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Protein Overview: MSS4

General Information:
Name(s) found: MSS4 / YDR208W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 779 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: ascospore formation [IGILink to PubMed article][IMPLink to PubMed article]
    actin cytoskeleton organization [IMPLink to PubMed article]
    Molecular Function: 1-phosphatidylinositol-4-phosphate 5-kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVLRSQPPS VVPLHLTTST SRKTEQEPSL LHSAIIERHQ DRSVPNSNSN PDSNHRIKKD  60
   61 RNNHTSYHSS SNSESNMESP RLSDGESSTP TSIEELNPTI NNSRLVKRNY SISIDPLHDN 120
  121 SNNNTDDDHP NTITSPRPNS TSNKEMQKYS FPEGKESKKI TTPSLNSNNC LDLDNSSLVH 180
  181 TDSYIQDLND DHILLNKRVS RRSSRISAVT ATSTTIKQRR NTQDSNLPNI PFHASKHSQI 240
  241 LPMDDSDVIK LANGDTSMKP NSATKISHSM TSLPLHPLPQ PSQKSKQYHM ISKSTTSLPP 300
  301 ENDHYYQHSR GTNHNHAANA AAVNNNTTTT TAATGLKRSE SATAEIKKMR QSLLHKREMK 360
  361 RKRKTFLVDD DRVLIGNKVS EGHVNFIIAY NMLTGIRVAV SRCSGIMKPL TPADFRFTKK 420
  421 LAFDYHGNEL TPSSQYAFKF KDYCPEVFRE LRALFGLDPA DYLVSLTSKY ILSELNSPGK 480
  481 SGSFFYYSRD YKYIIKTIHH SEHIHLRKHI QEYYNHVRDN PNTLICQFYG LHRVKMPISF 540
  541 QNKIKHRKIY FLVMNNLFPP HLDIHITYDL KGSTWGRFTN LDKERLAKDR SYRPVMKDLN 600
  601 WLEEGQKIKF GPLKKKTFLT QLKKDVELLA KLNTMDYSLL IGIHDINKAK EDDLQLADTA 660
  661 SIEEQPQTQG PIRTGTGTVV RHFFREFEGG IRASDQFNND VDLIYYVGII DFLTNYSVMK 720
  721 KLETFWRSLR HDTKLVSAIP PRDYANRFYE FIEDSVDPLP QKKTQSSYRD DPNQKNYKD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
    View Details Qiu et al. (2008) MSS4 TOR2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD51 MSS4 1 Unpublished Fields Lab Data
    View Screen HMT1 MSS4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..299] deduced N/A No confident structure predictions are available.
    2 View Details [300..556] PSI-BLAST 481.228787 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
    3 View Details [557..779] PSI-BLAST 481.228787 Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • inositol or phosphatidylinositol kinase activity
    		•  4.31726963575315 bayes_pls_golite062009
  • lipid kinase activity
    		•  3.63026201392483 bayes_pls_golite062009
  • phosphatidylinositol phosphate kinase activity
    		•  3.5005619620026 bayes_pls_golite062009
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity
    		•  3.00599233846946 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.8512866333787 bayes_pls_golite062009
  • kinase activity
    		•  2.68971389233526 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.48646215276903 bayes_pls_golite062009
  • catalytic activity
    		•  1.87792712964225 bayes_pls_golite062009
  • binding
    		•  1.66593042987179 bayes_pls_golite062009
  • transferase activity
    		•  1.20817067352467 bayes_pls_golite062009
  • signal transducer activity
    		•  1.15068527302487 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.15068527302487 bayes_pls_golite062009
  • protein kinase activity
    		•  0.709372924978886 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.489382280175196 bayes_pls_golite062009
  • ligase activity
    		•  0.435608917599349 bayes_pls_golite062009
  • protein binding
    		•  0.382966234080422 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.189737258618863 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle