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Protein Overview: COX12

General Information:
Name(s) found: COX12 / YLR038C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 83 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial respiratory chain complex IV [IPILink to PubMed article]
    Biological Process: respiratory chain complex IV assembly [IMPLink to PubMed article]
    Molecular Function: cytochrome-c oxidase activity [IDALink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADQENSPLH TVGFDARFPQ QNQTKHCWQS YVDYHKCVNM KGEDFAPCKV FWKTYNALCP  60
   61 LDWIEKWDDQ REKGIFAGDI NSD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX6 COX7 COX8 COX9
    View Details Qiu et al. (2008) ATP14 ATP15 ATP17 ATP20 ATP5 ATP7 COB COX1 COX12 COX17 COX19 COX2 COX3 COX4 COX5A COX6 COX8 COX9 QCR7

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPO12 COX12 1 Unpublished Fields Lab Data
    View Screen THP2 COX12 1 Unpublished Fields Lab Data
    View Screen STE3 COX12 1 Unpublished Fields Lab Data
    View Screen TAM41 COX12 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data COX12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..83] PSI-BLAST 187.512579 Cytochrome c oxidase subunit h

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytochrome-c oxidase activity
    		•  4.43411953394546 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors
    		•  4.43411953394546 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors, oxygen as acceptor
    		•  4.43411953394546 bayes_pls_golite062009
  • heme-copper terminal oxidase activity
    		•  4.19888886424808 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.981765859404114 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle