YRC Public Data Repository - Protein Structure Prediction

Protein:	LYS1
Organism:	Saccharomyces cerevisiae
Length:	373 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYS1.

Description	E-value	Query Range	Subject Range
LYS1_YEAST - Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Saccharomyces cerevisiae (strain ATCC 20450... gi\|151943194 - gi\|151943194\|gb\|EDN61529.1\| lysine requiring protein [Saccharomyces cerevisiae YJM789] LYS1 - Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-l... gi\|207344204 - gi\|207344204\|gb\|EDZ71423.1\| YIR034Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190406190 - gi\|190406190\|gb\|EDV09457.1\| saccharopine dehydrogenase [Saccharomyces cerevisiae RM11-1a]	0.0	[1..373]	[1..373]
LYS1_CANAX - Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Candida albicans GN=LYS1 PE=3 SV=1	0.0	[3..369]	[5..381]
LYS1_YARLI - Saccharopine dehydrogenase [NAD+, L-lysine-forming] OS=Yarrowia lipolytica GN=LYS5 PE=3 SV=1 LYS1_YARLI - Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Yarrowia lipolytica (strain CLIB 122 / E 15...	0.0	[2..367]	[3..367]
LYS1_SCHPO - Saccharopine dehydrogenase [NAD(+), L-lysine-forming] OS=Schizosaccharomyces pombe (strain 972 / ATC... lys3 - saccharopine dehydrogenase [NAD+, L-lysine forming]	3.0E-99	[1..367]	[1..368]
DHA2_STAAN - Alanine dehydrogenase 2 OS=Staphylococcus aureus (strain N315) GN=ald2 PE=1 SV=1 gi\|25284722 - pir\|\|A89955 alanine dehydrogenase [imported] - Staphylococcus aureus (strain N315)	2.0E-95	[5..364]	[2..350]
DHA2_STAAM - Alanine dehydrogenase 2 OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=ald2 PE=3 SV=1 gi\|156722161, gi... - gi\|156980026\|ref\|YP_001442285.1\| alanine dehydrogenase [Staphylococcus aureus subsp. aureus Mu3], gi... gi\|255006494 - gi\|255006494\|ref\|ZP_05145095.2\| alanine dehydrogenase [Staphylococcus aureus subsp. aureus Mu50-omeg...	3.0E-95	[5..364]	[2..350]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	7.0E-95	[5..364]	[2..350]
gi\|1742643, gi\|8... - gi\|89108444\|ref\|AP_002224.1\| pyridine nucleotide transhydrogenase, alpha subunit [Escherichia coli s... gi\|124529242, gi... - gi\|124529242\|ref\|ZP_01700317.1\| NAD(P) transhydrogenase, alpha subunit [Escherichia coli B], gi\|1245... EG10744 - pyridine nucleotide transhydrogenase, alpha subunit / Proton-translocating NAD(P) transhydrogenase, ... gi\|157066743, gi... - gi\|157161063\|ref\|YP_001458381.1\| NAD(P) transhydrogenase subunit alpha [Escherichia coli HS], gi\|157... gi\|238900819, gi... - gi\|238900819\|ref\|YP_002926615.1\| pyridine nucleotide transhydrogenase, alpha subunit [Escherichia co... gi\|169754972, gi... - gi\|170020044\|ref\|YP_001724998.1\| NAD(P) transhydrogenase subunit alpha [Escherichia coli ATCC 8739],... PNTA_ECOLI - NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase subunit alp... gi\|188492718, gi... - gi\|188492718\|ref\|ZP_02999988.1\| NAD(P) transhydrogenase, alpha subunit [Escherichia coli 53638], gi\|... gi\|169889102, gi... - gi\|170081267\|ref\|YP_001730587.1\| pyridine nucleotide transhydrogenase, alpha subunit [Escherichia co... EG10744 - pyridine nucleotide transhydrogenase, alpha subunit / Proton-translocating NAD(P) transhydrogenase, ...	1.0E-94	[6..366]	[3..356]
DHA_GEOSE - Alanine dehydrogenase OS=Geobacillus stearothermophilus GN=ald PE=1 SV=1	7.0E-94	[5..365]	[2..351]
DHA_BACSU - Alanine dehydrogenase OS=Bacillus subtilis GN=ald PE=3 SV=1 gi\|221324661 - gi\|221324661\|ref\|ZP_03605955.1\| L-alanine dehydrogenase [Bacillus subtilis subsp. subtilis str. SMY] DHA_BACSU - Alanine dehydrogenase OS=Bacillus subtilis (strain 168) GN=ald PE=1 SV=1 gi\|221320377 - gi\|221320377\|ref\|ZP_03601671.1\| L-alanine dehydrogenase [Bacillus subtilis subsp. subtilis str. JH64... gi\|221315461 - gi\|221315461\|ref\|ZP_03597266.1\| L-alanine dehydrogenase [Bacillus subtilis subsp. subtilis str. NCIB...	1.0E-93	[5..364]	[2..349]

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Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVTLHLRA ETKPLEARAA LTPTTVKKLI AKGFKIYVED SPQSTFNINE YRQAGAIIVP  60
   61 AGSWKTAPRD RIIIGLKEMP ETDTFPLVHE HIQFAHCYKD QAGWQNVLMR FIKGHGTLYD 120
  121 LEFLENDQGR RVAAF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [324-373]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLPREASEFF SHDLLPSLEL LPQRKTAPVW VRAKKLFDRH CARVKRSSRL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.69897
Match:	1pjbA_
Description:	L-alanine dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [136-323]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFYAGFAGAA LGVRDWAFKQ THSDDEDLPA VSPYPNEKAL VKDVTKDYKE ALATGARKPT  60
   61 VLIIGALGRC GSGAIDLLHK VGIPDANILK WDIKETSRGG PFDEIPQADI FINCIYLSKP 120
  121 IAPFTNMEKL NNPNRRLRTV VDVSADTTNP HNPIPIYTVA TVFNKPTVLV PTTAGPKLSV 180
  181 ISIDHLPS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.69897
Match:	1pjbA_
Description:	L-alanine dehydrogenase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits