Protein Overview: ORC5

General Information:
Name(s) found:	ORC5 / YNL261W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|841421\|gb\|AAC49122.1\| origin recognition complex, subunit 5 [NCBI NR] gi\|6324068\|ref\|NP_014138.1\| Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; Orc5p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S61768 origin recognition complex chain ORC5 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1709491\|sp\|P50874.1\|ORC5_YEAST RecName: Full=Origin recognition complex subunit 5; AltName: Full=Origin recognition complex 53 kDa subunit [NCBI NR] gi\|1302315\|emb\|CAA96168.1\| ORC5 [Saccharomyces cerevisiae] [NCBI NR] gi\|1255957\|emb\|CAA65483.1\| ORC5 [Saccharomyces cerevisiae] [NCBI NR] Origin recognition complex subunit 5 OS=Saccharomyces cerevisiae GN=ORC5 PE=1 SV=1 [Swiss-Prot] ORC5 Origin recognition complex, 50 kDa subunit [mips] Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing [SGD] Chr XIV from 155099-156538 [yeastorf3.fasta] (P50874) Origin recognition complex subunit 5 (Origin recognition complex protein 53 kDa subunit) [4932.FASTACCERV.txt] ORC5, Chr XIV from 155099-156538 [yeast_orfs2] ORC5 SGDID:S0005205, Chr XIV from 155099-156538, Verified ORF [yeastflysequest.fasta] Orc5p [Saccharomyces cerevisiae]gi\|1255957\|emb\|CAA65483.1\| ORC5 [Saccharomyces cerevisiae]gi\|1302315\|emb\|CAA96168.1\| ORC5 [Saccharomyces cerevisiae]gi\|1709491\|sp\|P50874\|ORC5_YEAST Origin recognition complex subunit 5 (Origin recognition complex protein [nrdb_11152004_Chlamydomonas] ORC5 SGDID:S000005205, Chr XIV from 155101-156540, Verified ORF, "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ORC5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] origin recognition complex, subunit 5 [nr-271106-contam.fasta] Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; Orc5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Origin recognition complex subunit 5 (Origin recognition complex 53 kDa subunit) [nr-271106-contam.fasta] [chemostatdb.fasta] Origin recognition complex subunit 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ORC5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ORC5 SGDID:S000005205, Chr XIV from 155100-156539, Genome Release 64-1-1, Verified ORF, "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" [yeast-030211-contam.fasta] ORC5 SGDID:S000005205, Chr XIV from 155100-156539, Genome Release 64-2-1, Verified ORF, "Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" [20141208_orf_trans.fasta] TR8418\|c0_g1_i1\|g.6005 ORF TR8418\|c0_g1_i1\|g.6005 TR8418\|c0_g1_i1\|m.6005 type:complete len:480 (+) TR8418\|c0_g1_i1:158-1597(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YNL261W SGDID:S000005205, Chr XIV from 155100-156539, Genome Release 64-1-1, Verified ORF, "Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_5436\|g.3556 ORF ID=asmbl_5436\|g.3556 ID=asmbl_5436\|m.3556 type:complete len:480 (+) ID=asmbl_5436:158-1597(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	479 amino acids
Gene Ontology:
Cellular Component:	pre-replicative complex [TAS] nuclear origin of replication recognition complex [IDA][IMP]
Biological Process:	DNA replication initiation [TAS] pre-replicative complex assembly [TAS] chromatin silencing at silent mating-type cassette [TAS]
Molecular Function:	ATPase activity [TAS] DNA replication origin binding [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVTTPEVAF REYQTNCLAS YISADPDITP SNLILQGYSG TGKTYTLKKY FNANPNLHAV  60
   61 WLEPVELVSW KPLLQAIART VQYKLKTLYP NIPTTDYDPL QVEEPFLLVK TLHNIFVQYE 120
  121 SLQEKTCLFL ILDGFDSLQD LDAALFNKYI KLNELLPKDS KINIKFIYTM LETSFLQRYS 180
  181 THCIPTVMFP RYNVDEVSTI LVMSRCGELM EDSCLRKRII EEQITDCTDD QFQNVAANFI 240
  241 HLIVQAFHSY TGNDIFALND LIDFKWPKYV SRITKENIFE PLALYKSAIK LFLSTDDNLS 300
  301 ENGQGESAIT TNRDDLENSQ TYDLSIISKY LLIASYICSY LEPRYDASIF SRKTRIIQGR 360
  361 AAYGRRKKKE VNPRYLQPSL FAIERLLAIF QAIFPIQGKA ESGSLSALRE ESLMKANIEV 420
  421 FQNLSELHTL KLIATTMNKN IDYLSPKVRW KVNVPWEIIK EISESVHFNI SDYFSDIHE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		HAT1 HAT2 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6
View Details	(MIPS) Mewes HW, et al. (2004)		CDC45 CDC6 CDC7 DBF4 DPB11 DPB2 DPB3 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL31 POL32 SLD3
View Details	Krogan NJ, et al. (2006)		HAT1 HAT2 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SWE1 YJR154W
View Details	Gavin AC, et al. (2006)		ORC1 ORC2 ORC3 ORC4 ORC5 ORC6
View Details	Gavin AC, et al. (2002)		CDC45 ERG26 GLT1 HAT1 HSP42 LYS12 MCM2 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPD3 RPN9 SIN3 TFP1
View Details	Qiu et al. (2008)		CDC45 CDC6 DBF4 DPB11 DPB2 DPB3 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 POL2 POL3 POL31 POL32 SLD3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PDI1	ORC5	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	ORC5	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..191]	PSI-BLAST	29.69897	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
2	View Details	[192..354]	PSI-BLAST	29.69897	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
3	View Details	[355..479]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2