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Protein Overview: SCJ1

General Information:
Name(s) found: SCJ1 / YMR214W [SGD]
Description(s) found:
Found 16 descriptions.
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  • One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 377 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [IDALink to PubMed article]
    Biological Process: endoplasmic reticulum unfolded protein response [IMPLink to PubMed article]
    protein folding [IMPLink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    Molecular Function: chaperone binding [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIPKLYIHLI LSLLLLPLIL AQDYYAILEI DKDATEKEIK SAYRQLSKKY HPDKNAGSEE  60
   61 AHQKFIEVGE AYDVLSDPEK KKIYDQFGAD AVKNGGGGGG PGGPGAGGFH DPFDIFERMF 120
  121 QGGHGGPGGG FGQRQRQRGP MIKVQEKLSL KQFYSGSSIE FTLNLNDECD ACHGSGSADG 180
  181 KLAQCPDCQG RGVIIQVLRM GIMTQQIQQM CGRCGGTGQI IKNECKTCHG KKVTKKNKFF 240
  241 HVDVPPGAPR NYMDTRVGEA EKGPDFDAGD LVIEFKEKDT ENMGYRRRGD NLYRTEVLSA 300
  301 AEALYGGWQR TIEFLDENKP VKLSRPAHVV VSNGEVEVVK GFGMPKGSKG YGDLYIDYVV 360
  361 VMPKTFKSGQ NMLKDEL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) EMP24 ERP1 ERP2 KAR2 PHB2 SCJ1 SSS1 YEL1
    View Details Gavin AC, et al. (2006) KAR2 SCJ1
    View Details Gavin AC, et al. (2002) COP1 GLO3 GPT2 ILV1 PGK1 RET2 RET3 SAM1 SCJ1 SEC21 SEC26 SEC27 SEC28 SEH1 TOS1
    View Details Qiu et al. (2008) LHS1 PDI1 SCJ1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SXM1 SCJ1 1 Unpublished Fields Lab Data
    View Screen RSR1 SCJ1 1 Unpublished Fields Lab Data
    View Screen YJU2 SCJ1 1 Unpublished Fields Lab Data
    View Screen PHO85 SCJ1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SCJ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] PSI-BLAST 26.221849 DnaJ chaperone, N-terminal (J) domain
    2 View Details [123..377] PSI-BLAST 47.39794 The crystal structure of Hsp40 Ydj1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  3.04403163860617 bayes_pls_golite062009
  • chaperone binding
    		•  2.86745334638583 bayes_pls_golite062009
  • binding
    		•  2.63138872417193 bayes_pls_golite062009
  • heat shock protein binding
    		•  2.17994194200939 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.91297632253219 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.6342534817623 bayes_pls_golite062009
  • protein binding
    		•  1.60937254813642 bayes_pls_golite062009
  • DNA binding
    		•  1.55234338199368 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  0.541755903922701 bayes_pls_golite062009
  • transferase activity
    		•  0.240656521918556 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0276971914937192 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.7298921704023 bayes_pls_golite062009
  • protein disulfide isomerase activity
    		•  2.4409950647303 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  2.4409950647303 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  2.23398279564144 bayes_pls_golite062009
  • unfolded protein binding
    		•  2.04158808514315 bayes_pls_golite062009
  • protein binding
    		•  1.57926302986794 bayes_pls_golite062009
  • receptor binding
    		•  0.507762060964961 bayes_pls_golite062009
  • catalytic activity
    		•  0.276917867171685 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle