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Protein Overview: EPHA7

General Information:
Name(s) found: EPHA7 [HGNC (HUGO)]
Description(s) found:
Found 40 descriptions.
SHOW ALL
  • EPH receptor A7 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 998 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFQTRYPSW IILCYIWLLR FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPNGWEEISG  60
   61 LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 120
  121 ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 180
  181 GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIFPDTVT GSEFSSLVEV RGTCVSSAEE 240
  241 EAENAPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RGFYKSSSQD LQCSRCPTHS 300
  301 FSDKEGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 360
  361 NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV TVMDLLAHAN YTFEVEAVNG 420
  421 VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 480
  481 YEKDQRERTY STVKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEATG 540
  541 KMFEATAVSS EQNPVIIIAV VAVAGTIILV FMVFGFIIGR RHCGYSKADQ EGDEELYFHF 600
  601 KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG AGEFGEVCSG RLKLPGKRDV 660
  661 AVAIKTLKVG YTEKQRRDFL CEASIMGQFD HPNVVHLEGV VTRGKPVMIV IEFMENGALD 720
  721 AFLRKHDGQF TVIQLVGMLR GIAAGMRYLA DMGYVHRDLA ARNILVNSNL VCKVSDFGLS 780
  781 RVIEDDPEAV YTTTGGKIPV RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM 840
  841 SNQDVIKAIE EGYRLPAPMD CPAGLHQLML DCWQKERAER PKFEQIVGIL DKMIRNPNSL 900
  901 KTPLGTCSRP ISPLLDQNTP DFTTFCSVGE WLQAIKMERY KDNFTAAGYN SLESVARMTI 960
  961 EDVMSLGITL VGHQKKIMSS IQTMRAQMLH LHGTGIQV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 92.522879 Ligand-binding domain of the ephb2 receptor tyrosine kinase
    2 View Details [216..464] PSI-BLAST 27.522879 Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
    3 View Details [465..580] PSI-BLAST 6.69897 Solution structure of the second fn3 domain of Eph receptor A8 protein
    4 View Details [581..669] FFAS03 2.08 Type I TGF-beta receptor R4
    5 View Details [670..908] PSI-BLAST 75.39794 Hemapoetic cell kinase Hck; Hemopoetic cell kinase Hck; Haemopoetic cell kinase Hck
    6 View Details [909..998] PSI-BLAST 87.69897 No description for 2qoqA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • integrin binding
    		•  3.61193098087012 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.80879825615822 bayes_pls_golite062009
  • receptor activity
    		•  2.77268648576901 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.47762337031838 bayes_pls_golite062009
  • binding
    		•  2.31774167130542 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.23073603832866 bayes_pls_golite062009
  • phosphatidylserine binding
    		•  2.22270974208755 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.03595043486636 bayes_pls_golite062009
  • signal transducer activity
    		•  2.03595043486636 bayes_pls_golite062009
  • protein binding
    		•  1.90867517664953 bayes_pls_golite062009
  • fucose binding
    		•  1.72607684089801 bayes_pls_golite062009
  • protein kinase activity
    		•  1.70755634087208 bayes_pls_golite062009
  • monosaccharide binding
    		•  1.62596107035359 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.39122779055629 bayes_pls_golite062009
  • kinase activity
    		•  1.31546222648513 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.28997154411534 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.26743933952271 bayes_pls_golite062009
  • vascular endothelial growth factor receptor activity
    		•  1.21634643105777 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.18833031215069 bayes_pls_golite062009
  • sugar binding
    		•  1.1562287794497 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.68697655195721 bayes_pls_golite062009
  • protein complex binding
    		•  0.56054373949313 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.533285414042183 bayes_pls_golite062009
  • transferase activity
    		•  0.530643564656921 bayes_pls_golite062009
  • receptor binding
    		•  0.365344483970243 bayes_pls_golite062009
  • DNA binding
    		•  0.324772578014229 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.24891369301653 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.16022291279782 bayes_pls_golite062009
  • phosphatidylethanolamine binding
    		•  0.121022714964449 bayes_pls_golite062009
    2
    Term Confidence Notes
  • receptor activity
    		•  4.00123250685257 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.81769911097805 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  3.46693868912799 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • signal transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • peptide antigen binding
    		•  2.94721224577771 bayes_pls_golite062009
  • IgG binding
    		•  2.46934133838327 bayes_pls_golite062009
  • integrin binding
    		•  2.42680883711596 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.36139848096635 bayes_pls_golite062009
  • growth factor binding
    		•  2.28613301180608 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • immunoglobulin receptor activity
    		•  1.82245235447822 bayes_pls_golite062009
  • antigen binding
    		•  1.63189745559168 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.52958974617075 bayes_pls_golite062009
  • actin filament binding
    		•  1.47359288623575 bayes_pls_golite062009
  • olfactory receptor activity
    		•  1.41283591505444 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36635494500222 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.30657787244536 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.27793818082552 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.24730237107473 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.02428106476324 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.02286631988334 bayes_pls_golite062009
  • kinase activity
    		•  0.929878054374821 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.878595022643164 bayes_pls_golite062009
  • protein complex binding
    		•  0.83543827718565 bayes_pls_golite062009
  • peptide binding
    		•  0.729048089532569 bayes_pls_golite062009
  • immunoglobulin binding
    		•  0.64138121404685 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • cytokine binding
    		•  0.631436442105379 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.564762108830441 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.518011841154552 bayes_pls_golite062009
  • cell surface binding
    		•  0.477483205369537 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.38670960441694 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.318890055375093 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.316848380982695 bayes_pls_golite062009
  • DNA binding
    		•  0.304320681250924 bayes_pls_golite062009
  • actin binding
    		•  0.18356099709255 bayes_pls_golite062009
  • transferase activity
    		•  0.053007146193305 bayes_pls_golite062009
    3
    Term Confidence Notes
  • cytokine receptor activity
    		•  6.1064338595335 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  3.63249501085562 bayes_pls_golite062009
  • interleukin-6 binding
    		•  3.43159399159985 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  3.43159399159985 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  2.34894404420874 bayes_pls_golite062009
  • interleukin-11 binding
    		•  2.34894404420874 bayes_pls_golite062009
  • prolactin receptor activity
    		•  2.15346920063421 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  2.12450488436659 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.08068947938928 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • integrin binding
    		•  1.91458191628393 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  1.74022530568614 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  1.74022530568614 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.69642470905172 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.6158868405814 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  1.49133343034886 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.47680672146246 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • heparin binding
    		•  1.40418056272895 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.15899955607967 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12142142875217 bayes_pls_golite062009
  • kinase activity
    		•  1.11027658115625 bayes_pls_golite062009
  • cell surface binding
    		•  1.05599555585797 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.0023527963889 bayes_pls_golite062009
  • peptide binding
    		•  0.92031154055894 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.894667058714949 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • actin filament binding
    		•  0.848221254225135 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.657804692814791 bayes_pls_golite062009
  • ankyrin binding
    		•  0.56921114104552 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • transcription activator activity
    		•  0.529736394173061 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.522840770355105 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.470959482317512 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • ciliary neurotrophic factor binding
    		•  0.390643601263371 bayes_pls_golite062009
  • DNA binding
    		•  0.310798383307903 bayes_pls_golite062009
  • interleukin-7 binding
    		•  0.301052531308189 bayes_pls_golite062009
  • transcription factor binding
    		•  0.210682741845199 bayes_pls_golite062009
  • pattern binding
    		•  0.16768253393396 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle