Protein Overview: NUP57

General Information:
Name(s) found:	NUP57 / YGR119C [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	541 amino acids
Gene Ontology:
Cellular Component:	nuclear pore [IDA]
Biological Process:	mRNA export from nucleus [IMP] rRNA export from nucleus [TAS] nuclear pore organization [TAS] snRNP protein import into nucleus [TAS] mRNA-binding (hnRNP) protein import into nucleus [TAS] snRNA export from nucleus [TAS] protein import into nucleus [IMP] tRNA export from nucleus [TAS] NLS-bearing substrate import into nucleus [TAS] protein export from nucleus [TAS] ribosomal protein import into nucleus [TAS]
Molecular Function:	structural molecule activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFGFSGSNNG FGNKPAGSTG FSFGQNNNNT NTQPSASGFG FGGSQPNSGT ATTGGFGANQ  60
   61 ATNTFGSNQQ SSTGGGLFGN KPALGSLGSS STTASGTTAT GTGLFGQQTA QPQQSTIGGG 120
  121 LFGNKPTTTT GGLFGNSAQN NSTTSGGLFG NKVGSTGSLM GGNSTQNTSN MNAGGLFGAK 180
  181 PQNTTATTGG LFGSKPQGST TNGGLFGSGT QNNNTLGGGG LFGQSQQPQT NTAPGLGNTV 240
  241 STQPSFAWSK PSTGSNLQQQ QQQQIQVPLQ QTQAIAQQQQ LSNYPQQIQE QVLKCKESWD 300
  301 PNTTKTKLRA FVYNKVNETE AILYTKPGHV LQEEWDQAME KKPSPQTIPI QIYGFEGLNQ 360
  361 RNQVQTENVA QARIILNHIL EKSTQLQQKH ELDTASRILK AQSRNVEIEK RILKLGTQLA 420
  421 TLKNRGLPLG IAEEKMWSQF QTLLQRSEDP AGLGKTNELW ARLAILKERA KNISSQLDSK 480
  481 LMVFNDDTKN QDSMSKGTGE ESNDRINKIV EILTNQQRGI TYLNEVLEKD AAIVKKYKNK 540
  541 T

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		NIC96 NUP49 NUP57
View Details	(MIPS) Mewes HW, et al. (2004)		NIC96 NSP1 NUP49 NUP57
View Details	Krogan NJ, et al. (2006)		NIC96 NUP49 NUP57
View Details	Qiu et al. (2008)		GLE2 MEX67 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 NUP49 NUP53 NUP57 NUP82 NUP84 POM152 SEC13 SEH1 SUS1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RPC19	NUP57	2	Unpublished Fields Lab Data
View Screen	THP2	NUP57	2	Unpublished Fields Lab Data
View Screen	APC2	NUP57	2	Unpublished Fields Lab Data
View Screen	PSE1	NUP57	2	Uetz P, et al. (2000)

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	NUP57	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..287]	ORFEUS	14.2	No description for 1ldvA was found.
2	View Details	[288..427]	PSI-BLAST	5.221849	Annexin VI
3	View Details	[428..541]	deduced	N/A	Confident ab initio structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2