Protein Overview: PPE1

General Information:
Name(s) found:	PPE1 / YHR075C [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein [SGD]
Organism:	Saccharomyces cerevisiae
Length:	400 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [IDA]
Biological Process:	sinus venosus formation [IDA] protein modification process [IGI] telomere maintenance [IMP]
Molecular Function:	carboxylesterase activity [IDA][IEA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDDLRRKIA LSQFERAKNV LDATFQEAYE DDENDGDALG SLPSFNGQSN RNRKYTGKTG  60
   61 STTDRISSKE KSSLPTWSDF FDNKELVSLP DRDLDVNTYY TLPTSLLSNT TSIPIFIFHH 120
  121 GAGSSGLSFA NLAKELNTKL EGRCGCFAFD ARGHAETKFK KADAPICFDR DSFIKDFVSL 180
  181 LNYWFKSKIS QEPLQKVSVI LIGHSLGGSI CTFAYPKLST ELQKKILGIT MLDIVEEAAI 240
  241 MALNKVEHFL QNTPNVFESI NDAVDWHVQH ALSRLRSSAE IAIPALFAPL KSGKVVRITN 300
  301 LKTFSPFWDT WFTDLSHSFV GLPVSKLLIL AGNENLDKEL IVGQMQGKYQ LVVFQDSGHF 360
  361 IQEDSPIKTA ITLIDFWKRN DSRNVVIKTN WGQHKTVQNT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		MRP1 MRP10 MRP13 MRP17 MRP2 MRP21 MRP4 MRP51 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS8 MRPS9 NAM9 PET123 PPE1 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 VAR1 YMR31
View Details	Ho Y, et al. (2002)		CDC55 GPG1 HEM15 HTA2 MKT1 PPE1 PPH21 PPH22 RPA135 RPB11 RPC40 RTS1 RTS3 RVB1 TAP42 TPD3
View Details	Qiu et al. (2008)		EHD3 MRP1 MRP10 MRP2 MRP21 MRP4 MRP51 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS9 NAM9 PET123 PPE1 RSM10 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM7 SWS2 VAR1 YDR124W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#31 Asynchronous Prep (Protease cleavage)	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YDR132C	PPE1	2	Unpublished Fields Lab Data
View Screen	MDM30	PPE1	2	Uetz P, et al. (2000)
View Screen	RGT2	PPE1	1	Unpublished Fields Lab Data
View Screen	SPO1	PPE1	1	Unpublished Fields Lab Data
View Screen	NAF1	PPE1	1	Hazbun TR, et al. (2003)
View Screen	YIF1	PPE1	1	Unpublished Fields Lab Data
View Screen	PEX15	PPE1	1	Unpublished Fields Lab Data
View Screen	IPL1	PPE1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..89]	deduced	N/A	No confident structure predictions are available.
2	View Details	[90..400]	PSI-BLAST	48.09691	Epoxide hydrolase, N-terminal domain; Mammalian epoxide hydrolase, C-terminal domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.81

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2