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Protein Overview: TIM12

General Information:
Name(s) found: TIM12 / YBR091C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 109 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial intermembrane space [TASLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane protein insertion complex [TASLink to PubMed article]
    Biological Process: protein import into mitochondrial inner membrane [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: protein transporter activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFLNSLRG NQEVSQEKLD VAGVQFDAMC STFNNILSTC LEKCIPHEGF GEPDLTKGEQ  60
   61 CCIDRCVAKM HYSNRLIGGF VQTRGFGPEN QLRHYSRFVA KEIADDSKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) TIM10 TIM12 TIM22 TIM54 TIM9
    View Details Qiu et al. (2008) TIM10 TIM12 TIM13 TIM18 TIM22 TIM54 TIM8 TIM9

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..109] Pfam 5.207608 Tim10/DDP family zinc finger No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  3.96569591038426 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  3.6132784640414 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  3.6132784640414 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  3.05578860381335 bayes_pls_golite062009
  • binding
    		•  3.05274001657604 bayes_pls_golite062009
  • transporter activity
    		•  2.98936530239986 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.87815769573142 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.67782980643723 bayes_pls_golite062009
  • protein binding
    		•  1.54231655177329 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.42890247609405 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.15847548838424 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.15316743403707 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.10003802565492 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle