Protein Overview: XYL2

General Information:
Name(s) found:	XYL2 / YLR070C [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect [SGD]
Organism:	Saccharomyces cerevisiae
Length:	356 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	monosaccharide metabolic process [IDA]
Molecular Function:	D-xylulose reductase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDLTTQEAI VLERPGKITL TNVSIPKISD PNEVIIQIKA TGICGSDIHY YTHGRIANYV  60
   61 VESPMVLGHE SSGIVALIGE NVKTLKVGDR VALEPGIPDR FSPEMKEGRY NLDPNLKFAA 120
  121 TPPFDGTLTK YYKTMKDFVY KLPDDVSFEE GALIEPLSVA IHANKLAKIK FGARCVVFGA 180
  181 GPIGLLAGKV ASVFGAADVV FVDLLENKLE TARQFGATHI VNSGDLPHGV TVDSVIKKAI 240
  241 GKKGADVVFE CSGAEPCVRA GIEVCKAGGT IVQVGMGQEE IQFPISIIPT KELTFQGCFR 300
  301 YCQGDYSDSI ELVSSRKLSL KPFITHRYSF KDAVEAFEET SHHPLNNIKT IIEGPE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SAM35	XYL2	1	Unpublished Fields Lab Data
View Screen	UTP9	XYL2	1	Unpublished Fields Lab Data
View Screen	PEX1	XYL2	1	Unpublished Fields Lab Data
View Screen	LOS1	XYL2	1	Unpublished Fields Lab Data
View Screen	UBI4	XYL2	1	Unpublished Fields Lab Data
View Screen	CTF3	XYL2	1	Unpublished Fields Lab Data
View Screen	TEM1	XYL2	1	Unpublished Fields Lab Data
View Screen	APC5	XYL2	1	Unpublished Fields Lab Data
View Screen	RPN7	XYL2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..155] [323..356]	PSI-BLAST	834.68867	Ketose reductase (sorbitol dehydrogenase)
2	View Details	[156..322]	PSI-BLAST	834.68867	Ketose reductase (sorbitol dehydrogenase)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
ethanol binding	4.47659026306883	bayes_pls_golite062009
NAD or NADH binding	4.35058438816264	bayes_pls_golite062009
retinol dehydrogenase activity	4.1750549780559	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
L-iditol 2-dehydrogenase activity	3.00103406168296	bayes_pls_golite062009
alcohol binding	2.97042200128883	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.89007863838685	bayes_pls_golite062009
all-trans retinal binding	2.84803957533249	bayes_pls_golite062009
S-(hydroxymethyl)glutathione dehydrogenase activity	2.58673703881996	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADH) activity	2.2999175117758	bayes_pls_golite062009
hydroxymethylfurfural reductase activity	2.2999175117758	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	2.03039843216597	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
retinoid binding	1.54383322726845	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
isoprenoid binding	1.42961392805059	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	1.38219425408212	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	1.29842732066898	bayes_pls_golite062009
chaperone binding	1.19079350615542	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	1.07006097264025	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.01627645289834	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.527946013169731	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.484089941059577	bayes_pls_golite062009
kinase activity	0.461063813999598	bayes_pls_golite062009
hydrolase activity	0.41684292392606	bayes_pls_golite062009
L-arabinitol 2-dehydrogenase activity	0.382131941157781	bayes_pls_golite062009
hydroxymethylfurfural reductase (NADPH) activity	0.382131941157781	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.375415252607746	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	0.361275519814065	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
protein kinase activity	0.339420053437627	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	0.320177384202291	bayes_pls_golite062009
glyceraldehyde-3-phosphate dehydrogenase activity	0.298691872199351	bayes_pls_golite062009
ATPase activity	0.275256680720412	bayes_pls_golite062009
nucleic acid binding	0.274019118261823	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.250698007650211	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
DNA binding	0.164288600669795	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.87

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2