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Protein Overview: CET1

General Information:
Name(s) found: CET1 / YPL228W [SGD]
Description(s) found:
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  • gi|6325028|ref|NP_015096.1| Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide; [NCBI NR]
  • pir||S61706 RNA 5'-triphosphatase (EC 3.6.1.-) beta chain - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1370472|emb|CAA97944.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1181260|emb|CAA64259.1| P1433 [Saccharomyces cerevisiae] [NCBI NR]
  • CET1 RNA 5`-triphosphatase (mRNA capping enzyme, beta subunit) [mips]
  • Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide [SGD]
  • Chr XVI from 118382-120031 [hmr_yeast5_DM3-1_pombe.fasta]
  • CET1, Chr XVI from 118382-120031 [yeast_orfs2]
  • CET1 SGDID:S0006149, Chr XVI from 118382-120031, Verified ORF [yeastflysequest.fasta]
  • Cet1p [Saccharomyces cerevisiae]gi|1370472|emb|CAA97944.1| unnamed protein product [Saccharomyces cerevisiae]gi|1181260|emb|CAA64259.1| P1433 [Saccharomyces cerevisiae]gi|2132239|pir||S61706 RNA 5'-triphosphatase (EC 3.6.1.-) beta chain - yeast (Sacch [nrdb_11152004_Chlamydomonas]
  • CET1 SGDID:S000006149, Chr XVI from 118382-120031, Verified ORF, "Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • P1433 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide; Cet1p [Saccharomyces cerevi [nr-271106-contam.fasta]
  • CET1 SGDID:S000006149, Chr XVI from 118382-120031, Verified ORF, "Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • mRNA-capping enzyme subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CET1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CET1 SGDID:S000006149, Chr XVI from 118382-120031, Genome Release 64-1-1, Verified ORF, "Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide" [yeast-030211-contam.fasta]
  • CET1 SGDID:S000006149, Chr XVI from 118382-120031, Genome Release 64-2-1, Verified ORF, "RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of the mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of the guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNA pol II pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is a single bifunctional polypeptide; CET1 has a paralog, CTL1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YPL228W SGDID:S000006149, Chr XVI from 118382-120031, Genome Release 64-1-1, Verified ORF, "Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 549 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: mRNA capping [TASLink to PubMed article]
    Molecular Function: polynucleotide 5'-phosphatase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYTDNPPQT KRALSLDDLV NHDENEKVKL QKLSEAANGS RPFAENLESD INQTETGQAA  60
   61 PIDNYKESTG HGSHSQKPKS RKSSNDDEET DTDDEMGASG EINFDSEMDF DYDKQHRNLL 120
  121 SNGSPPMNDG SDANAKLEKP SDDSIHQNSK SDEEQRIPKQ GNEGNIASNY ITQVPLQKQK 180
  181 QTEKKIAGNA VGSVVKKEEE ANAAVDNIFE EKATLQSKKN NIKRDLEVLN EISASSKPSK 240
  241 YRNVPIWAQK WKPTIKALQS INVKDLKIDP SFLNIIPDDD LTKSVQDWVY ATIYSIAPEL 300
  301 RSFIELEMKF GVIIDAKGPD RVNPPVSSQC VFTELDAHLT PNIDASLFKE LSKYIRGISE 360
  361 VTENTGKFSI IESQTRDSVY RVGLSTQRPR FLRMSTDIKT GRVGQFIEKR HVAQLLLYSP 420
  421 KDSYDVKISL NLELPVPDND PPEKYKSQSP ISERTKDRVS YIHNDSCTRI DITKVENHNQ 480
  481 NSKSRQSETT HEVELEINTP ALLNAFDNIT NDSKEYASLI RTFLNNGTII RRKLSSLSYE 540
  541 IFEGSKKVM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CEG1 CET1
    View Details (MIPS) Mewes HW, et al. (2004) CEG1 CET1
    View Details Krogan NJ, et al. (2006) CEG1 CET1 YHR130C
    View Details Gavin AC, et al. (2006) CEG1 CET1
    View Details Gavin AC, et al. (2002) AVO1 BEM2 CEG1 CET1 CLU1 CTR9 HHF1, HHF2 LSM12 NIP1 NOP1 PDB1 PRP43 RPG1 SPT16 SSA3 SSA4 TOP2 VPS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CET1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] deduced N/A No confident structure predictions are available.
    2 View Details [220..549] PSI-BLAST 1834.0 mRNA triphosphatase CET1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • polynucleotide 5'-phosphatase activity
    		•  11.2864202061301 bayes_pls_golite062009
  • nucleotide phosphatase activity
    		•  5.10806075014632 bayes_pls_golite062009
  • binding
    		•  1.32114964285132 bayes_pls_golite062009
  • catalytic activity
    		•  1.17990683373825 bayes_pls_golite062009
  • hydrolase activity
    		•  0.487109994827608 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle