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The formation of bone involved in the continuous turnover of bone matrix and mineral. The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state. The deposition of calcium phosphate in bone tissue. Any process that activates or increases the frequency, rate or extent of bone formation. The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone. A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). The formation of bone by the replacement of cartilage tissue with mineralized bone. Any process that stops, prevents or reduces the frequency, rate or extent of bone formation. The formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified. Intramembranous ossification is the way flat bones and the shell of a turtle are formed. Any process that modulates the frequency, rate or extent of bone formation. The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: ossification
Acc: GO:0001503
Aspect: Biological Process
Desc: The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
Synonyms:
  • bone biosynthesis
  • bone formation
  • osteogenesis
Proteins in PDR annotated with:
   This term: 118 [Search]
   Term or descendants: 353 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001503 - ossification (interactive image map)
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