Protein Overview: SRS2

General Information:
Name(s) found:	SRS2 / YJL092W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|83305803\|sp\|P12954.2\|SRS2_YEAST RecName: Full=ATP-dependent DNA helicase SRS2 [NCBI NR] gi\|6322369\|ref\|NP_012443.1\| DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous r [NCBI NR] gi\|521096\|emb\|CAA54361.1\| RADH [Saccharomyces cerevisiae] [NCBI NR] gi\|4277\|emb\|CAA33706.1\| helicase [Saccharomyces cerevisiae] [NCBI NR] pir\|\|HJBYDH helicase (EC 3.6.1.-) HPR5 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1008264\|emb\|CAA89385.1\| HPR5 [Saccharomyces cerevisiae] [NCBI NR] ATP-dependent DNA helicase SRS2 OS=Saccharomyces cerevisiae GN=SRS2 PE=1 SV=2 [Swiss-Prot] HPR5 ATP-dependent DNA helicase [mips] DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability [SGD] HPR5, Chr X from 257119-260643 [yeast_orfs2] Chr X from 257119-260643 [yeastorf3.fasta] HPR5 SGDID:S0003628, Chr X from 257339-260863, Verified ORF [yeastflysequest.fasta] DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc28p substrate [Saccharomyces cerevisiae]gi\|1008264\|emb\|CAA89385. [nrdb_11152004_Chlamydomonas] HPR5 SGDID:S000003628, Chr X from 257339-260863, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc2 [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] HPR5 SGDID:S000003628, Chr X from 257418-260942, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc2 [yeast-contam.fasta] SRS2 SGDID:S000003628, Chr X from 257418-260942, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] SRS2 SGDID:S000003628, Chr X from 257417-260941, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by [yeast-200209-contam.fasta] SRS2 SGDID:S000003628, Chr X from 257417-260941, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat [SGD_S-cerevisiae_na_05-08-2009_con_reversed.fasta] helicase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ATP-dependent DNA helicase SRS2 [nr-271106-contam.fasta] HPR5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] RADH [Saccharomyces cerevisiae] [nr-271106-contam.fasta] DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc28p substrate; Hpr5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SRS2 SGDID:S000003628, Chr X from 257417-260941, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by suppressing unscheduled homologous recombination" [yeast-bovrabprots.fasta] SRS2 SGDID:S000003628, Chr X from 257417-260941, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability" [scerevisihumanrev.fasta] HPR5 SGDID:S000003628, Chr X from 257418-260942, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, required for proper timing of commitment to meiotic recombination and the transition from Meiosis I to Meiosis II; potential Cdc28p substrate" [yeast-contam_custom.fasta] [chemostatdb.fasta] ATP-dependent DNA helicase SRS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRS2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SRS2 SGDID:S000003628, Chr X from 257423-260947, Genome Release 64-1-1, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability" [yeast-030211-contam.fasta] SRS2 SGDID:S000003628, Chr X from 257423-260947, Genome Release 64-2-1, Verified ORF, "DNA helicase and DNA-dependent ATPase; involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; functional homolog of human RTEL1" [20141208_orf_trans.fasta] YJL092W SGDID:S000003628, Chr X from 257423-260947, Genome Release 64-1-1, Verified ORF, "DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	1174 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS]
Biological Process:	DNA repair [IGI] double-strand break repair via nonhomologous end joining [IDA]
Molecular Function:	DNA helicase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNNDLWLH LVSQLNTQQR AAALFDYTRG LQVIAGPGTG KTKVLTSRVA YLILHHHIHP  60
   61 RDIIVTTFTN KAANEMKERL QEMLRGAGVN ISELLIGTFH SICLKILYRF GHLVDLQKDW 120
  121 RIIDEKEIDV ILDDMIEKVP DQIRDYASSI TRKVNLCMPS KNGDEWTIHP KLIKKQISKL 180
  181 KSNAILPEEY ILDSNHDAAL GYFYQIYQSE LSKKNTLDFD DLLMYTFRLL TRVRVLSNIK 240
  241 HVLVDEFQDT NGIQLDLMFL FAKGNHHLSR GMTIVGDPDQ SIYAFRNALA HNFLEMGRKC 300
  301 PIEYSTIILV ENYRSSQKIL NTSEILITQQ NKGRQNRAPL RAQFDLDFPP VYMNFPAYFL 360
  361 EAPSLVRELL YLKALPNLFT FNDFAILVRQ RRQIKRIESA LIEHRIPYKI IRGHSFWDSK 420
  421 ETRAMLNLLK LIFSPNDKHA ILASLLYPAR GLGPATGEKI KNALDTLATD VSCFQILKDI 480
  481 SSKKIMLDIP TKGRSVIADF ISMIENCQLL LQSTLLGGLS DLFDKLYELS GLKYEYLYKD 540
  541 GKKKNDQLEK SEPNLLNARH KNIELLKNYF LALLSKSESS DKEKNEAIKA ATDEAEPIEN 600
  601 KVITPKEYLR NFFNSLSLHS DAAEEEESES NKDAKIKREK NGFVTISTIH GAKGLEWPVV 660
  661 FIPGCEEGII PCVFNDDKKD ESEEDEEEDQ ENSKKDASPK KTRVLSVEDS IDEERRMFFV 720
  721 AQTRAKYLLY LSNTVTVEDV DRPRIASRFL TTDLIKAMSD SQKLFESTNS IKKLYRILNK 780
  781 KPPAEDDKLF SLDQLRKDYN QFIENRRERM IWQGIQMNDV YGIQLSRNKL LGSVSDFTSA 840
  841 ADQLRLETQN SIFPQKKLIE KSRPSKINGN YAPKSRVKSP EKRYAPETTS FHSPTKKKVY 900
  901 APQYVSTTNV PSRQEFHSST GKNIPFLRRE DRSITDISPR SSTRSLKGAS PNKTSHMSDD 960
  961 LMRPSPTRKD KVTRNIHFAT AGTFRIETQS NVDELHPPEY SNKSGQSLTS SEFSGFSSAC1020
 1021 SNSDQPTNLI EDINNELDLS DEELLNDISI ERRRELLGSK KTKKIKPKTR NRKSKRGDKV1080
 1081 KVEEVIDLKS EFEEDDSRNT TAAELLHNPD DTTVDNRPII SNAKFLADAA MKKTQKFSKK1140
 1141 VKNEPASSQM DIFSQLSRAK KKSKLNNGEI IVID

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ACO1 BAT2 HSP42 NTH2 RRP12 SRS2 SSE2
View Details	Ho Y, et al. (2002)		DUN1 SEC23 SEC53 SRS2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CAB3	No Comments	Hazbun TR, et al. (2003)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#14 Mitotic Prep2-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	SRS2	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..313]	PSI-BLAST	715.9691	DEXX box DNA helicase
2	View Details	[314..839]	PSI-BLAST	715.9691	DEXX box DNA helicase
3	View Details	[840..1174]	ORFEUS	10.98	Fibrinogen

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.82

Protein Overview: SRS2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: