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Protein Overview: SSN2

General Information:
Name(s) found: SSN2 / YDR443C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1420 amino acids

    Gene Ontology:
    Cellular Component: transcription factor complex [TASLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [TASLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDASTYRL EDVLSSFYRV EKIKKINYHQ YISKAQNDQW SIQMEFMLRK QDPKTLVALL  60
   61 SRDLWCFSIN DDPVPTPPAI EHKPVSPDKI GTFTADYSKP NLPPHYALFL KALRRKIYIN 120
  121 LALGSHNKLI QFGNACISLS GVPNYLVQLE PHLFVNGDLT VSLCAKNMGL VPMKEENLEE 180
  181 SFLSKHALYL APSGIRMHLA PASKQGYLIT PPKHTELLLT TLSVSHGINL QNKKNLKWVA 240
  241 VVPDLGHLNG HTPTIASYLT PLLEAKKLVW PLHLIFAQPV ADIENSTSGD PSEFHCLQDA 300
  301 LDAIDDFIQL KQTAAYRTPG SSGVLSSNIA GTNPLSSDGA YTEQFQHYKN NSISSQPASY 360
  361 HSVQETNKIS PKDFSPNFTG IDKLMLSPSD QFAPAFLNTP NNNINENELF NDRKQTTVSN 420
  421 DLENSPLKTE LEANGRSLEK VNNSVSKTGS VDTLHNKEGT LEQREQNENL PSDKSDSMVD 480
  481 KELFGEDEDE DLFGDSNKSN STNESNKSIS DEITEDMFEM SDEEENNNNK SINKNNKEMH 540
  541 TDLGKDIPFF PSSEKPNIRT MSGTTKRLNG KRKYLDIPID EMTLPTSPLY MDPGAPLPVE 600
  601 TPRDRRKSVF APLNFNPIIE NNVDNKYKSG GKFSFSPLQK EEALNFDISM ADLSSSEEEE 660
  661 DEEENGSSDE DLKSLNVRDD MKPSDNISTN TNIHEPQYIN YSSIPSLQDS IIKQENFNSV 720
  721 NDANITSNKE GFNSIWKIPQ NDIPQTESPL KTVDSSIQPI ESNIKMTLED NNVTSNPSEF 780
  781 TPNMVNSEIS NLPKDKSGIP EFTPADPNLS FESSSSLPFL LRHMPLASIP DIFITPTPVV 840
  841 TISEKEQDIL DLIAEQVVTD YNILGNLGIP KIAYRGVKDC QEGLITTTML QLFSTFDRLN 900
  901 GNDTISKFYN MKQPYVFVKK HHELIKVKHD SQPFIKFLNF RPPNGIKNFK SLLLSSSFKE 960
  961 DCLSFAPTLS QTYINQELGF CELLKLTNED PPGLMYLKAF DKNKLLLLAA QIVSYCSNNK1020
 1021 NSIKNVPPIL IILPLDNATL TELVDKANIF QVIKNEVCAK MPNIELYLKV IPMDFIRNVL1080
 1081 VTVDQYVNVA ISIYNMLPPK SVKFTHIAHT LPEKVNFRTM QQQQMQQQQQ QQQQQQNNST1140
 1141 GSSSIIYYDS YIHLAYSRSV DKEWVFAALS DSYGQGSMTK TWYVGNSRGK FDDACNQIWN1200
 1201 IALNLASKKF GKICLILTRL NGILPDDELM NWRRLSGRNI HLAVVCVDDN SKISFIDEDK1260
 1261 LYPSFKPIYK DTRFGGRMDM TRLYDYEIRD IDQDIHGIVF QHPFPLAHSQ HRCAIRSGAL1320
 1321 IKFKKCDGDT VWDKFAVNLL NCPHSDSTQL LETILEEFRN LAALNVWYGL SDGEDGHIPW1380
 1381 HILAVKKMMN TLVHTRVKIA NTSAATVHTA TSSSIILSDK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ADA2 CSE2 GAL11 MED1 MED11 MED4 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SSN2 SSN3 YAP1
    View Details (MIPS) Mewes HW, et al. (2004) SRB8 SSN2 SSN3 SSN8
    View Details Krogan NJ, et al. (2006) HTD2 SRB8 SSN2
    View Details Gavin AC, et al. (2006) CSE2 GAL11 MED1 MED11 MED6 MED7 MED8 NUT1 NUT2 PGD1 RGR1 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SSN2
    View Details Gavin AC, et al. (2002) ADA2 ADH1 COG3 CSE2 ENO2 FAB1 FBA1 GAL11 GCN5 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MLP1 MRPL6 NUT1 NUT2 PGD1 PGK1 RGR1 ROX3 RPG1 RPO21 SIN4 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSE2 SSN2 SSN3 SSN8 TAF6 TIF1, TIF2 YIL077C
    View Details Qiu et al. (2008) POP2 SIN4 SSN2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SSN2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1420] deduced N/A No confident structure predictions are available.
    2 View Details [279..681] FFAS03 1.01 30S subunit
    3 View Details [682..791] deduced N/A No confident structure predictions are available.
    4 View Details [792..1026] deduced N/A No confident structure predictions are available.
    5 View Details [1027..1249] deduced N/A No confident structure predictions are available.
    6 View Details [1250..1420] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle