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Protein Overview: SPC19

General Information:
Name(s) found: SPC19 / YDR201W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 165 amino acids

    Gene Ontology:
    Cellular Component: spindle microtubule [IDALink to PubMed article]
    DASH complex [IDALink to PubMed articleLink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed articleLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    spindle [IDALink to PubMed article]
    condensed nuclear chromosome kinetochore [IDALink to PubMed articleLink to PubMed article]
    Biological Process: microtubule nucleation [IPILink to PubMed article]
    mitotic spindle organization in nucleus [IPILink to PubMed article]
    regulation of microtubule polymerization or depolymerization [IDALink to PubMed article][IPILink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDALEQSVL ALEGTVSVLK DSVESLKCAN EPSTNLASTM LQTKRVFRLV PEYDVERSKL  60
   61 DLIEEVEPLV RTLGDKLRKS MGRMQRELDT LQQTYELNDL RLKKNISMDD DDALNSPDMG 120
  121 QEYEGRDADD VVMMASSTNE ELEELKKLKE KKKQLENKLE ILKQK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ASK1 DAD1 DAD2 DAD3 DAM1 DUO1 HSK3 SPC19 SPC34
    View Details (MIPS) Mewes HW, et al. (2004) AME1 ARP1 ASK1 BIK1 CIK1 DAD1 DAD2 DAD3 DAD4 DAM1 DUO1 DYN1 JNM1 KAR3 KAR5 NUF2 SPC19 SPC34 STU1 STU2 TID3
    View Details Krogan NJ, et al. (2006) ASK1 DAD1 DAD4 DAM1 DUO1 HSK3 NCA2 SPC19 SPC34
    View Details Qiu et al. (2008) ARP1 ARP10 ASK1 BBP1 BIK1 BIM1 CDC31 CIK1 CNM67 DAD1 DAD2 DAD3 DAD4 DAM1 DUO1 HSK3 KAR3 MHP1 MPS2 NUF2 OKP1 SFI1 SPC105 SPC110 SPC19 SPC24 SPC25 SPC29 SPC34 SPC42 SPC97 SPC98 STU1 STU2 TID3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 No Comments Cheeseman IM, et al. (2002)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SPC19 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle