YRC Public Data Repository - Protein Structure Prediction

Protein:	TIM12
Organism:	Saccharomyces cerevisiae
Length:	109 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIM12.

Description	E-value	Query Range	Subject Range
gi\|190408748 - gi\|190408748\|gb\|EDV12013.1\| mitochondrial regulator of splicing 5 [Saccharomyces cerevisiae RM11-1a] gi\|151946485 - gi\|151946485\|gb\|EDN64707.1\| protein of the inner mitochondrial membrane [Saccharomyces cerevisiae YJ... TIM12 - Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM2... TIM12_YEAST - Mitochondrial import inner membrane translocase subunit TIM12 OS=Saccharomyces cerevisiae (strain AT...	1.0E-39	[1..109]	[1..109]
gi\|5107178, gi\|7... - gi\|74096149\|ref\|NP_001027735.1\| small zinc finger-like protein [Ciona intestinalis], gi\|5107178\|gb\|A...	2.0E-24	[13..97]	[3..85]
TIM10_SCHPO - Mitochondrial import inner membrane translocase subunit tim10 OS=Schizosaccharomyces pombe (strain 9... tim10 - Tim9-Tim10 complex subunit Tim10	5.0E-24	[9..86]	[8..84]
gi\|109106266, gi... - gi\|109106268\|ref\|XP_001102305.1\| PREDICTED: similar to translocase of inner mitochondrial membrane 1... tr\|G1SF82\|G1SF82... - pep:novel chromosome:oryCun2:1:190612228:190615383:-1 gene:ENSOCUG00000001338 transcript:ENSOCUT0000... CCDS7959.1_1 - null TIM10_RAT - Mitochondrial import inner membrane translocase subunit Tim10 OS=Rattus norvegicus GN=Timm10 PE=3 SV... gi\|149758105 - gi\|149758105\|ref\|XP_001498316.1\| PREDICTED: similar to Mitochondrial import inner membrane transloca... TIMM10 - translocase of inner mitochondrial membrane 10 homolog (yeast) tr\|G3HRI3\|G3HRI3... - Mitochondrial import inner membrane translocase subunit Tim10 OS=Cricetulus griseus GN=I79_013455 PE... TIM10_MOUSE - Mitochondrial import inner membrane translocase subunit Tim10 OS=Mus musculus GN=Timm10 PE=1 SV=1 gi\|55635935, gi\|... - gi\|55635935\|ref\|XP_508433.1\| PREDICTED: translocase of inner mitochondrial membrane 10 homolog isofo... ENSCJAT00000017183 - null	2.0E-23	[13..97]	[3..85]
gi\|7305575, gi\|5... - gi\|7305575\|ref\|NP_038927.1\| translocase of inner mitochondrial membrane 13 homolog a [Mus musculus],...	4.0E-23	[13..97]	[3..85]
gi\|5107172 - gi\|5107172\|gb\|AAD39998.1\|AF150092_1 small zinc finger-like protein [Drosophila melanogaster]	4.0E-23	[13..96]	[8..91]
tin-10 - status:Confirmed UniProt:Q9Y0V6 protein_id:CAC70139.1	1.0E-22	[14..97]	[3..85]
TIM10_PICSO - Mitochondrial import inner membrane translocase subunit Tim10 OS=Pichia sorbitophila (strain ATCC MY... TIM10_MILFA, TIM... - Mitochondrial import inner membrane translocase subunit Tim10 OS=Pichia farinosa GN=TIM10 PE=3 SV=1,...	2.0E-22	[12..86]	[9..82]
TIM10_ARATH - Mitochondrial import inner membrane translocase subunit TIM10 OS=Arabidopsis thaliana GN=TIM10 PE=1 ...	1.0E-20	[14..83]	[10..78]

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Predicted Domain #1

Region A:
Residues: [1-109]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFLNSLRG NQEVSQEKLD VAGVQFDAMC STFNNILSTC LEKCIPHEGF GEPDLTKGEQ  60
   61 CCIDRCVAKM HYSNRLIGGF VQTRGFGPEN QLRHYSRFVA KEIADDSKK

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	5.207608
Match:	PF02953
Description:	Tim10/DDP family zinc finger

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
protein transporter activity	3.96569591038426	bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity	3.6132784640414	bayes_pls_golite062009
macromolecule transmembrane transporter activity	3.6132784640414	bayes_pls_golite062009
protein transmembrane transporter activity	3.05578860381335	bayes_pls_golite062009
binding	3.05274001657604	bayes_pls_golite062009
transporter activity	2.98936530239986	bayes_pls_golite062009
substrate-specific transporter activity	2.87815769573142	bayes_pls_golite062009
transmembrane transporter activity	1.67782980643723	bayes_pls_golite062009
protein binding	1.54231655177329	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.42890247609405	bayes_pls_golite062009
primary active transmembrane transporter activity	1.15847548838424	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.15316743403707	bayes_pls_golite062009
active transmembrane transporter activity	1.10003802565492	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: