Protein Overview: PMT3

General Information:
Name(s) found:	PMT3 / YOR321W [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals [SGD]
Organism:	Saccharomyces cerevisiae
Length:	753 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum [TAS]
Biological Process:	protein amino acid O-linked glycosylation [IMP][ISS]
Molecular Function:	dolichyl-phosphate-mannose-protein mannosyltransferase activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYRVATGYS EKSTDDDLIW RTPIVKEELE DADNFLKDDA ELYDKVKNES AVSHLDTIVM  60
   61 PIIFTVLGMF TRMYKIGRNN HVVWDEAHFG KFGSYYLRHE FYHDVHPPLG KMLVGLSGYL 120
  121 AGYNGSWDFP SGEVYPDYID YVKMRLFQAM FSSLCVPLAY FTGRAIGFSR LSVWLFTILV 180
  181 IFENSYATLG KFILLDSMLL FFTVSSYFCL AKFHTMRKSP FSARWWLWLC LTGLNLGCAI 240
  241 SVKMVGLFII SVVGIYTISE LWNLLSDRSV SWKVYVNHWL ARIFGLIIIP VCVFLLCFKI 300
  301 HFDLLSNSGP GDSTMPSLFQ ASLNGTKVGK GPRDVALGSS IISIKNQALG GALLHSHVQP 360
  361 FPEGSEQQQV TVYGYSDANN EWFFQRIRGV EPWTDAENKT IEFVKGGEMY RLMHRLTGKN 420
  421 LHTHEVPAPI SKSEYEVSAY GDVDLGDYKD NWIIEIVEQV GEEDPTLLHP LSTSFRIKNS 480
  481 ILGCYLAQSG KHLPEWGFRQ GEVVCLKHAS KRDKRTWWNI ETHENERLPQ GEDFVYPKTS 540
  541 FFRNFMQLNS AMMATNNALV PNPEKFDGIA SSAWQWPTLN VGVRLCEWSE KSIKYFLLGS 600
  601 PASVWPSSIA VCALIIHVIF LTLKWQRQCV ILSDPVERDV FVMAAFYPLL AWLLHYMPFV 660
  661 VMSRVVYAHH YLPTLYFALM ILSYYFDMIT KRWATRNTGK FLRLGAYIVY GSIVIAGFFY 720
  721 FSPFSFGMDG PVDDYAYLAW LPTWQIVEDI RNT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		ALG2 PMT1 PMT2 PMT3 PMT4 PMT5 PMT6 STT3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YIF1	PMT3	2	Unpublished Fields Lab Data
View Screen	PHS1	PMT3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PMT3	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..104]	MSA	1.46399	View MSA. No confident structure predictions are available.
2	View Details	[105..331]	MSA	8.482996	View MSA. No confident structure predictions are available.
3	View Details	[332..379]	Pfam	11.958607	No description for PF02815.7 was found. No confident structure predictions are available.
4	View Details	[380..459]	Pfam	14.49485	No description for PF02815.7 was found. No confident structure predictions are available.
5	View Details	[460..536]	Pfam	12.79588	No description for PF02815.7 was found. No confident structure predictions are available.
6	View Details	[537..753]	MSA	2.050977	View MSA. No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	pre 2.0c	PSIPRED	pre v2.61
SignalP	pre 3.0	COILS	1999
DISOPRED	pre v0.2	NCBI nr	circa 2005
PSI-BLAST	~2.2.10	FFAS	ffas
PDB	~2005	Pfam	16
HMMER	2.3.1