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Protein Overview: GPD1

General Information:
Name(s) found: GPD1 / YDL022W [SGD]
Description(s) found:
Found 37 descriptions.
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  • NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 391 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: NADH oxidation [IMPLink to PubMed article]
    intracellular accumulation of glycerol [IMPLink to PubMed article]
    Molecular Function: glycerol-3-phosphate dehydrogenase (NAD+) activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAADRLNL TSGHLNAGRK RSSSSVSLKA AEKPFKVTVI GSGNWGTTIA KVVAENCKGY  60
   61 PEVFAPIVQM WVFEEEINGE KLTEIINTRH QNVKYLPGIT LPDNLVANPD LIDSVKDVDI 120
  121 IVFNIPHQFL PRICSQLKGH VDSHVRAISC LKGFEVGAKG VQLLSSYITE ELGIQCGALS 180
  181 GANIATEVAQ EHWSETTVAY HIPKDFRGEG KDVDHKVLKA LFHRPYFHVS VIEDVAGISI 240
  241 CGALKNVVAL GCGFVEGLGW GNNASAAIQR VGLGEIIRFG QMFFPESREE TYYQESAGVA 300
  301 DLITTCAGGR NVKVARLMAT SGKDAWECEK ELLNGQSAQG LITCKEVHEW LETCGSVEDF 360
  361 PLFEAVYQIV YNNYPMKNLP DMIEELDLHE D

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GPD1 PDR5 PHO86 PMA1 PMT1 SSH1 WBP1 YGR266W
    View Details Ho Y, et al. (2002) CAR2 DMA2 DUN1 FAR1 GPD1 GPD2 LSP1 MDM30 PDC6 PIL1 RAD1 SAW1 SEC6 SEN1 STE20 UBI4 YHR033W
    View Details Qiu et al. (2008) ADH1 GPD1 GPD2 PNC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GPD1 and PEX3 Huh WK, et al. (2003)
    View Data GPD1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..240]
    [285..298]    		 PSI-BLAST 208.491979 Glycerol-3-phosphate dehydrogenase; Glycerol-3- phosphate dehydrogenase
    2 View Details [241..284]
    [299..391]    		 PSI-BLAST 208.491979 Glycerol-3-phosphate dehydrogenase; Glycerol-3- phosphate dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle