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Protein Overview: TGL5

General Information:
Name(s) found: TGL5 / YOR081C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Bifunction enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 749 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDALink to PubMed articleLink to PubMed article]
    Biological Process: triglyceride mobilization [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: triglyceride lipase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNTLPVTEF LLSKYYELSN TPATDSSSLF KWLYHKTLSR KQLLISDLSS QKKHAISYDQ  60
   61 WNDIASRLDD LTGLSEWKTI DESSLYNYKL LQDLTIRMRH LRTTHDYHRL LYLIRTKWVR 120
  121 NLGNMNNVNL YRHSHTGTKQ IIHDYLEESQ AVLTALIHQS NMNDHYLLGI LQQTRRNIGR 180
  181 TALVLSGGST FGLFHIGVLA ALFESDLMPK VISGSSAGAI VASIFCVHTT QEIPSLLTNV 240
  241 LNMEFNIFND DNSKSPNENL LIKISRFCQN GTWFNNQPLI NTMLSFLGNL TFREAYNKTG 300
  301 KILNITVSPA SIYEQPKLLN NLTAPNVLIW SAVCASCSLP GVFPSTPLFE KDPHTGKIKE 360
  361 WGATNLHLSN MKFMDGSVDN DMPISRLSEM FNVDHIIACQ VNIHVFPLLK FSNTCVGGEI 420
  421 EKEITARFRN QVTKIFKFFS DETIHFLDIL KELEFHPYLM TKLKHLFLQQ YSGNVTILPD 480
  481 LSMVGQFHEV LKNPSQLFLL HQTTLGARAT WPKISMIQNN CGQEFALDKA ITFLKEKIII 540
  541 SSSIKNPLQF YQPRFSEQIK SLSIMDADLP GVDLEESSSN SLSIIKSPNK TAAPGRFPLQ 600
  601 PLPSPSSTFN KRKMDMLSPS PSPSTSPQRS KSSFTQQGTR QKANSLSFAI GASSLRLKKS 660
  661 PLKVPSRPQF KKRSSYYNQN MSAEMRKNRK KSGTISSYDV QTNSEDFPIP AIENGSFDNT 720
  721 LFNPSRFPMD AMSAATNDNF MNNSDIFQN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HFM1 LYS4 NEW1 RBG1 SGD1 SOK1 SSZ1 TCB1 TGL5 TMA46 YEF3 YLR072W ZUO1
    View Details Qiu et al. (2008) DGA1 TGL1 TGL3 TGL4 TGL5 YEH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TAM41 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen DOT1 TGL5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TGL5 Huh WK, et al. (2003)
    View Data TGL5 and ERG6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..314] ORFEUS 7.19 Monomeric isocitrate dehydrogenase
    2 View Details [315..417] MSA 2.157991 View MSA. No confident structure predictions are available.
    3 View Details [418..749] MSA 1.075883 View MSA. No confident structure predictions are available.
    4 View Details [572..749] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phospholipase A2 activity
    		•  2.22630563405125 bayes_pls_golite062009
  • phospholipase activity
    		•  2.02363770793596 bayes_pls_golite062009
  • lipase activity
    		•  1.83391969295473 bayes_pls_golite062009
  • catalytic activity
    		•  1.681309422157 bayes_pls_golite062009
  • [acyl-carrier-protein] S-malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • S-malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • malonyltransferase activity
    		•  1.27314027329282 bayes_pls_golite062009
  • hydrolase activity
    		•  0.755660272658182 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.432469017757431 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.431665185524913 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.39017969987234 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  0.28475890150768 bayes_pls_golite062009
  • binding
    		•  0.112552746544258 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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