Protein Overview: THR1

General Information:
Name(s) found:	THR1 / YHR025W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321814\|ref\|NP_011890.1\| Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway; Thr1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S46772 homoserine kinase (EC 2.7.1.39) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|500690\|gb\|AAB68871.1\| Thr1p: Homoserine kinase [Saccharomyces cerevisiae] [NCBI NR] gi\|172978\|gb\|AAA35154.1\| homoserine kinase [Saccharomyces cerevisiae] [NCBI NR] gi\|125396\|sp\|P17423.4\|KHSE_YEAST RecName: Full=Homoserine kinase; Short=HSK; Short=HK [NCBI NR] Homoserine kinase OS=Saccharomyces cerevisiae GN=THR1 PE=1 SV=4 [Swiss-Prot] THR1 Homoserine kinase [mips] Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway [SGD] THR1, Chr VIII from 159429-160502 [yeast_orfs2] Chr VIII from 159429-160502 [yeastorf3.fasta] THR1 SGDID:S0001067, Chr VIII from 159430-160503, Verified ORF [yeastflysequest.fasta] Thr1p [Saccharomyces cerevisiae]gi\|500690\|gb\|AAB68871.1\| Thr1p: Homoserine kinase [Saccharomyces cerevisiae]gi\|630045\|pir\|\|S46772 homoserine kinase (EC 2.7.1.39) - yeast (Saccharomyces cerevisiae)gi\|125396\|sp\|P17423\|KHSE_YEAST Homoserine kinase (HK)gi [nrdb_11152004_Chlamydomonas] THR1 SGDID:S000001067, Chr VIII from 159431-160504, Verified ORF, "Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Homoserine kinase (HSK) (HK) [nr-271106-contam.fasta] Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway; Thr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Thr1p: Homoserine kinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] homoserine kinase [nr-271106-contam.fasta] [chemostatdb.fasta] Homoserine kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THR1 PE=1 SV=4 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] THR1 SGDID:S000001067, Chr VIII from 159438-160511, Genome Release 64-1-1, Verified ORF, "Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway" [yeast-030211-contam.fasta] THR1 SGDID:S000001067, Chr VIII from 159438-160511, Genome Release 64-2-1, Verified ORF, "Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway" [20141208_orf_trans.fasta] TR5926\|c0_g1_i1\|g.4121 ORF TR5926\|c0_g1_i1\|g.4121 TR5926\|c0_g1_i1\|m.4121 type:complete len:358 (+) TR5926\|c0_g1_i1:47-1120(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR2683\|c0_g1_i1\|g.1888 ORF TR2683\|c0_g1_i1\|g.1888 TR2683\|c0_g1_i1\|m.1888 type:complete len:358 (+) TR2683\|c0_g1_i1:47-1120(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YHR025W SGDID:S000001067, Chr VIII from 159438-160511, Genome Release 64-1-1, Verified ORF, "Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_7964\|g.5990 ORF asmbl_7964\|g.5990 asmbl_7964\|m.5990 type:complete len:358 (+) asmbl_7964:57-1130(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_8168\|g.4955 ORF ID=asmbl_8168\|g.4955 ID=asmbl_8168\|m.4955 type:complete len:358 (+) ID=asmbl_8168:57-1130(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_8245\|g.5008 ORF ID=asmbl_8245\|g.5008 ID=asmbl_8245\|m.5008 type:complete len:358 (+) ID=asmbl_8245:46-1119(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	357 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	isoleucine metabolic process [TAS] homoserine metabolic process [IDA] methionine metabolic process [TAS] threonine metabolic process [TAS]
Molecular Function:	homoserine kinase activity [IDA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRAFKIKVP ASSANIGPGY DVLGVGLSLF LELDVTIDSS QAQETNDDPN NCKLSYTKES  60
   61 EGYSTVPLRS DANLITRTAL YVLRCNNIRN FPSGTKVHVS NPIPLGRGLG SSGAAVVAGV 120
  121 ILGNEVAQLG FSKQRMLDYC LMIERHPDNI TAAMMGGFCG SFLRDLTPQE VERREIPLAE 180
  181 VLPEPSGGED TGLVPPLPPT DIGRHVKYQW NPAIKCIAII PQFELSTADS RGVLPKAYPT 240
  241 QDLVFNLQRL AVLTTALTMD PPNADLIYPA MQDRVHQPYR KTLIPGLTEI LSCVTPSTYP 300
  301 GLLGICLSGA GPTILALATE NFEEISQEII NRFAKNGIKC SWKLLEPAYD GASVEQQ

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ADE2 BSC2 CWH41 DBF4 DIG1 ECM29 HAL5 LAA1 MRC1 OPI9 PEX32 PRP5 PTH2 RGA2 RMA1 RPN3 SIR1 STE12 THR1 TLG2 VPS45 YDL199C YEL057C YPL035C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GPA1	THR1	1	Unpublished Fields Lab Data
View Screen	PAM18	THR1	1	Unpublished Fields Lab Data
View Screen	RED1	THR1	1	Unpublished Fields Lab Data
View Screen	YOR203W	THR1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	THR1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..210] [346..357]	PSI-BLAST	167.519517	Homoserine kinase
2	View Details	[211..345]	PSI-BLAST	167.519517	Homoserine kinase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
catalytic activity	0.836142537655721	bayes_pls_golite062009
structural constituent of ribosome	0.0246382239358082	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.59

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2