YRC Public Data Repository - Protein Structure Prediction

Protein:	THR1
Organism:	Saccharomyces cerevisiae
Length:	357 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THR1.

Description	E-value	Query Range	Subject Range
KHSE_YEAST - Homoserine kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THR1 PE=1 SV=4 THR1 - Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by...	4.0E-75	[1..357]	[1..357]
GAL1_CLOPE - Galactokinase OS=Clostridium perfringens GN=galK PE=3 SV=1 GAL1_CLOPE - Galactokinase OS=Clostridium perfringens (strain 13 / Type A) GN=galK PE=3 SV=1	2.0E-65	[8..350]	[23..383]
GAL1_FUSNN - Galactokinase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532... GAL1_FUSNN - Galactokinase OS=Fusobacterium nucleatum subsp. nucleatum GN=galK PE=3 SV=1	2.0E-64	[6..355]	[21..389]
GAL1_BACSU - Galactokinase OS=Bacillus subtilis (strain 168) GN=galK PE=3 SV=1 gi\|221316111 - gi\|221316111\|ref\|ZP_03597916.1\| galactokinase [Bacillus subtilis subsp. subtilis str. NCIB 3610] GAL1_BACSU - Galactokinase OS=Bacillus subtilis GN=galK PE=3 SV=1 gi\|221321023 - gi\|221321023\|ref\|ZP_03602317.1\| galactokinase [Bacillus subtilis subsp. subtilis str. JH642] gi\|221325307 - gi\|221325307\|ref\|ZP_03606601.1\| galactokinase [Bacillus subtilis subsp. subtilis str. SMY]	2.0E-64	[8..353]	[23..385]
gi\|208230 - gi\|208230\|gb\|AAA72509.1\| galK	1.0E-63	[6..352]	[22..379]
GAL1_ECO24 - Galactokinase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=galK PE=3 SV=1 gi\|75235774, gi\|... - gi\|75235774\|ref\|ZP_00719929.1\| COG0153: Galactokinase [Escherichia coli E110019], gi\|193069539\|ref\|Z... gi\|193065587, gi... - gi\|75256341\|ref\|ZP_00728011.1\| COG0153: Galactokinase [Escherichia coli E22], gi\|193065587\|ref\|ZP_03... gi\|595700 - gi\|595700\|gb\|AAA57082.1\| galactokinase [unidentified cloning vector] gi\|188493829, gi... - gi\|75511359\|ref\|ZP_00734044.1\| COG0153: Galactokinase [Escherichia coli 53638], gi\|188493829\|ref\|ZP_... gi\|58030, gi\|58033 - gi\|58033\|emb\|CAA47410.1\| galK gene from E.coli [synthetic construct], gi\|58030\|emb\|CAA47408.1\| galK ... GAL1_ECOLI - Galactokinase (EC 2.7.1.6) (Galactose kinase) - Escherichia coli GAL1_ECO57 - Galactokinase OS=Escherichia coli O157:H7 GN=galK PE=3 SV=2 GAL1_ECOBW - Galactokinase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=galK PE=3 SV=1 EG10363 - galactokinase / Galactokinase gi\|254160820, gi... - gi\|254160820\|ref\|YP_003043928.1\| galactokinase [Escherichia coli B str. REL606], gi\|253972721\|gb\|ACT... gi\|254591308, gi... - gi\|254791908\|ref\|YP_003076745.1\| galactokinase [Escherichia coli O157:H7 str. TW14359], gi\|254591308... gi\|194435024, gi... - gi\|83568959\|ref\|ZP_00920424.1\| COG0153: Galactokinase [Shigella dysenteriae 1012], gi\|194435024\|ref\|... gi\|194439764, gi... - gi\|83584858\|ref\|ZP_00923517.1\| COG0153: Galactokinase [Escherichia coli 101-1], gi\|194439764\|ref\|ZP_... EG10363 - galactokinase / Galactokinase gi\|89107608, gi\|... - gi\|89107608\|ref\|AP_001388.1\| galactokinase [Escherichia coli str. K-12 substr. W3110], gi\|1651342\|db... gi\|13360244, gi\|... - gi\|15830039\|ref\|NP_308812.1\| galactokinase [Escherichia coli O157:H7 str. Sakai], gi\|13360244\|dbj\|BA... gi\|86516626, gi\|... - gi\|86516638\|gb\|ABC98011.1\| GalK [Shigella boydii], gi\|86516634\|gb\|ABC98009.1\| GalK [Shigella boydii]... gi\|86516664 - gi\|86516664\|gb\|ABC98024.1\| GalK [Shigella dysenteriae] gi\|195936745 - gi\|195936745\|ref\|ZP_03082127.1\| galactokinase [Escherichia coli O157:H7 str. EC4024] gi\|168800811, gi... - gi\|189376968\|gb\|EDU95384.1\| galactokinase [Escherichia coli O157:H7 str. EC508], gi\|168800811\|ref\|ZP... gi\|208731433, gi... - gi\|208814785\|ref\|ZP_03255964.1\| galactokinase [Escherichia coli O157:H7 str. EC4045], gi\|208731433\|g... gi\|208727444, gi... - gi\|208807643\|ref\|ZP_03249980.1\| galactokinase [Escherichia coli O157:H7 str. EC4206], gi\|208727444\|g... GAL1_ECO5E - Galactokinase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=galK PE=3 SV=1 gi\|208737944, gi... - gi\|208822459\|ref\|ZP_03262778.1\| galactokinase [Escherichia coli O157:H7 str. EC4042], gi\|208737944\|g... GAL1_ECOLC - Galactokinase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=galK PE=3 SV=1 gi\|217321756, gi... - gi\|217325535\|ref\|ZP_03441619.1\| galactokinase [Escherichia coli O157:H7 str. TW14588], gi\|217321756\|... GAL1_ECOSE - Galactokinase OS=Escherichia coli (strain SE11) GN=galK PE=3 SV=1 gi\|188015487, gi... - gi\|188015487\|gb\|EDU53609.1\| galactokinase [Escherichia coli O157:H7 str. EC4113], gi\|168750249\|ref\|Z... gi\|168763347, gi... - gi\|189366430\|gb\|EDU84846.1\| galactokinase [Escherichia coli O157:H7 str. EC4501], gi\|168763347\|ref\|Z... gi\|189355897, gi... - gi\|189355897\|gb\|EDU74316.1\| galactokinase [Escherichia coli O157:H7 str. EC4401], gi\|168757046\|ref\|Z... gi\|187768179, gi... - gi\|187768179\|gb\|EDU32023.1\| galactokinase [Escherichia coli O157:H7 str. EC4196], gi\|168776498\|ref\|Z... gi\|189363413, gi... - gi\|189363413\|gb\|EDU81832.1\| galactokinase [Escherichia coli O157:H7 str. EC4486], gi\|168767202\|ref\|Z... gi\|189373137, gi... - gi\|189373137\|gb\|EDU91553.1\| galactokinase [Escherichia coli O157:H7 str. EC869], gi\|168786916\|ref\|ZP... gi\|189003027, gi... - gi\|189003027\|gb\|EDU72013.1\| galactokinase [Escherichia coli O157:H7 str. EC4076], gi\|168779245\|ref\|Z... gi\|124531874, gi... - gi\|124531874\|ref\|ZP_01701973.1\| galactokinase [Escherichia coli B], gi\|124498295\|gb\|EAY45813.1\| gala... GAL1_ECO55 - Galactokinase OS=Escherichia coli (strain 55989 / EAEC) GN=galK PE=3 SV=1 GAL1_ECO8A - Galactokinase OS=Escherichia coli O8 (strain IAI1) GN=galK PE=3 SV=1	2.0E-63	[6..352]	[22..379]
gi\|25287398 - gi\|25287398\|pir\|\|B85578 galactokinase [imported] - Escherichia coli (strain O157:H7, substrain EDL93... gi\|15800466, gi\|... - gi\|15800466\|ref\|NP_286478.1\| galactokinase [Escherichia coli O157:H7 EDL933], gi\|12513686\|gb\|AAG5508...	2.0E-63	[6..352]	[22..379]
gi\|60655365 - gi\|60655365\|gb\|AAX32246.1\| galactokinase 1 [synthetic construct] ENSPTRT00000017709 - null GALK1 - galactokinase 1 HGNC:4118\|MIM:60... - 1	4.0E-63	[7..354]	[32..389]
GAL1_SALDC - Galactokinase OS=Salmonella dublin (strain CT_02021853) GN=galK PE=3 SV=1 gi\|200391087, gi... - gi\|200391087\|ref\|ZP_03217698.1\| galactokinase [Salmonella enterica subsp. enterica serovar Virchow s... gi\|204930110, gi... - gi\|204930110\|ref\|ZP_03221131.1\| galactokinase [Salmonella enterica subsp. enterica serovar Javiana s... gi\|29142528, gi\|... - gi\|29142528\|ref\|NP_805870.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str. T... gi\|16759699 - gi\|16759699\|ref\|NP_455316.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str. C... GAL1_SALTI - Galactokinase OS=Salmonella typhi GN=galK PE=3 SV=1 GAL1_SALTI - Galactokinase OS=Salmonella typhi GN=galK PE=3 SV=1 gi\|238913334 - gi\|238913334\|ref\|ZP_04657171.1\| galactokinase [Salmonella enterica subsp. enterica serovar Tennessee... gi\|214001892 - gi\|214001892\|ref\|ZP_03412627.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... GAL1_SALEP - Galactokinase OS=Salmonella enteritidis PT4 (strain P125109) GN=galK PE=3 SV=1 gi\|213023145 - gi\|213023145\|ref\|ZP_03337592.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213427697 - gi\|213427697\|ref\|ZP_03360447.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213613330 - gi\|213613330\|ref\|ZP_03371156.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str...	6.0E-63	[6..352]	[22..379]

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Predicted Domain #1

Region A:
Residues: [1-210]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRAFKIKVP ASSANIGPGY DVLGVGLSLF LELDVTIDSS QAQETNDDPN NCKLSYTKES  60
   61 EGYSTVPLRS DANLITRTAL YVLRCNNIRN FPSGTKVHVS NPIPLGRGLG SSGAAVVAGV 120
  121 ILGNEVAQLG FSKQRMLDYC LMIERHPDNI TAAMMGGFCG SFLRDLTPQE VERREIPLAE 180
  181 VLPEPSGGED TGLVPPLPPT DIGRHVKYQW

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [346-357]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPAYDGASVE QQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	167.519517
Match:	1fwkA_
Description:	Homoserine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	0.836142537655721	bayes_pls_golite062009
structural constituent of ribosome	0.0246382239358082	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [211-345]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPAIKCIAII PQFELSTADS RGVLPKAYPT QDLVFNLQRL AVLTTALTMD PPNADLIYPA  60
   61 MQDRVHQPYR KTLIPGLTEI LSCVTPSTYP GLLGICLSGA GPTILALATE NFEEISQEII 120
  121 NRFAKNGIKC SWKLL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	167.519517
Match:	1fwkA_
Description:	Homoserine kinase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: