YRC Public Data Repository - Protein Structure Prediction

Protein:	EPHA7
Organism:	Homo sapiens
Length:	998 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EPHA7.

Description	E-value	Query Range	Subject Range
EPHA7 - EPH receptor A7	0.0	[1..998]	[1..998]
EPHA7_MOUSE - Ephrin type-A receptor 7 OS=Mus musculus GN=Epha7 PE=1 SV=2	0.0	[1..998]	[1..998]
gi\|73973485 - gi\|73973485\|ref\|XP_853923.1\| PREDICTED: similar to ephrin receptor EphA7 isoform 2 [Canis familiaris...	0.0	[1..998]	[1..998]
EPHA7_RAT - Ephrin type-A receptor 7 OS=Rattus norvegicus GN=Epha7 PE=1 SV=1	0.0	[1..998]	[1..998]
EPHA7_CHICK - Ephrin type-A receptor 7 OS=Gallus gallus GN=EPHA7 PE=2 SV=1	0.0	[1..998]	[1..993]

Back

Predicted Domain #1

Region A:
Residues: [1-215]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFQTRYPSW IILCYIWLLR FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPNGWEEISG  60
   61 LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 120
  121 ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 180
  181 GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.522879
Match:	1nukA
Description:	Ligand-binding domain of the ephb2 receptor tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
integrin binding	3.61193098087012	bayes_pls_golite062009
transmembrane receptor activity	2.80879825615822	bayes_pls_golite062009
receptor activity	2.77268648576901	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.47762337031838	bayes_pls_golite062009
binding	2.31774167130542	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.23073603832866	bayes_pls_golite062009
phosphatidylserine binding	2.22270974208755	bayes_pls_golite062009
molecular transducer activity	2.03595043486636	bayes_pls_golite062009
signal transducer activity	2.03595043486636	bayes_pls_golite062009
protein binding	1.90867517664953	bayes_pls_golite062009
fucose binding	1.72607684089801	bayes_pls_golite062009
protein kinase activity	1.70755634087208	bayes_pls_golite062009
monosaccharide binding	1.62596107035359	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.39122779055629	bayes_pls_golite062009
kinase activity	1.31546222648513	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.28997154411534	bayes_pls_golite062009
carbohydrate binding	1.26743933952271	bayes_pls_golite062009
vascular endothelial growth factor receptor activity	1.21634643105777	bayes_pls_golite062009
protein tyrosine kinase activity	1.18833031215069	bayes_pls_golite062009
sugar binding	1.1562287794497	bayes_pls_golite062009
glycoprotein binding	0.68697655195721	bayes_pls_golite062009
protein complex binding	0.56054373949313	bayes_pls_golite062009
nucleic acid binding	0.533285414042183	bayes_pls_golite062009
transferase activity	0.530643564656921	bayes_pls_golite062009
receptor binding	0.365344483970243	bayes_pls_golite062009
DNA binding	0.324772578014229	bayes_pls_golite062009
small conjugating protein ligase activity	0.24891369301653	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.16022291279782	bayes_pls_golite062009
phosphatidylethanolamine binding	0.121022714964449	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [216-464]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDTVTGSEFS SLVEVRGTCV SSAEEEAENA PRMHCSAEGE WLVPIGKCIC KAGYQQKGDT  60
   61 CEPCGRGFYK SSSQDLQCSR CPTHSFSDKE GSSRCECEDG YYRAPSDPPY VACTRPPSAP 120
  121 QNLIFNINQT TVSLEWSPPA DNGGRNDVTY RILCKRCSWE QGECVPCGSN IGYMPQQTGL 180
  181 EDNYVTVMDL LAHANYTFEV EAVNGVSDLS RSQRLFAAVS ITTGQAAPSQ VSGVMKERVL 240
  241 QRSVELSWQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.522879
Match:	1ry7B
Description:	Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor activity	4.00123250685257	bayes_pls_golite062009
transmembrane receptor activity	3.81769911097805	bayes_pls_golite062009
fibroblast growth factor 1 binding	3.46693868912799	bayes_pls_golite062009
binding	3.17641566810715	bayes_pls_golite062009
molecular transducer activity	3.10913345555941	bayes_pls_golite062009
signal transducer activity	3.10913345555941	bayes_pls_golite062009
peptide antigen binding	2.94721224577771	bayes_pls_golite062009
IgG binding	2.46934133838327	bayes_pls_golite062009
integrin binding	2.42680883711596	bayes_pls_golite062009
cytokine receptor activity	2.36139848096635	bayes_pls_golite062009
growth factor binding	2.28613301180608	bayes_pls_golite062009
protein binding	2.22855404705168	bayes_pls_golite062009
immunoglobulin receptor activity	1.82245235447822	bayes_pls_golite062009
antigen binding	1.63189745559168	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	1.52958974617075	bayes_pls_golite062009
actin filament binding	1.47359288623575	bayes_pls_golite062009
olfactory receptor activity	1.41283591505444	bayes_pls_golite062009
protein kinase activity	1.36635494500222	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.30657787244536	bayes_pls_golite062009
fibroblast growth factor binding	1.27793818082552	bayes_pls_golite062009
fibroblast growth factor receptor activity	1.24730237107473	bayes_pls_golite062009
G-protein coupled receptor activity	1.02428106476324	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.02286631988334	bayes_pls_golite062009
kinase activity	0.929878054374821	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.878595022643164	bayes_pls_golite062009
protein complex binding	0.83543827718565	bayes_pls_golite062009
peptide binding	0.729048089532569	bayes_pls_golite062009
immunoglobulin binding	0.64138121404685	bayes_pls_golite062009
receptor binding	0.632627479346393	bayes_pls_golite062009
cytokine binding	0.631436442105379	bayes_pls_golite062009
protein serine/threonine kinase activity	0.564762108830441	bayes_pls_golite062009
nucleic acid binding	0.518011841154552	bayes_pls_golite062009
cell surface binding	0.477483205369537	bayes_pls_golite062009
cytoskeletal protein binding	0.38670960441694	bayes_pls_golite062009
protein tyrosine kinase activity	0.318890055375093	bayes_pls_golite062009
transcription regulator activity	0.316848380982695	bayes_pls_golite062009
DNA binding	0.304320681250924	bayes_pls_golite062009
actin binding	0.18356099709255	bayes_pls_golite062009
transferase activity	0.053007146193305	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [465-580]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPEHPNGVIT EYEIKYYEKD QRERTYSTVK TKSTSASINN LKPGTVYVFQ IRAFTAAGYG  60
   61 NYSPRLDVAT LEEATGKMFE ATAVSSEQNP VIIIAVVAVA GTIILVFMVF GFIIGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	1x5lA
Description:	Solution structure of the second fn3 domain of Eph receptor A8 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytokine receptor activity	6.1064338595335	bayes_pls_golite062009
transmembrane receptor activity	4.81256300373074	bayes_pls_golite062009
receptor activity	4.66147271961356	bayes_pls_golite062009
cytokine binding	4.43581512268554	bayes_pls_golite062009
growth factor binding	4.06808996928726	bayes_pls_golite062009
molecular transducer activity	3.69234048247377	bayes_pls_golite062009
signal transducer activity	3.69234048247377	bayes_pls_golite062009
ciliary neurotrophic factor receptor activity	3.63249501085562	bayes_pls_golite062009
interleukin-6 binding	3.43159399159985	bayes_pls_golite062009
interleukin-6 receptor activity	3.43159399159985	bayes_pls_golite062009
protein binding	3.24522318184038	bayes_pls_golite062009
binding	3.12471204223368	bayes_pls_golite062009
interleukin-11 receptor activity	2.34894404420874	bayes_pls_golite062009
interleukin-11 binding	2.34894404420874	bayes_pls_golite062009
prolactin receptor activity	2.15346920063421	bayes_pls_golite062009
growth hormone receptor activity	2.12450488436659	bayes_pls_golite062009
peptide hormone binding	2.12033076929638	bayes_pls_golite062009
SH2 domain binding	2.08068947938928	bayes_pls_golite062009
axon guidance receptor activity	2.01367445237355	bayes_pls_golite062009
integrin binding	1.91458191628393	bayes_pls_golite062009
oncostatin-M receptor activity	1.74022530568614	bayes_pls_golite062009
leukemia inhibitory factor receptor activity	1.74022530568614	bayes_pls_golite062009
polysaccharide binding	1.69642470905172	bayes_pls_golite062009
interleukin-2 binding	1.67132604890013	bayes_pls_golite062009
glycosaminoglycan binding	1.6158868405814	bayes_pls_golite062009
ciliary neurotrophic factor receptor binding	1.49133343034886	bayes_pls_golite062009
cytokine receptor binding	1.47680672146246	bayes_pls_golite062009
protein kinase activity	1.42856560840953	bayes_pls_golite062009
heparin binding	1.40418056272895	bayes_pls_golite062009
receptor binding	1.31676259534833	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.15899955607967	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.12142142875217	bayes_pls_golite062009
kinase activity	1.11027658115625	bayes_pls_golite062009
cell surface binding	1.05599555585797	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.0023527963889	bayes_pls_golite062009
peptide binding	0.92031154055894	bayes_pls_golite062009
interleukin-2 receptor activity	0.894667058714949	bayes_pls_golite062009
protein dimerization activity	0.86564366658585	bayes_pls_golite062009
actin filament binding	0.848221254225135	bayes_pls_golite062009
protein serine/threonine kinase activity	0.703490254739121	bayes_pls_golite062009
cytoskeletal protein binding	0.657804692814791	bayes_pls_golite062009
ankyrin binding	0.56921114104552	bayes_pls_golite062009
identical protein binding	0.564711394496051	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	0.554350228628563	bayes_pls_golite062009
transcription activator activity	0.529736394173061	bayes_pls_golite062009
nucleic acid binding	0.522840770355105	bayes_pls_golite062009
hormone binding	0.49524185948356	bayes_pls_golite062009
transcription regulator activity	0.470959482317512	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.46168925186147	bayes_pls_golite062009
transferase activity	0.432850266451294	bayes_pls_golite062009
ciliary neurotrophic factor binding	0.390643601263371	bayes_pls_golite062009
DNA binding	0.310798383307903	bayes_pls_golite062009
interleukin-7 binding	0.301052531308189	bayes_pls_golite062009
transcription factor binding	0.210682741845199	bayes_pls_golite062009
pattern binding	0.16768253393396	bayes_pls_golite062009
protein heterodimerization activity	0.1430595594485	bayes_pls_golite062009
protein homodimerization activity	0.116391819218123	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [581-669]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RHCGYSKADQ EGDEELYFHF KFPGTKTYID PETYEDPNRA VHQFAKELDA SCIKIERVIG  60
   61 AGEFGEVCSG RLKLPGKRDV AVAIKTLKV

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.08
Match:	1b6cB
Description:	Type I TGF-beta receptor R4
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [670-908]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYTEKQRRDF LCEASIMGQF DHPNVVHLEG VVTRGKPVMI VIEFMENGAL DAFLRKHDGQ  60
   61 FTVIQLVGML RGIAAGMRYL ADMGYVHRDL AARNILVNSN LVCKVSDFGL SRVIEDDPEA 120
  121 VYTTTGGKIP VRWTAPEAIQ YRKFTSASDV WSYGIVMWEV MSYGERPYWD MSNQDVIKAI 180
  181 EEGYRLPAPM DCPAGLHQLM LDCWQKERAE RPKFEQIVGI LDKMIRNPNS LKTPLGTCS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	75.39794
Match:	1qcfA
Description:	Hemapoetic cell kinase Hck; Hemopoetic cell kinase Hck; Haemopoetic cell kinase Hck
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [909-998]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPISPLLDQN TPDFTTFCSV GEWLQAIKME RYKDNFTAAG YNSLESVARM TIEDVMSLGI  60
   61 TLVGHQKKIM SSIQTMRAQM LHLHGTGIQV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.69897
Match:	2qoqA
Description:	No description for 2qoqA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: