Protein Overview: EcR-PB, EcR-PG

General Information:
Name(s) found:	EcR-PG / FBpp0291631 [FlyBase] EcR-PB / FBpp0085352 [FlyBase]
Description(s) found: Found 35 descriptions. SHOW ALL	The gene Ecdysone receptor is referred to in FlyBase by the symbol Dmel\EcR (CG1765, FBgn0000546). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:1977924..2056681. It has the cytological map location 42A9-42A12. There is experimental evidence that it has the molecular function</span>: ecdysteroid hormone receptor activity; protein binding; protein heterodimerization activity. There is experimental evidence for 35 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; reproductive process in a multicellular organism; regulation of biological process; neuron differentiation; regulation of metabolic process; muscle organ development; embryonic development via the syncytial blastoderm; central nervous system development; organ morphogenesis. 136 alleles are reported. The phenotypes of these alleles are annotated with 55 unique terms, many of which group under: organ system; adult segment; imaginal precursor; cuticle; cephalopharyngeal skeleton; external compound sense organ; female germline cyst; nervous system; peripheral nervous system; adult mesothoracic segment. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase] The gene Ecdysone receptor is referred to in FlyBase by the symbol Dmel\EcR (CG1765, FBgn0000546). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:1977924..2056681. It has the cytological map location 42A9-42A12. There is experimental evidence that it has the molecular function</span>: ecdysteroid hormone receptor activity; protein binding; protein heterodimerization activity. There is experimental evidence for 35 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; reproductive process in a multicellular organism; regulation of biological process; neuron differentiation; regulation of metabolic process; muscle organ development; embryonic development via the syncytial blastoderm; central nervous system development; organ morphogenesis. 136 alleles are reported. The phenotypes of these alleles are annotated with 55 unique terms, many of which group under: organ system; adult segment; imaginal precursor; cuticle; cephalopharyngeal skeleton; external compound sense organ; female germline cyst; nervous system; peripheral nervous system; adult mesothoracic segment. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	878 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS] polytene chromosome [NAS] dendrite [IMP] cytoplasm [IDA] ecdysone receptor holocomplex [TAS]
Biological Process:	hatching [IMP] sperm individualization [IMP] germ-band shortening [IMP] regulation of development, heterochronic [TAS] determination of adult lifespan [IMP] chitin-based embryonic cuticle biosynthetic process [IMP] imaginal disc-derived wing morphogenesis [IGI][IMP] epidermis development [IMP] larval wandering behavior [IMP] cell adhesion [IMP] border follicle cell migration [IMP] metamorphosis [IMP] cardiac muscle tissue development [IMP] dendrite morphogenesis [IMP][NAS] negative regulation of transcription, DNA-dependent [TAS] ecdysis, chitin-based cuticle [IMP] autophagy [IMP] axonogenesis [IMP] pupariation [IMP] mushroom body development [IGI] spermatid development [IMP] imaginal disc eversion [TAS] dorsal vessel heart proper cell fate commitment [IMP] ecdysone receptor-mediated signaling pathway [IMP] head involution [IMP] response to cocaine [IGI] regulation of transcription, DNA-dependent [IEA] peripheral nervous system development [IMP] histoblast morphogenesis [IMP] larval central nervous system remodeling [IMP][TAS] ecdysone-mediated induction of salivary gland cell autophagic cell death [NAS] neuron development [IMP] regulation of transcription from RNA polymerase II promoter [IMP] regulation of rhodopsin gene expression [IMP] muscle organ development [IMP] oogenesis [IMP][NAS] positive regulation of apoptosis [IMP] neuron remodeling [IMP] cardioblast differentiation [IMP]
Molecular Function:	DNA binding [NAS] transcription factor activity [IEA] zinc ion binding [IEA] RNA polymerase I transcription factor activity [NAS] protein binding [IPI] ligand-dependent nuclear receptor activity [NAS][TAS] protein heterodimerization activity [IDA] sequence-specific DNA binding [IEA] steroid binding [IEA][NAS] ecdysteroid hormone receptor activity [IDA][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRRWSNNGG FMRLPEESSS EVTSSSNGLV LPSGVNMSPS SLDSHDYCDQ DLWLCGNESG  60
   61 SFGGSNGHGL SQQQQSVITL AMHGCSSTLP AQTTIIPING NANGNGGSTN GQYVPGATNL 120
  121 GALANGMLNG GFNGMQQQIQ NGHGLINSTT PSTPTTPLHL QQNLGGAGGG GIGGMGILHH 180
  181 ANGTPNGLIG VVGGGGGVGL GVGGGGVGGL GMQHTPRSDS VNSISSGRDD LSPSSSLNGY 240
  241 SANESCDAKK SKKGPAPRVQ EELCLVCGDR ASGYHYNALT CEGCKGFFRR SVTKSAVYCC 300
  301 KFGRACEMDM YMRRKCQECR LKKCLAVGMR PECVVPENQC AMKRREKKAQ KEKDKMTTSP 360
  361 SSQHGGNGSL ASGGGQDFVK KEILDLMTCE PPQHATIPLL PDEILAKCQA RNIPSLTYNQ 420
  421 LAVIYKLIWY QDGYEQPSEE DLRRIMSQPD ENESQTDVSF RHITEITILT VQLIVEFAKG 480
  481 LPAFTKIPQE DQITLLKACS SEVMMLRMAR RYDHSSDSIF FANNRSYTRD SYKMAGMADN 540
  541 IEDLLHFCRQ MFSMKVDNVE YALLTAIVIF SDRPGLEKAQ LVEAIQSYYI DTLRIYILNR 600
  601 HCGDSMSLVF YAKLLSILTE LRTLGNQNAE MCFSLKLKNR KLPKFLEEIW DVHAIPPSVQ 660
  661 SHLQITQEEN ERLERAERMR ASVGGAITAG IDCDSASTSA AAAAAQHQPQ PQPQPQPSSL 720
  721 TQNDSQHQTQ PQLQPQLPPQ LQGQLQPQLQ PQLQTQLQPQ IQPQPQLLPV SAPVPASVTA 780
  781 PGSLSAVSTS SEYMGGSAAI GPITPATTSS ITAAVTASST TSAVPMGNGV GVGVGVGGNV 840
  841 SMYANAQTAM ALMGVALHSH QEQLIGGVAV KSEHSTTA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..161]	PSI-BLAST	12.045757	RBP1
2	View Details	[162..255]	deduced	N/A	No confident structure predictions are available.
3	View Details	[256..328]	PSI-BLAST	31.221849	Crystal Structure of Heterodimeric Ecdsyone receptor DNA binding complex
4	View Details	[329..654]	PSI-BLAST	51.0	hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
5	View Details	[655..878]	FFAS03	1.03	No description for 2j63A was found.

Protein Overview: EcR-PB, EcR-PG

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: