Protein Overview: LYS1

General Information:
Name(s) found:	LYS1 / YIR034C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|82654956\|sp\|P38998.3\|LYS1_YEAST RecName: Full=Saccharopine dehydrogenase [NAD+, L-lysine-forming]; Short=SDH; AltName: Full=Lysine--2-oxoglutarate reductase [NCBI NR] gi\|6322225\|ref\|NP_012300.1\| Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; Lys1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S48496 saccharopine dehydrogenase (NAD, L-lysine-forming) (EC 1.5.1.7) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|557840\|emb\|CAA86194.1\| lys1 [Saccharomyces cerevisiae] [NCBI NR] Saccharopine dehydrogenase [NAD+, L-lysine-forming] OS=Saccharomyces cerevisiae GN=LYS1 PE=1 SV=3 [Swiss-Prot] LYS1 Saccharopine dehydrogenase [mips] Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway [SGD] LYS1, Chr IX from 419612-420733, reverse complement [yeast_orfs2] Chr IX from 419612-420733, reverse complement [yeastorf3.fasta] Chr IX from 420733-419612, reverse complement [yeastorf5.fasta] LYS1 SGDID:S0001473, Chr IX from 420733-419612, reverse complement, Verified ORF [yeastflysequest.fasta] Lys1p [Saccharomyces cerevisiae]gi\|557840\|emb\|CAA86194.1\| lys1 [Saccharomyces cerevisiae]gi\|630085\|pir\|\|S48496 saccharopine dehydrogenase (NAD, L-lysine-forming) (EC 1.5.1.7) - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] LYS1 SGDID:S000001473, Chr IX from 420733-419612, reverse complement, Verified ORF, "Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Saccharopine dehydrogenase [NAD+, L-lysine-forming] (Lysine--2-oxoglutarate reductase) (SDH) [nr-271106-contam.fasta] lys1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; Lys1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LYS1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] LYS1 SGDID:S000001473, Chr IX from 420736-419615, Genome Release 64-1-1, reverse complement, Verified ORF, "Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity" [yeast-030211-contam.fasta] LYS1 SGDID:S000001473, Chr IX from 420736-419615, Genome Release 64-2-1, reverse complement, Verified ORF, "Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity" [20141208_orf_trans.fasta] YIR034C SGDID:S000001473, Chr IX from 420736-419615, Genome Release 64-1-1, reverse complement, Verified ORF, "Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	373 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	lysine biosynthetic process via aminoadipic acid [NAS][TAS]
Molecular Function:	saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVTLHLRA ETKPLEARAA LTPTTVKKLI AKGFKIYVED SPQSTFNINE YRQAGAIIVP  60
   61 AGSWKTAPRD RIIIGLKEMP ETDTFPLVHE HIQFAHCYKD QAGWQNVLMR FIKGHGTLYD 120
  121 LEFLENDQGR RVAAFGFYAG FAGAALGVRD WAFKQTHSDD EDLPAVSPYP NEKALVKDVT 180
  181 KDYKEALATG ARKPTVLIIG ALGRCGSGAI DLLHKVGIPD ANILKWDIKE TSRGGPFDEI 240
  241 PQADIFINCI YLSKPIAPFT NMEKLNNPNR RLRTVVDVSA DTTNPHNPIP IYTVATVFNK 300
  301 PTVLVPTTAG PKLSVISIDH LPSLLPREAS EFFSHDLLPS LELLPQRKTA PVWVRAKKLF 360
  361 DRHCARVKRS SRL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		BCY1 CAR2 CYS4 FOL2 GND1 GTO1 LAA1 LYS1 POR1 SAH1 SNO2 SSN8 TAL1 THI22 THO2 TIF1, TIF2 TPK2 TPK3 VPS21 YBR028C YCK1 YCK2 YCK3 YGR111W YPT53

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	LYS1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..135] [324..373]	PSI-BLAST	81.69897	L-alanine dehydrogenase
2	View Details	[136..323]	PSI-BLAST	81.69897	L-alanine dehydrogenase

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.87

Protein Overview: LYS1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: