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Protein Overview: PMT5

General Information:
Name(s) found: PMT5 / YDL093W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 743 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [TASLink to PubMed article]
    Biological Process: protein amino acid O-linked glycosylation [TASLink to PubMed article]
    Molecular Function: dolichyl-phosphate-mannose-protein mannosyltransferase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKEHLLKVD PIPDVTIKRG PLRSFLITKP CDNLSSLRTV TSSKEKLLVG CLLIFTAIVR  60
   61 LHNISLPNSV VFGENEVGTF VSQYVNNIFF TDVHPPLVAM LYATVSSVFG YKGLFNYGNI 120
  121 GTEYTANVPY VAMRFFSATL GIVSVLVLYL TLRVSGVKIA VAAICAVCFA IENSFVTLSR 180
  181 FTLIEGPFVF FMACAVYFFR RSELYLPNSC KANKSLLAAS IALGFAVSSK WAGLFTIAWA 240
  241 GIIVLWRVWF MIGDLSRPIG SSIKYMAFQF TCLLAIPAFI YFLIFSVHIK TLNVNGISSS 300
  301 FFPAEFRKTL KYNNVIKETV AEVAVGSAVS LNHVGTAGGY LHSHLHNYPA GSMQQQVTLY 360
  361 PHIDQNNKWI IELAEHPNEN VTSFQNLTDG TIIKLRQLKN GCRLHSHDHK PPVSQNADWQ 420
  421 KEVSCYGYEG FEGDINDDWI IEIDKKRSEP GPAQEHIRAI ETKFRLKHYL TGCYLFSHPE 480
  481 KLPEWGFGQQ EVTCAYFARE DLTSWYIEEN ENEISLPNPE KVSYKKMSFW QKFVAIHKFM 540
  541 FYLNNYMDTS HAYSSEPKTW PLMLRGIDFW NENGREVYFL GNAVLWWSVT AFICTFIIGV 600
  601 AVELLAWKLG VNILRDKHII NFHYQVFQYL LGFAAHYFPY FFVGQKLFLY DYLPAYYFGI 660
  661 LAFGHALDLI STYISNKRNN TGYIVVAIFM VVCFYFFSEH SPLIYATGWS SNLCKRSKWL 720
  721 GSWDFYCNSL LLSDSHYELN AES

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CRC1 PMT5 RUB1 RUD3
    View Details Qiu et al. (2008) PMT3 PMT5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..317] Pfam 86.19382 Dolichyl-phosphate-mannose-protein mannosyltransferase No confident structure predictions are available.
    2 View Details [318..378] Pfam 16.387216 MIR domain No confident structure predictions are available.
    3 View Details [379..452] Pfam 15.886057 MIR domain No confident structure predictions are available.
    4 View Details [453..525] Pfam 16.958607 MIR domain No confident structure predictions are available.
    5 View Details [526..743] MSA 3.030966 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • dolichyl-phosphate-mannose-protein mannosyltransferase activity
    		•  7.33543412640964 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  6.32966341675541 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.60661923349025 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.57555885876017 bayes_pls_golite062009
  • receptor activity
    		•  1.99332745476324 bayes_pls_golite062009
  • binding
    		•  1.86366637427031 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.71523634580131 bayes_pls_golite062009
  • signal transducer activity
    		•  1.71523634580131 bayes_pls_golite062009
  • cation channel activity
    		•  1.66500687404195 bayes_pls_golite062009
  • ion channel activity
    		•  1.61859406934521 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.57127083095499 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.55374970486978 bayes_pls_golite062009
  • channel activity
    		•  1.55374970486978 bayes_pls_golite062009
  • inositol-1,4,5-trisphosphate receptor activity
    		•  1.28298370923705 bayes_pls_golite062009
  • transferase activity
    		•  0.981084601370981 bayes_pls_golite062009
  • calcium channel activity
    		•  0.85901349040585 bayes_pls_golite062009
  • catalytic activity
    		•  0.659936859803906 bayes_pls_golite062009
  • calcium-release channel activity
    		•  0.65133561512386 bayes_pls_golite062009
  • gated channel activity
    		•  0.53737429019655 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.52162184692236 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.52162184692236 bayes_pls_golite062009
  • protein binding
    		•  0.405144403982597 bayes_pls_golite062009
  • inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
    		•  0.152598505509111 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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