Protein Overview: MKS1

General Information:
Name(s) found:	MKS1 / YNL076W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|791108\|emb\|CAA60182.1\| negative regulator of ras cAMP pathaway [Saccharomyces cerevisiae] [NCBI NR] gi\|6324253\|ref\|NP_014323.1\| Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling; Mks1p [Saccharomyces cerevisiae] [NCBI NR] gi\|1346541\|sp\|P34072.2\|MKS1_YEAST RecName: Full=Negative regulator of RAS-cAMP pathway [NCBI NR] gi\|1301965\|emb\|CAA95950.1\| MKS1 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S53902 regulatory protein MKS1 - yeast (Saccharomyces cerevisiae) [NCBI NR] Negative regulator of RAS-cAMP pathway OS=Saccharomyces cerevisiae GN=MKS1 PE=1 SV=2 [Swiss-Prot] MKS1 Pleiotropic regulatory factor [mips] Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling [SGD] MKS1, Chr XIV from 483553-485307 [yeast_orfs2] Chr XIV from 483553-485307 [yeastorf3.fasta] (P34072) Negative regulator of RAS-cAMP pathway [4932.FASTACCERV.txt] MKS1 SGDID:S0005020, Chr XIV from 483555-485309, Verified ORF [yeastflysequest.fasta] Mks1p [Saccharomyces cerevisiae]gi\|791108\|emb\|CAA60182.1\| negative regulator of ras cAMP pathaway [Saccharomyces cerevisiae]gi\|1301965\|emb\|CAA95950.1\| MKS1 [Saccharomyces cerevisiae]gi\|1078149\|pir\|\|S53902 regulatory protein MKS1 - yeast (Saccharomyces [nrdb_11152004_Chlamydomonas] MKS1 SGDID:S000005020, Chr XIV from 483557-485311, Verified ORF, "Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] MKS1 SGDID:S000005020, Chr XIV from 483557-485311, Verified ORF, "Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] MKS1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling; Mks1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] negative regulator of ras cAMP pathaway [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Negative regulator of RAS-cAMP pathway [nr-271106-contam.fasta] MKS1 SGDID:S000005020, Chr XIV from 483558-485312, Verified ORF, "Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] Negative regulator of RAS-cAMP pathway OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MKS1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MKS1 SGDID:S000005020, Chr XIV from 483556-485310, Genome Release 64-1-1, Verified ORF, "Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling" [yeast-030211-contam.fasta] MKS1 SGDID:S000005020, Chr XIV from 483556-485310, Genome Release 64-2-1, Verified ORF, "Pleiotropic negative transcriptional regulator; involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling" [20141208_orf_trans.fasta] YNL076W SGDID:S000005020, Chr XIV from 483556-485310, Genome Release 64-1-1, Verified ORF, "Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	584 amino acids
Gene Ontology:
Cellular Component:	intracellular [IC]
Biological Process:	regulation of nitrogen utilization [IMP] mitochondria-nucleus signaling pathway [IPI]
Molecular Function:	transcription repressor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSREAFDVPN IGTNKFLKVT PNLFTPERLN LFDDVELYLT LIKASKCVEQ GERLHNISWR  60
   61 ILNKAVLKEH NINRSKKRDG VKNIYYVLNP NNKQPIKPKQ AAVKQPPLQK ANLPPTTAKQ 120
  121 NVLTRPMTSP AIAQGAHDRS LDNPNSTNND VKNDVAPNRQ FSKSTTSGLF SNFADKYQKM 180
  181 KNVNHVANKE EPQTIITGFD TSTVITKKPL QSRRSRSPFQ HIGDMNMNCI DNETSKSTSP 240
  241 TLENMGSRKS SFPQKESLFG RPRSYKNDQN GQLSLSKTSS RKGKNKIFFS SEDEDSDWDS 300
  301 VSNDSEFYAD EDDEEYDDYN EEEADQYYRR QWDKLLFAKN QQNLDSTKSS VSSANTINSN 360
  361 TSHDPVRKSL LSGLFLSEAN SNSNNHNTAH SEYASKHVSP TPQSSHSNIG PQPQQNPPSA 420
  421 NGIKQQKPSL KTSNVTALAS LSPPQPSNNE RLSMDIQKDF KTDNESNHLY ESNAPLTAQT 480
  481 ILPTALSTHM FLPNNIHQQR MAIATGSNTR HRFSRRQSMD IPSKNRNTGF LKTRMEISEE 540
  541 EKMVRTISRL DNTSIANSNG NGNDDTSNQR TEALGRKTSN GGRI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		MKS1 RTG2 YNL208W
View Details	Gavin AC, et al. (2006)		GLN1 MCM2 MKS1 RTG2 TSC10
View Details	Gavin AC, et al. (2002)		CTR3 DAL3 GLN1 GTO3 IML1 MCM2 MKS1 REG1 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 YIL177C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	MKS1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..584]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: MKS1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: