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View Structure Prediction Details

Protein: PHO4
Organism: Saccharomyces cerevisiae
Length: 312 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHO4.

Description E-value Query
Range
Subject
Range
gi|4157 - gi|4157|emb|CAA36810.1| unnamed protein product [Saccharomyces cerevisiae]
0.0 [1..312] [1..312]

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Predicted Domain #1
Region A:
Residues: [1-247]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRTTSEGIH GFVDDLEPKS SILDKVGDFI TVNTKRHDGR EDFNEQNDEL NSQENHNSSE  60
   61 NGNENENEQD SLALDDLDRA FELVEGMDMD WMMPSHAHHS PATTATIKPR LLYSPLIHTQ 120
  121 SAVPVTISPN LVATATSTTS ANKVTKNKSN SSPYLNKRRG KPGPDSATSL FELPDSVIPT 180
  181 PKPKPKPKQY PKVILPSNST RRVSPVTAKT SSSAEGVVVA SESPVIAPHG SSHSRSLSKR 240
  241 RSSGALV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [248-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDDKRESHKH AEQARRNRLA VALHELASLI PAEWKQQNVS AAPSKATTVE AACRYIRHLQ  60
   61 QNVST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 273.68867
Match: 1a0aA_
Description: Pho4 B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 4.94162117310222 bayes_pls_golite062009
nucleic acid binding 4.64041369991064 bayes_pls_golite062009
transcription factor activity 4.57572673546692 bayes_pls_golite062009
binding 4.34145697128117 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
sequence-specific DNA binding 2.23044824326772 bayes_pls_golite062009
protein binding 1.65995700436208 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 1.43264235539529 bayes_pls_golite062009
sterol response element binding 1.35908389783271 bayes_pls_golite062009
structure-specific DNA binding 1.05787100777909 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
double-stranded DNA binding 0.82134057325852 bayes_pls_golite062009
transcription corepressor activity 0.672485914465871 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle