Protein Overview: KAP120

General Information:
Name(s) found:	KAP120 / YPL125W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74676325\|sp\|Q02932.1\|KA120_YEAST RecName: Full=Importin beta-like protein KAP120; AltName: Full=Karyopherin-120 [NCBI NR] gi\|6325132\|ref\|NP_015200.1\| Karyopherin with a role in the assembly or export of 60S ribosomal subunits; Kap120p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S61997 hypothetical protein YPL125w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1163089\|gb\|AAB68237.1\| Ypl125wp [Saccharomyces cerevisiae] [NCBI NR] Importin beta-like protein KAP120 OS=Saccharomyces cerevisiae GN=KAP120 PE=1 SV=1 [Swiss-Prot] KAP120 Nuclear transport factor, member of karyopherin-beta family [mips] Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p [SGD] >Q02932 (Q02932) LPH2P [4932.FASTACCERV.txt] Chr XVI from 313387-316485 [hmr_yeast5_DM3-1_pombe.fasta] KAP120, Chr XVI from 313387-316485 [yeast_orfs2] KAP120 SGDID:S0006046, Chr XVI from 313387-316485, Verified ORF [yeastflysequest.fasta] Kap120p [Saccharomyces cerevisiae]gi\|2132197\|pir\|\|S61997 hypothetical protein YPL125w - yeast (Saccharomyces cerevisiae)gi\|1163089\|gb\|AAB68237.1\| Lph2p [nrdb_11152004_Chlamydomonas] (Q02932) Ypl125wp [cerv4932.FASTAC] KAP120 SGDID:S000006046, Chr XVI from 313387-316485, Verified ORF, "Karyopherin with a role in the assembly or export of 60S ribosomal subunits" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] KAP120 SGDID:S000006046, Chr XVI from 313387-316485, Verified ORF, "Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p" [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta] Ypl125wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Karyopherin with a role in the assembly or export of 60S ribosomal subunits; Kap120p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Importin beta-like protein KAP120 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KAP120 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] KAP120 SGDID:S000006046, Chr XVI from 313388-316486, Genome Release 64-1-1, Verified ORF, "Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p" [yeast-030211-contam.fasta] KAP120 SGDID:S000006046, Chr XVI from 313388-316486, Genome Release 64-2-1, Verified ORF, "Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor" [20141208_orf_trans.fasta] YPL125W SGDID:S000006046, Chr XVI from 313388-316486, Genome Release 64-1-1, Verified ORF, "Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	1032 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] nuclear pore [IDA]
Biological Process:	protein import into nucleus [IPI]
Molecular Function:	structural constituent of nuclear pore [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSLNELNL VQVLEQASNP QHIRSDVQKL AEQQLRQWET QAGFHYLLQS IYLNLSNSLQ  60
   61 IRWLAVIQFK NGVDKYWRST RINAIPKDEK ASIRGRLFEM IDEQNNQLCI QNAQASARIA 120
  121 RLDFPVEWPT LFEDLENLLN DEIIRKDSVK IYNILMHINQ IVKVLGTARI GRCRPAMQSK 180
  181 VPLILPLIVR IYLQSFEEWT TSSNLNYEDL SSLQVSYLAL KVLRRIICEG YDRPQTDQSV 240
  241 CDFIKLSVSH FEMLISNHEN FKKFDIYEKF IKCLGKLYFN LVTGSPANFI LLPCSTQILI 300
  301 TYTRLIFDKA PKVYRENSDV TGDFWEQTAI RGLLILKRVI NFIHKKGAIT LKARSDKLTI 360
  361 DASINKINTE FLNENLITRL VDTLMEWYLR LRPTELENWF MDPEEWINEQ MATSYEYQIR 420
  421 PCAENVFQDL MNTFSELLVP YLLKKIENDA SKLSNSLDDF LRKDAIYASF QLSASAVSEM 480
  481 VDFDRLLIQV FLPEATNTNI SGDELRIIRR RVALIINEWS TVKCSEESKS LCYKLFTNFL 540
  541 TDEDDKVVLL TTVQTVRTMV DDWNFNKDTF QPFLTENVHL LLRKILPSVS LTETRLYVLN 600
  601 TLSDIIIQTK PLISRDLLVE ILQIIPNLWE IATNNASEAI LANALLRLLR NLVSSLGSQS 660
  661 HLTWDIAIPV VALACDPSSM QYQLLSEDGY ELWGMLLQNF SSHDQEFDDK FVELVPFLKY 720
  721 GIETHTEILP TLLEIIKSYA LILNPVDFFS NNTFQDIFKQ MSKYLLKLRE DSFQLVLEIW 780
  781 EILILSNESD YENLLLQKFY ETGVLSALFD AIFLEEAPSS YLCSQIIQII ARISYVNPDA 840
  841 LMTFLATYHD NLPTSNENAR MPESIRKIVS KDQTYDSVVN KLLTGWIVCF RDIFDPKFKK 900
  901 VHILGISSLL RTGLVPILTE FSSIASLWIE MLEEINETNR GDCEKYHLND IVTEQSIAFH 960
  961 PLTAEQLRYH QLCKNNDPVH NISLKDFISQ SMEYLESHLG VERYQEFLKT INPSLLENLQ1020
 1021 MFLSIQPQEA RP

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		KAP120 KAP123 MEX67 NSP1 NUP116 NUP133 NUP159 NUP170 NUP188 NUP192 NUP2 NUP42 NUP82 NUP84 NUP85 POM152 SUS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	BOI1	Sample boi 1 with ha tag from october 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	KAP120	Huh WK, et al. (2003)

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
nucleic acid binding	2.34284977509828	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
nuclear export signal receptor activity	2.13470398426489	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
transcription regulator activity	1.76231475025891	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
DNA binding	1.62032607987786	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
transcription factor activity	0.923253759652909	bayes_pls_golite062009
structural molecule activity	0.908029258648777	bayes_pls_golite062009
translation initiation factor activity	0.83079633551839	bayes_pls_golite062009
translation regulator activity	0.82193201542158	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.803700928110921	bayes_pls_golite062009
molecular transducer activity	0.662662274021266	bayes_pls_golite062009
signal transducer activity	0.662662274021266	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
mRNA binding	0.46864854653143	bayes_pls_golite062009
RNA binding	0.40024158562931	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
transcription activator activity	0.0232727461674547	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..702]	MSA	15.219994	View MSA. No confident structure predictions are available.
2	View Details	[703..916]	MSA	2.17099	View MSA. No confident structure predictions are available.
3	View Details	[917..1032]	MSA	1.063977	View MSA. No confident structure predictions are available.

Protein Overview: KAP120

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: