Protein Overview: TRAF6_RAT

General Information:
Name(s) found:	TRAF6_RAT [Swiss-Prot]
Description(s) found: Found 14 descriptions. SHOW ALL	TNF receptor-associated factor 6 OS=Rattus norvegicus GN=Traf6 PE=2 SV=1 [Swiss-Prot]
Organism:	Rattus norvegicus
Length:	530 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IEA] nucleus [UNKNOWN][IEA] cytoplasm [UNKNOWN][IEA] cell cortex [IEA] cytosol [UNKNOWN] endosome membrane [UNKNOWN] plasma membrane [UNKNOWN]
Biological Process:	activation of NF-kappaB-inducing kinase activity [UNKNOWN][IEA] positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN][IEA] JNK cascade [IMP] odontogenesis of dentine-containing tooth [UNKNOWN][IEA] positive regulation of transcription from RNA polymerase II promoter [IMP] induction of apoptosis by extracellular signals [UNKNOWN] positive regulation of NF-kappaB transcription factor activity [UNKNOWN][IEA] negative regulation of transcription from RNA polymerase II promoter [UNKNOWN] positive regulation of smooth muscle cell proliferation [IMP] immune response [UNKNOWN][IEA] neural tube closure [IEA] anti-apoptosis [UNKNOWN] positive regulation of osteoclast differentiation [UNKNOWN] ossification [UNKNOWN][IEA] bone resorption [IEA] regulation of immunoglobulin secretion [UNKNOWN][IEA] cytokine-mediated signaling pathway [IMP] myeloid dendritic cell differentiation [UNKNOWN][IEA] apoptosis [UNKNOWN] activation of protein kinase activity [UNKNOWN] antigen processing and presentation of exogenous peptide antigen via MHC class II [UNKNOWN][IEA] T cell receptor signaling pathway [UNKNOWN][IEA] positive regulation of interleukin-2 production [UNKNOWN][IEA] protein autoubiquitination [UNKNOWN] signal transduction [UNKNOWN][IEA] protein polyubiquitination [UNKNOWN][IEA] membrane protein intracellular domain proteolysis [UNKNOWN] T-helper 1 type immune response [UNKNOWN][IEA] regulation of apoptosis [IEA] positive regulation of interleukin-6 biosynthetic process [UNKNOWN][IEA] positive regulation of T cell proliferation [IEA] cell development [UNKNOWN][IEA] I-kappaB kinase/NF-kappaB cascade [UNKNOWN] organ morphogenesis [UNKNOWN][IEA] osteoclast differentiation [IEA] positive regulation of interleukin-12 biosynthetic process [UNKNOWN][IEA] positive regulation of T cell cytokine production [UNKNOWN][IEA] response to interleukin-1 [UNKNOWN] protein K63-linked ubiquitination [UNKNOWN] interleukin-1-mediated signaling pathway [IEA] positive regulation of lipopolysaccharide-mediated signaling pathway [IEA]
Molecular Function:	ubiquitin-protein ligase activity [UNKNOWN][IEA] protein kinase binding [UNKNOWN] zinc ion binding [IEA] protein binding [UNKNOWN][IEA] histone deacetylase binding [UNKNOWN] metal ion binding [IEA] protein N-terminus binding [UNKNOWN] protein kinase B binding [UNKNOWN] transcription repressor activity [UNKNOWN] mitogen-activated protein kinase kinase kinase binding [UNKNOWN] ligase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLLNCENSC ASSQSSSDCC AAMANSCSAA MKDDSVSGCV STGNLSSSFM EEIQGYDVEF  60
   61 DPPLESKYEC PICLMALREA VQTPCGHRFC KACITKSIRD AGHKCPVDNE ILLENQLFPD 120
  121 NFAKREILSL TVKCPNKGCV QKMELRHLED HQVHCEFALV ICPQCQRFFQ KCQINKHIIE 180
  181 DCPRRQVSCV NCAVPMPYEE KEIHDQSCPL ANIICEYCGT ILIREQMPNH YDLDCPTAPV 240
  241 PCTFSVFGCH EKMQRNHLAR HLQENTQLHM RLLAQAVHNV NLSLRPCDAS SPSRGCRPED 300
  301 PNYEETVKQL EGRLVRQDHQ IRELTAKMET QSMHVSELKR TIRSLEDKVA EMEAQQCNGI 360
  361 YIWKIGNFGM HLKSQEEERP VVIHSPGFYT GRPGYKLCMR LHLQLPTAQR CANYISLFVH 420
  421 TMQGEYDSHL PWPFQGTIRL TILDQSEAVI RQNHEEVMDA KPELLAFQRP TIPRNPKGFG 480
  481 YVTFMHLEAL RQGTFIKDDT LLVRCEVSTR FDMGGLRKEG FQPRSTDAGV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.72

Protein Overview: TRAF6_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: