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Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: S-(hydroxymethyl)glutathione dehydrogenase activity
Acc: GO:0051903
Aspect: Molecular Function
Desc: Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+.
Synonyms:
  • NAD-dependent formaldehyde dehydrogenase activity
  • FDH activity
  • NAD-linked formaldehyde dehydrogenase activity
  • ADH3 activity
  • chi-ADH activity
  • S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity
  • formic dehydrogenase activity
  • GS-FDH activity
  • glutathione-dependent formaldehyde dehydrogenase activity
  • class III alcohol dehydrogenase activity
  • NAD- and glutathione-dependent formaldehyde dehydrogenase activity
  • GD-FALDH activity
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 8 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051903 - S-(hydroxymethyl)glutathione dehydrogenase activity (interactive image map)
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