Protein Overview: TIM22

General Information:
Name(s) found:	TIM22 / YDL217C [SGD]
Description(s) found: Found 34 descriptions. SHOW ALL	Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported [SGD]
Organism:	Saccharomyces cerevisiae
Length:	207 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial inner membrane protein insertion complex [IDA]
Biological Process:	protein import into mitochondrial inner membrane [IMP][IPI]
Molecular Function:	protein transporter activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVYTGFGLEQ ISPAQKKPYN ELTPEEQGER GAEMIMNFMT SCPGKSVVSG VTGFALGGVL  60
   61 GLFMASMAYD TPLHTPTPAN TAATATAGNI GVGGISRTVQ QISDLPFRQQ MKLQFTDMGK 120
  121 KSYSSAKNFG YIGMIYAGVE CVIESLRAKN DIYNGVTAGF FTGAGLAYKA GPQAALMGGA 180
  181 GFAAFSAAID LYMKSEDGRP PQNDFKE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		TIM10 TIM12 TIM22 TIM54 TIM9
View Details	Qiu et al. (2008)		OXA1 PAM18 TIM10 TIM12 TIM18 TIM22 TIM23 TIM44 TIM54 TOM40 TOM5 TOM70

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#12 Mitotic Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YJL147C	TIM22	2	Unpublished Fields Lab Data
View Screen	PML1	TIM22	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..207]	Pfam	117.79588	Tim17/Tim22/Tim23 family No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2