YRC Public Data Repository - Protein Structure Prediction

Protein:	ORC5
Organism:	Saccharomyces cerevisiae
Length:	479 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ORC5.

Description	E-value	Query Range	Subject Range
ORC5_MOUSE - Origin recognition complex subunit 5 OS=Mus musculus GN=Orc5 PE=2 SV=1	359.0	[0..8]	[476..8]
gi\|64174879, gi\|... - gi\|71610986\|dbj\|BAE16572.1\| Origin Recognition Complex subunit 5 [Cricetulus griseus], gi\|64174879\|g...	353.0	[0..5]	[476..5]
gi\|56788790, gi\|... - gi\|62079099\|ref\|NP_001014208.1\| origin recognition complex, subunit 5-like [Rattus norvegicus], gi\|5...	352.0	[0..8]	[476..8]
gi\|109067761 - gi\|109067761\|ref\|XP_001085300.1\| PREDICTED: similar to origin recognition complex subunit 5 isoform ...	351.0	[0..8]	[476..120]
gi\|114615275 - gi\|114615275\|ref\|XP_519292.2\| PREDICTED: origin recognition complex subunit 5 [Pan troglodytes]	350.0	[0..8]	[476..166]
gi\|73981959 - gi\|73981959\|ref\|XP_852382.1\| PREDICTED: similar to origin recognition complex subunit 5 isoform 1 [C...	349.0	[0..8]	[476..180]
ENSPTRT00000036226 - null ORC5L - origin recognition complex, subunit 5-like (yeast) gi\|123982918, gi... - gi\|123997599\|gb\|ABM86401.1\| origin recognition complex, subunit 5-like (yeast) [synthetic construct]...	341.0	[0..8]	[476..8]
gi\|220948078, gi... - gi\|220957326\|gb\|ACL91206.1\| Orc5-PA [synthetic construct], gi\|220948078\|gb\|ACL86582.1\| Orc5-PA [synt... Orc5-PA - The gene Origin recognition complex subunit 5 is referred to in FlyBase by the symbol Dmel\Orc5 (CG7...	331.0	[0..3]	[476..7]

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Predicted Domain #1

Region A:
Residues: [1-191]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVTTPEVAF REYQTNCLAS YISADPDITP SNLILQGYSG TGKTYTLKKY FNANPNLHAV  60
   61 WLEPVELVSW KPLLQAIART VQYKLKTLYP NIPTTDYDPL QVEEPFLLVK TLHNIFVQYE 120
  121 SLQEKTCLFL ILDGFDSLQD LDAALFNKYI KLNELLPKDS KINIKFIYTM LETSFLQRYS 180
  181 THCIPTVMFP R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.69897
Match:	1e32A
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [192-354]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNVDEVSTIL VMSRCGELME DSCLRKRIIE EQITDCTDDQ FQNVAANFIH LIVQAFHSYT  60
   61 GNDIFALNDL IDFKWPKYVS RITKENIFEP LALYKSAIKL FLSTDDNLSE NGQGESAITT 120
  121 NRDDLENSQT YDLSIISKYL LIASYICSYL EPRYDASIFS RKT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.69897
Match:	1e32A
Description:	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [355-479]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIIQGRAAYG RRKKKEVNPR YLQPSLFAIE RLLAIFQAIF PIQGKAESGS LSALREESLM  60
   61 KANIEVFQNL SELHTLKLIA TTMNKNIDYL SPKVRWKVNV PWEIIKEISE SVHFNISDYF 120
  121 SDIHE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits