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Protein Overview: PHO4

General Information:
Name(s) found: PHO4 / YFR034C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 312 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: cellular response to phosphate starvation [IDALink to PubMed article][IMPLink to PubMed article]
    phosphate metabolic process [TASLink to PubMed article]
    Molecular Function: transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRTTSEGIH GFVDDLEPKS SILDKVGDFI TVNTKRHDGR EDFNEQNDEL NSQENHNSSE  60
   61 NGNENENEQD SLALDDLDRA FELVEGMDMD WMMPSHAHHS PATTATIKPR LLYSPLIHTQ 120
  121 SAVPVTISPN LVATATSTTS ANKVTKNKSN SSPYLNKRRG KPGPDSATSL FELPDSVIPT 180
  181 PKPKPKPKQY PKVILPSNST RRVSPVTAKT SSSAEGVVVA SESPVIAPHG SSHSRSLSKR 240
  241 RSSGALVDDD KRESHKHAEQ ARRNRLAVAL HELASLIPAE WKQQNVSAAP SKATTVEAAC 300
  301 RYIRHLQQNV ST

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GLN4 PBI2 PHO4 PRB1 SOD2 YNL019C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PHO4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..247] deduced N/A No confident structure predictions are available.
    2 View Details [248..312] PSI-BLAST 273.68867 Pho4 B/HLH domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  4.94162117310222 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.64041369991064 bayes_pls_golite062009
  • transcription factor activity
    		•  4.57572673546692 bayes_pls_golite062009
  • binding
    		•  4.34145697128117 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • transcription activator activity
    		•  2.5495467409976 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.48787404513864 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.23044824326772 bayes_pls_golite062009
  • protein binding
    		•  1.65995700436208 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  1.43264235539529 bayes_pls_golite062009
  • sterol response element binding
    		•  1.35908389783271 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.05787100777909 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.82134057325852 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.672485914465871 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle