALLIR NFKFSTCSKT 480
  481 PNPLVYDPKS FVLGVKDGIY LKVETV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..506] PSI-BLAST 98.522879 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  2.80780658333504 bayes_pls_golite062009
  • oxygen binding
    		•  2.77495508953933 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  2.60901411823382 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.33937429425924 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.21042366294727 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • retinoid binding
    		•  1.91237853759594 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.78853880472253 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • retinoic acid binding
    		•  1.55035199545719 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  1.48500938886158 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  1.46109575978397 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • iron ion binding
    		•  0.529598228513719 bayes_pls_golite062009
  • cation binding
    		•  0.510556740388808 bayes_pls_golite062009
  • metal ion binding
    		•  0.510556740388808 bayes_pls_golite062009
  • ion binding
    		•  0.503326724714616 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.450436868179747 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  0.203772707673481 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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