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Protein Overview: babo-PB

General Information:
Name(s) found: babo-PB / FBpp0087739 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene baboon is referred to in FlyBase by the symbol Dmel\babo (CG8224, FBgn0011300). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4839846..4850301. It has the cytological map location 44F11-44F12. There is experimental evidence that it has the molecular function</span>: activin binding. There is experimental evidence that it is involved in the biological process</span>: activin receptor signaling pathway; axon guidance; neuron development; eye-antennal disc morphogenesis; regulation of mitotic cell cycle; neuroblast proliferation; imaginal disc-derived wing morphogenesis; mushroom body development. 36 alleles are reported. The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: adult segment; multi-cell-component structure; nervous system; organ system; peripheral nervous system; adult brain; spiracle; external compound sense organ; larval head segment; integumentary specialisation; adult mesothoracic segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 622 amino acids

    Gene Ontology:
    Cellular Component: activin receptor complex [IPI][ISS]
    plasma membrane [NAS]
    Biological Process: mushroom body development [IMP]
    signal transduction [ISS]
    transforming growth factor beta receptor signaling pathway [ISS]
    imaginal disc-derived wing morphogenesis [IMP]
    eye-antennal disc morphogenesis [IGI]
    axon guidance [IMP]
    response to UV [IDA]
    neuron development [IMP]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    positive regulation of multicellular organism growth [TAS]
    regulation of mitotic cell cycle [IMP]
    dendrite morphogenesis [NAS]
    activin receptor signaling pathway [IDA]
    neuroblast proliferation [IMP]
    Molecular Function: ATP binding [IEA]
    activin binding [IDA]
    G-protein coupled receptor kinase activity [ISS]
    activin receptor activity, type I [ISS]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [NAS]
    transforming growth factor beta receptor activity, type I [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSALRLIFL GALLGASVCA SPIEFVMDTS LNGSRSDPAT ATHPGKWPPT TKAPALRAPA  60
   61 GTAGHAYQSP SSSLAADNRS HDNNNASAVS MLLPQDGDAS GAVAPAVTPQ LPIYIAQPSA 120
  121 KKPENKIKCH CDTCKESNNI CETDGFCFTS VEKNSDGSII FSYRCLHKSQ IFPPGRSIWC 180
  181 NDGLHGGPTA RPVGRNGAHA CCKDRDFCNR FLWPKTKDQR SDRVEEGRQI SVQDYVPHRL 240
  241 TSWEFVAIIL GATLFICFTG TSTWYYCQRR KRMASGRTFA KEDSAYDPIL NGNTTIHDII 300
  301 EMTTSGSGSA GLPLLVQRSI ARQVQLCHVI GKGRFGEVWR GRWRGENVAV KIFSSREECS 360
  361 WFREAEIYQT VMLRHENILG FIAADNKDNG TWTQLWLVTD YHENGSLFDY LTTHPVDTNT 420
  421 MLNMSLSIAT GLAHLHMDIV GTRGKPAIAH RDLKSKNILV KSNLSCAIGD LGLAVRHVEK 480
  481 NDSVDIPSTH RVGTKRYMAP EVLDESMNDQ HFDSYKRADV YAFGLILWEI ARRCNMGMIY 540
  541 DEYQLPYYDV VQPDPSIEEM KKVVCIEKCR PNIPNRWHAS DVLHNMAKVM KECWYPNPVA 600
  601 RLTALRIKKT LASISVEDKV KN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] PSI-BLAST 4.39794 No description for 2ahnA was found.
    2 View Details [145..274] FFAS03 2.36 Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor
    3 View Details [275..622] PSI-BLAST 76.522879 Type I TGF-beta receptor R4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • activin receptor activity
    		•  9.43409082112081 bayes_pls_golite062009
  • activin binding
    		•  7.11944534332244 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  6.41728494915949 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  6.1393596497059 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  3.98234977560207 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  3.98234977560207 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  3.37600307408153 bayes_pls_golite062009
  • follistatin binding
    		•  3.25716461198789 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.97315540587667 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  2.57601476622612 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • insulin receptor activity
    		•  2.08642574110801 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  2.08248852174113 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • activin receptor activity, type II
    		•  1.93639573827674 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.90879495821405 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  1.46877913443522 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.39074764291742 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • amine binding
    		•  1.3051205627964 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • PTB domain binding
    		•  1.14009984975509 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.08904623349766 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • insulin binding
    		•  1.03564126441771 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  0.898525973711213 bayes_pls_golite062009
  • stem cell factor receptor activity
    		•  0.877914726874139 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.57617745233877 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type II
    		•  0.365530951355731 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.34434685718027 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.312169974523858 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.294256794094724 bayes_pls_golite062009
  • inhibin binding
    		•  0.29024207998068 bayes_pls_golite062009
  • inhibin beta-A binding
    		•  0.29024207998068 bayes_pls_golite062009
  • inhibin beta-B binding
    		•  0.29024207998068 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.229808864843639 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • epidermal growth factor receptor activity
    		•  0.160217511793891 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.0123645889643007 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.96656737540424E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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