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Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage. Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nucleotide phosphatase activity
Acc: GO:0019204
Aspect: Molecular Function
Desc: Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate.
Synonyms:
  • polynucleotide phosphatase activity
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 21 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0019204 - nucleotide phosphatase activity (interactive image map)
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