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The process whereby a signal is conveyed via the transfer of one or more phosphate groups. The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus. The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. The process of introducing a phosphate group into an I-kappaB protein. The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase. Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade. Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound. Any process that stops, prevents or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: I-kappaB kinase/NF-kappaB cascade
Acc: GO:0007249
Aspect: Biological Process
Desc: A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase.
Synonyms:
  • activation of the inhibitor of kappa kinase
  • NIK-I-kappaB/NF-kappaB cascade
Proteins in PDR annotated with:
   This term: 57 [Search]
   Term or descendants: 232 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007249 - I-kappaB kinase/NF-kappaB cascade (interactive image map)
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