Protein Overview: MIP6

General Information:
Name(s) found:	MIP6 / YHR015W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731637\|sp\|P38760.1\|MIP6_YEAST RecName: Full=RNA-binding protein MIP6; AltName: Full=MEX67-interacting protein 6 [NCBI NR] gi\|6321803\|ref\|NP_011879.1\| Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; Mip6p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S46788 PES4 protein homolog YHR015w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|500707\|gb\|AAB68942.1\| Yhr015wp [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized RNA-binding protein YHR015W OS=Saccharomyces cerevisiae GN=YHR015W PE=1 SV=1 [Swiss-Prot] RNA-binding protein MIP6 OS=Saccharomyces cerevisiae GN=MIP6 PE=1 SV=1 [Swiss-Prot] MIP6 RNA(PolyA)-binding protein, interacts with MEX67 [mips] Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export [SGD] MIP6, Chr VIII from 134545-136524 [yeast_orfs2] Chr VIII from 134545-136524 [yeastorf3.fasta] (P38760) Hypothetical 75.9 kDa protein in SPO13-ARG4 intergenic region [4932.FASTACCERV.txt] MIP6 SGDID:S0001057, Chr VIII from 134546-136525, Verified ORF [yeastflysequest.fasta] Mip6p [Saccharomyces cerevisiae]gi\|731637\|sp\|P38760\|YHH5_YEAST Hypothetical 75.9 kDa protein in SPO13-ARG4 intergenic regiongi\|626773\|pir\|\|S46788 PES4 protein homolog YHR015w - yeast (Saccharomyces cerevisiae)gi\|500707\|gb\|AAB68942.1\| Yhr015wp [Saccharo [nrdb_11152004_Chlamydomonas] MIP6 SGDID:S000001057, Chr VIII from 134547-136526, Verified ORF, "Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Probable RNA-binding protein YHR015W [nr-271106-contam.fasta] Yhr015wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; Mip6p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] RNA-binding protein MIP6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MIP6 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MIP6 SGDID:S000001057, Chr VIII from 134554-136533, Genome Release 64-1-1, Verified ORF, "Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export" [yeast-030211-contam.fasta] MIP6 SGDID:S000001057, Chr VIII from 134554-136533, Genome Release 64-2-1, Verified ORF, "Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YHR015W SGDID:S000001057, Chr VIII from 134554-136533, Genome Release 64-1-1, Verified ORF, "Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	659 amino acids
Gene Ontology:
Cellular Component:	nuclear pore [IPI]
Biological Process:	mRNA export from nucleus [IPI]
Molecular Function:	RNA binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNSHGNVLN NISLNSKQNP RSISKSCPND KDARQKSFKT ISAQALVRVQ GAGYKLGDVK  60
   61 LKDAEVKEKN SLKKYDCKNA TQEKKEQEQV FEKTVAKGSV QKYITKTSKT NSLFIGNLKS 120
  121 TVTEEMLRKI FKRYQSFESA KVCRDFLTKK SLGYGYLNFK DKNDAESARK EFNYTVFFGQ 180
  181 EVKIMPSMKN TLFRKNIGTN VFFSNLPLEN PQLTTRSFYL IMIEYGNVLS CLLERRKNIG 240
  241 FVYFDNDISA RNVIKKYNNQ EFFGNKIICG LHFDKEVRTR PEFTKRKKMI GSDIVIEDEL 300
  301 LASNNLSDNA RSKTILVKNL PSDTTQEEVL DYFSTIGPIK SVFISEKQAN TPHKAFVTYK 360
  361 NEEESKKAQK CLNKTIFKNH TIWVGPGKDK PVHNQIGTNK KTKVYLKNLS FNCNKEFISQ 420
  421 LCLQEKIRFS EIKITNYNSL NWTFCGHVEC FSRSDAERLF NILDRRLIGS SLVEASWSKN 480
  481 NDNILNEIDY DDGNNNENYK KLINISSMMR FRTQELSAHQ KGLTSQFQQV VSPFSSYSNS 540
  541 YTNMNSLVAT PMKPHPAFNL ITNTVDEKLH QPKRTKQENA EILESLKKII NRNLQRISIS 600
  601 GLNKEENLRS ISEFIFDVFW EHDSERLSHF LLMTNTSLES QKILQKQVTR AAESLGFTV

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Gavin AC, et al. (2002)		CLU1 CRN1 ECM29 KAP123 MEC1 MIP6 MIS1 MRPL23 NAB3 NAB6 NRD1 ROM2 RPA135 SEN54 SUI3 SUP35 SUP45 TAO3 USO1 UTP20 VAC14 VPS5 YJL017W
View Details	Qiu et al. (2008)		KAP122 MIP6 MLP1 SUS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#34 Asynchronous SPB prep	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	MIP6	Huh WK, et al. (2003)

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
RNA binding	4.43921816934576	bayes_pls_golite062009
binding	3.49612884560266	bayes_pls_golite062009
mRNA binding	3.1794312979994	bayes_pls_golite062009
nucleocytoplasmic transporter activity	2.51546867995401	bayes_pls_golite062009
nucleic acid binding	2.34356093608328	bayes_pls_golite062009
protein binding	1.32954276279597	bayes_pls_golite062009
transporter activity	1.15189574940599	bayes_pls_golite062009
transmembrane transporter activity	1.06701715708589	bayes_pls_golite062009
single-stranded RNA binding	0.851308060174055	bayes_pls_golite062009
substrate-specific transporter activity	0.796360682730618	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.540791176419082	bayes_pls_golite062009
mRNA 3'-UTR binding	0.414871108842203	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity	0.212405663170905	bayes_pls_golite062009
poly-purine tract binding	0.15653271757169	bayes_pls_golite062009
poly-pyrimidine tract binding	0.11509546367801	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.096231856558874	bayes_pls_golite062009
pyrophosphatase activity	0.059732432409948	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0510390778764699	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0484248928275733	bayes_pls_golite062009
poly(A) RNA binding	0.0459878286238641	bayes_pls_golite062009

Term	Confidence	Notes
RNA binding	4.43921816934576	bayes_pls_golite062009
binding	3.49612884560266	bayes_pls_golite062009
mRNA binding	3.1794312979994	bayes_pls_golite062009
nucleocytoplasmic transporter activity	2.51546867995401	bayes_pls_golite062009
nucleic acid binding	2.34356093608328	bayes_pls_golite062009
protein binding	1.32954276279597	bayes_pls_golite062009
transporter activity	1.15189574940599	bayes_pls_golite062009
transmembrane transporter activity	1.06701715708589	bayes_pls_golite062009
single-stranded RNA binding	0.851308060174055	bayes_pls_golite062009
substrate-specific transporter activity	0.796360682730618	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.540791176419082	bayes_pls_golite062009
mRNA 3'-UTR binding	0.414871108842203	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity	0.212405663170905	bayes_pls_golite062009
poly-purine tract binding	0.15653271757169	bayes_pls_golite062009
poly-pyrimidine tract binding	0.11509546367801	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.096231856558874	bayes_pls_golite062009
pyrophosphatase activity	0.059732432409948	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0510390778764699	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0484248928275733	bayes_pls_golite062009
poly(A) RNA binding	0.0459878286238641	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..96]	deduced	N/A	No confident structure predictions are available.
2	View Details	[97..189]	PSI-BLAST	262.533179	Poly(A)-binding protein
3	View Details	[190..294]	PSI-BLAST	262.533179	Poly(A)-binding protein
4	View Details	[295..389]	PSI-BLAST	85.056057	Sex-lethal protein
5	View Details	[390..543]	PSI-BLAST	85.056057	Sex-lethal protein
6	View Details	[544..659]	deduced	N/A	No confident structure predictions are available.

Protein Overview: MIP6

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: