Protein Overview: PAM18

General Information:
Name(s) found:	PAM18 / YLR008C [SGD]
Description(s) found: Found 33 descriptions. SHOW ALL	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	168 amino acids
Gene Ontology:
Cellular Component:	mitochondrial inner membrane presequence translocase complex [IPI ] mitochondrion [IDA] presequence translocase-associated import motor [IPI ]
Biological Process:	protein import into mitochondrial matrix [IMP ][IPI ]
Molecular Function:	protein transporter activity [IMP][IPI] unfolded protein binding [ISS] ATPase activator activity [IDA ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQSNTGNS IEAPQLPIPG QTNGSANVTV DGAGVNVGIQ NGSQGQKTGM DLYFDQALNY  60
   61 MGEHPVITGF GAFLTLYFTA GAYKSISKGL NGGKSTTAFL KGGFDPKMNS KEALQILNLT 120
  121 ENTLTKKKLK EVHRKIMLAN HPDKGGSPFL ATKINEAKDF LEKRGISK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		MDJ2 MGE1 PAM16 PAM18 SSC1 TIM17 TIM22 TIM23 TIM44 TOM6 TOM7

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PAM18	RTT103	2	Unpublished Fields Lab Data
View Screen	PAM18	YCL056C	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..92]	deduced	N/A	No confident structure predictions are available.
2	View Details	[93..168]	PSI-BLAST	18.522879	HSP40

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.62

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2