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View Structure Prediction Details

Protein: SFB2
Organism: Saccharomyces cerevisiae
Length: 876 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SFB2.

Description E-value Query
Range
Subject
Range
SFB2_YEAST - SED5-binding protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SFB2 PE=1 SV=1
SFB2 - Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection du...
0.0 [1..876] [1..876]
SEC24A - SEC24 family, member A (S. cerevisiae)
0.0 [15..876] [272..1078]
SPAC22F8.08 - COPII vesicle coat protein
SEC24_SCHPO - Protein transport protein sec24 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sec24 PE=2...
0.0 [2..875] [87..925]
SC24C_ARATH - Protein transport protein Sec24-like CEF OS=Arabidopsis thaliana GN=CEF PE=2 SV=3
0.0 [2..875] [274..1092]
gi|7271162 - gi|7271162|emb|CAB81549.1| putative Sec23 protein [Drosophila melanogaster]
0.0 [107..839] [9..754]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHHKKRVYP QAQVPYIASM PIVAEQQQSQ QQIDQTAYAM GNLQLNNRAN SFTQLAQNQQ  60
   61 FPGSGKVVNQ LYPVDLFTEL PPPIRDLSLP PLPITISQDN IVTPSEYSNV PYQYVRSTLK 120
  121 AVPKTNSLLK KTKLPFAIVI RPYLHLQDSD NQVPLNTDGV IVRCRRCRSY MNPFVVFINQ 180
  181 GRKWQCNICR FKNDVPFGFD QNLQGAPINR YERNE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.57
Match: 1k83A
Description: RBP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.9315281375853 bayes_pls_golite062009
binding 1.90456497151578 bayes_pls_golite062009
transporter activity 1.30184925420876 bayes_pls_golite062009
collagen binding 0.568860931913098 bayes_pls_golite062009
integrin binding 0.56855067092085 bayes_pls_golite062009
nucleic acid binding 0.464562340940318 bayes_pls_golite062009
protein complex binding 0.35582708645524 bayes_pls_golite062009
DNA binding 0.155617838235236 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0661625326929309 bayes_pls_golite062009
pyrophosphatase activity 0.027305897174472 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0179622467180781 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0153681945260867 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [216-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKNSVVDYLA PVEYSVREPP PSVYVFLLDV SQNAVKNGLL ATSARTILEN IEFLPNHDGR  60
   61 TRIAIICVDH SLHYFYVPLD DDYEVSDEDD EESDGEEEDE DEEEEDVDNS ETIQMFDIGD 120
  121 LDEPFLPMPS DELVVPLKYC KNNLETLLKK IPEIFQDTHS SKFALGPALK AASNLIKSTG 180
  181 GKVEVISSTL PNTGIGKLKK RSEQGILNTP KESSQLLSCK DSFYKTFTIE CNKLQITVDM 240
  241 FLASEDYMDV ATLSHLGRFS GGQTHFYPGF NATSLNDVTK FTRELSRHLS MDISMEAVMR 300
  301 VRCSTGLRAT SFFGHFFNRS SDLCAFST

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.23
Match: 1fe8A
Description: von Willebrand factor A3 domain, vWA3
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [544-728]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRDQSYLFG ISIEDSLMAE YCYLQVSTLL TLNTGERRIR VMTLALPTSE SAREVFASAD  60
   61 QLAITDFMTQ NAVTKALNSS MYSARDFITK SLEDILNAYK KEISMSNINS VTSLNLCANL 120
  121 RMLPLLMNGL SKHIALRPGV VPSDYRASAL NRLETEPLHY LIKSIYPTVY SLHDMPDEVG 180
  181 LPDFE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [729-793]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKTVLPEPIN ATISLFERYG LYLIDNSAEL FLWVGGDAVP ELLIDVFNTD TISQIPVGKS  60
   61 ELPLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.69897
Match: 1svq__
Description: Severin, domain 2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [794-876]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDSPFNERLR RIIGRIRENN DTITFQSLYI IRGPSINEPA NLNSEKDMAS LRLWVLSTLV  60
   61 EDKVLNCASY REYLQSMKTS INR

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 11.02
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle