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Protein Overview: SFB2

General Information:
Name(s) found: SFB2 / YNL049C [SGD]
Description(s) found:
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  • gi|6324279|ref|NP_014349.1| Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy; Sfb2p [Saccharomyces cerevisi [NCBI NR]
  • gi|51013107|gb|AAT92847.1| YNL049C [Saccharomyces cerevisiae] [NCBI NR]
  • gi|3355837|emb|CAA08830.1| Sfb2 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S62152 SFB2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730731|sp|P53953.1|SFB2_YEAST RecName: Full=SED5-binding protein 2; AltName: Full=SEC24-related protein 2 [NCBI NR]
  • gi|1301909|emb|CAA95918.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1098489|gb|AAA99663.1| Ynl2505p [NCBI NR]
  • SED5-binding protein 2 OS=Saccharomyces cerevisiae GN=SFB2 PE=1 SV=1 [Swiss-Prot]
  • SFB2 Probable component of COPII coated vesicles that binds to Sec23p, involved in ER to Golgi transport and in autophagy [mips]
  • Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p [SGD]
  • SFB2, Chr XIV from 535277-537907, reverse complement [yeast_orfs2]
  • Chr XIV from 535277-537907, reverse complement [yeastorf3.fasta]
  • Chr XIV from 537907-535277, reverse complement [yeastorf5.fasta]
  • (P53953) SED5-binding protein 2 (SEC24-related protein 2) [4932.FASTACCERV.txt]
  • SFB2 SGDID:S0004994, Chr XIV from 537909-535279, reverse complement, Verified ORF [yeastflysequest.fasta]
  • SFB2 SGDID:S0004994, Chr XIV from 537910-535280, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy [Saccharomyces cerevisiae]gi|51013107|gb|AAT92847.1| YNL0 [nrdb_11152004_Chlamydomonas]
  • SFB2 SGDID:S000004994, Chr XIV from 537912-535282, reverse complement, Verified ORF, "Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Sfb2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy; Sfb2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SED5-binding protein 2 (SEC24-related protein 2) [nr-271106-contam.fasta]
  • YNL049C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ynl2505p [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SFB2 SGDID:S000004994, Chr XIV from 537913-535283, reverse complement, Verified ORF, "Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • SFB2 SGDID:S000004994, Chr XIV from 537912-535282, reverse complement, Verified ORF, "Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • SFB2 SGDID:S000004994, Chr XIV from 537913-535283, reverse complement, Verified ORF, "Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy" [SGDyeast.20101221.fasta]
  • SED5-binding protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SFB2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SFB2 SGDID:S000004994, Chr XIV from 537911-535281, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p" [yeast-030211-contam.fasta]
  • SFB2 SGDID:S000004994, Chr XIV from 537911-535281, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNL049C SGDID:S000004994, Chr XIV from 537911-535281, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 876 amino acids

    Gene Ontology:
    Cellular Component: COPII vesicle coat [IPILink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHHKKRVYP QAQVPYIASM PIVAEQQQSQ QQIDQTAYAM GNLQLNNRAN SFTQLAQNQQ  60
   61 FPGSGKVVNQ LYPVDLFTEL PPPIRDLSLP PLPITISQDN IVTPSEYSNV PYQYVRSTLK 120
  121 AVPKTNSLLK KTKLPFAIVI RPYLHLQDSD NQVPLNTDGV IVRCRRCRSY MNPFVVFINQ 180
  181 GRKWQCNICR FKNDVPFGFD QNLQGAPINR YERNEIKNSV VDYLAPVEYS VREPPPSVYV 240
  241 FLLDVSQNAV KNGLLATSAR TILENIEFLP NHDGRTRIAI ICVDHSLHYF YVPLDDDYEV 300
  301 SDEDDEESDG EEEDEDEEEE DVDNSETIQM FDIGDLDEPF LPMPSDELVV PLKYCKNNLE 360
  361 TLLKKIPEIF QDTHSSKFAL GPALKAASNL IKSTGGKVEV ISSTLPNTGI GKLKKRSEQG 420
  421 ILNTPKESSQ LLSCKDSFYK TFTIECNKLQ ITVDMFLASE DYMDVATLSH LGRFSGGQTH 480
  481 FYPGFNATSL NDVTKFTREL SRHLSMDISM EAVMRVRCST GLRATSFFGH FFNRSSDLCA 540
  541 FSTMPRDQSY LFGISIEDSL MAEYCYLQVS TLLTLNTGER RIRVMTLALP TSESAREVFA 600
  601 SADQLAITDF MTQNAVTKAL NSSMYSARDF ITKSLEDILN AYKKEISMSN INSVTSLNLC 660
  661 ANLRMLPLLM NGLSKHIALR PGVVPSDYRA SALNRLETEP LHYLIKSIYP TVYSLHDMPD 720
  721 EVGLPDFEGK TVLPEPINAT ISLFERYGLY LIDNSAELFL WVGGDAVPEL LIDVFNTDTI 780
  781 SQIPVGKSEL PLLNDSPFNE RLRRIIGRIR ENNDTITFQS LYIIRGPSIN EPANLNSEKD 840
  841 MASLRLWVLS TLVEDKVLNC ASYREYLQSM KTSINR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) SEC16 SEC23 SFB2
    View Details Krogan NJ, et al. (2006) BUG1 GRH1 SEC23 SEC24 SFB2
    View Details Gavin AC, et al. (2006) SEC13 SEC16 SEC23 SEC24 SFB2
    View Details Qiu et al. (2008) ERV25 SAR1 SEC13 SEC16 SEC23 SEC24 SEC31 SFB2 SFB3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SFB2 Huh WK, et al. (2003)
    View Data SFB2 and SEC13 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] ORFEUS 9.57 RBP1
    2 View Details [216..543] ORFEUS 7.23 von Willebrand factor A3 domain, vWA3
    3 View Details [544..728] deduced N/A No confident structure predictions are available.
    4 View Details [729..793] PSI-BLAST 2.69897 Severin, domain 2
    5 View Details [794..876] ORFEUS 11.02 Sec24

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.9315281375853 bayes_pls_golite062009
  • binding
    		•  1.90456497151578 bayes_pls_golite062009
  • transporter activity
    		•  1.30184925420876 bayes_pls_golite062009
  • collagen binding
    		•  0.568860931913098 bayes_pls_golite062009
  • integrin binding
    		•  0.56855067092085 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.464562340940318 bayes_pls_golite062009
  • protein complex binding
    		•  0.35582708645524 bayes_pls_golite062009
  • DNA binding
    		•  0.155617838235236 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0661625326929309 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.027305897174472 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0179622467180781 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0153681945260867 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle