Protein Overview: YTH1

General Information:
Name(s) found:	YTH1 / YPR107C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|914978\|gb\|AAB68077.1\| Ypr107cp [Saccharomyces cerevisiae] [NCBI NR] gi\|74676379\|sp\|Q06102.1\|YTH1_YEAST RecName: Full=mRNA 3'-end-processing protein YTH1; AltName: Full=Yeast 30 kDa homolog 1 [NCBI NR] gi\|6325364\|ref\|NP_015432.1\| Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; Yth1p [Saccharomyces cerevisiae] [NCBI NR] gi\|45270012\|gb\|AAS56387.1\| YPR107C [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S59772 hypothetical protein YPR107c - yeast (Saccharomyces cerevisiae) [NCBI NR] mRNA 3'-end-processing protein YTH1 OS=Saccharomyces cerevisiae GN=YTH1 PE=1 SV=1 [Swiss-Prot] YTH1 Protein of the 3` processing complex [mips] Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation [SGD] >Q06102 (Q06102) Chromosome XVI COSMID 8283 [4932.FASTACCERV.txt] Chr XVI from 742060-741434, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XVI from 741435-742061, reverse complement [yeastorf3.fasta] YTH1, Chr XVI from 741435-742061, reverse complement [yeast_orfs2] YTH1 SGDID:S0006311, Chr XVI from 742060-741434, reverse complement, Verified ORF [yeastflysequest.fasta] YTH1 SGDID:S0006311, Chr XVI from 742062-741436, reverse complement, Verified ORF [10112005cervSGD.fasta] Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation [Saccharomyces cerevisiae]gi\|914978\|gb\|AAB68077.1\| Ypr107cp [Saccharomyces cerevisiae]gi\|2132 [nrdb_11152004_Chlamydomonas] (Q06102) Ypr107cp (YPR107C) [cerv4932.FASTAC] YTH1 SGDID:S000006311, Chr XVI from 742062-741436, reverse complement, Verified ORF, "Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; Yth1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ypr107cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] mRNA 3'-end-processing protein YTH1 (Yeast 30 kDa homolog 1) [nr-271106-contam.fasta] YPR107C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] mRNA 3'-end-processing protein YTH1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YTH1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YTH1 SGDID:S000006311, Chr XVI from 742064-741438, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation" [yeast-030211-contam.fasta] YTH1 SGDID:S000006311, Chr XVI from 742064-741438, Genome Release 64-2-1, reverse complement, Verified ORF, "Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia" [20141208_orf_trans.fasta] TR4831\|c0_g1_i1\|g.3382 ORF TR4831\|c0_g1_i1\|g.3382 TR4831\|c0_g1_i1\|m.3382 type:complete len:209 (+) TR4831\|c0_g1_i1:86-712(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR3150\|c0_g1_i1\|g.2127 ORF TR3150\|c0_g1_i1\|g.2127 TR3150\|c0_g1_i1\|m.2127 type:complete len:209 (+) TR3150\|c0_g1_i1:127-753(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YPR107C SGDID:S000006311, Chr XVI from 742064-741438, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_3290\|g.2660 ORF asmbl_3290\|g.2660 asmbl_3290\|m.2660 type:complete len:209 (+) asmbl_3290:117-743(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_3505\|g.2463 ORF asmbl_3505\|g.2463 asmbl_3505\|m.2463 type:complete len:209 (+) asmbl_3505:85-711(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_3690\|g.2236 ORF ID=asmbl_3690\|g.2236 ID=asmbl_3690\|m.2236 type:complete len:209 (+) ID=asmbl_3690:117-743(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_3506\|g.1930 ORF ID=asmbl_3506\|g.1930 ID=asmbl_3506\|m.1930 type:complete len:209 (+) ID=asmbl_3506:85-711(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	208 amino acids
Gene Ontology:
Cellular Component:	mRNA cleavage and polyadenylation specificity factor complex [IPI][TAS]
Biological Process:	mRNA polyadenylation [IDA][IMP][TAS] mRNA cleavage [IDA][IMP][TAS]
Molecular Function:	RNA binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLIHPDTAK YPFKFEPFLR QEYSFSLDPD RPICEFYNSR EGPKSCPRGP LCPKKHVLPI  60
   61 FQNKIVCRHW LRGLCKKNDQ CEYLHEYNLR KMPECVFFSK NGYCTQSPDC QYLHIDPASK 120
  121 IPKCENYEMG FCPLGSSCPR RHIKKVFCQR YMTGFCPLGK DECDMEHPQF IIPDEGSKLR 180
  181 IKRDDEINTR KMDEEKERRL NAIINGEV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CFT1 CFT2 FIP1 GLC7 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 YSH1 YTH1
View Details	Krogan NJ, et al. (2006)		AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1
View Details	Gavin AC, et al. (2006)		CFT1 CFT2 FIP1 MPE1 PAP1 PFS2 PTA1 YSH1 YTH1
View Details	Gavin AC, et al. (2002)		ACT1 AIM31 CFT1 CFT2 CKA1 CLP1 ENO2 FIP1 GLC7 HHF1, HHF2 HTA1 MPE1 PAP1 PCF11 PFK1 PFS2 PTA1 PTI1 REF2 RNA14 RNA15 RSA3 SEC13 SEC31 SSA3 SSU72 SYC1 TAF6 TIF4632 TYE7 VID24 VMR1 VPS53 YCL046W YSH1 YTH1
View Details	Qiu et al. (2008)		CFT1 CFT2 CLP1 HRP1 PFS2 PTI1 REF2 RNA14 RNA15 YTH1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ROM2	YTH1	2	Unpublished Fields Lab Data
View Screen	VPS5	YTH1	1	Unpublished Fields Lab Data
View Screen	SWI5	YTH1	1	Unpublished Fields Lab Data
View Screen	YJR141W	YTH1	1	Unpublished Fields Lab Data
View Screen	BUR2	YTH1	1	Unpublished Fields Lab Data
View Screen	SPT21	YTH1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YTH1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..120]	PSI-BLAST	6.0	Tristetraproline (ttp, tis11, nup475)
2	View Details	[121..208]	MSA	5.111994	View MSA. No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2