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Protein Overview: DUG2

General Information:
Name(s) found: DUG2 / YBR281C [SGD]
Description(s) found:
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  • gi|6319758|ref|NP_009840.1| Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (E [NCBI NR]
  • pir||S44543 hypothetical protein YBR281c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|586394|sp|P38149.1|YB9X_YEAST RecName: Full=WD repeat-containing protein YBR281C [NCBI NR]
  • gi|536726|emb|CAA85245.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|429126|emb|CAA53644.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1587539|prf||2206494G ORF YBR2018 [NCBI NR]
  • WD repeat-containing protein YBR281C OS=Saccharomyces cerevisiae GN=YBR281C PE=1 SV=1 [Swiss-Prot]
  • Probable di- and tripeptidase DUG2 OS=Saccharomyces cerevisiae GN=DUG2 PE=1 SV=1 [Swiss-Prot]
  • Protein of unknown function localised to cytoplasm and nucleus [mips]
  • Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) [SGD]
  • YBR281C, Chr II from 764927-767563, reverse complement [yeast_orfs2]
  • Chr II from 764927-767563, reverse complement [yeastorf3.fasta]
  • Chr II from 764926-767562, reverse complement [yeastorf4.fasta]
  • Chr II from 767560-764924, reverse complement [yeastorf5.fasta]
  • (P38149) Hypothetical 98.1 kDa Trp-Asp repeats containing protein in PAF1-MRPL27 intergenic region [4932.FASTACCERV.txt]
  • YBR281C SGDID:S0000485, Chr II from 767564-764928, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • YBR281C SGDID:S0000485, Chr II from 767602-764966, reverse complement, Uncharacterized ORF [10112005cervSGD.fasta]
  • Ybr281cp [Saccharomyces cerevisiae]gi|429126|emb|CAA53644.1| unnamed protein product [Saccharomyces cerevisiae]gi|536726|emb|CAA85245.1| unnamed protein product [Saccharomyces cerevisiae]gi|586394|sp|P38149|YB9X_YEAST Hypothetical 98.1 kDa Trp-Asp repe [nrdb_11152004_Chlamydomonas]
  • YBR281C SGDID:S000000485, Chr II from 767602-764966, reverse complement, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YBR281C SGDID:S000000485, Chr II from 767602-764966, reverse complement, Uncharacterized ORF, "Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR281C is not an essential gene" [yeast-contam.fasta]
  • DUG2 SGDID:S000000485, Chr II from 767602-764966, reverse complement, Verified ORF, "Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathw [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • ORF YBR2018 [nr-271106-contam.fasta]
  • WD repeat protein YBR281C [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR281C is not an essential gene; Ybr281cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • DUG2 SGDID:S000000485, Chr II from 767602-764966, reverse complement, Verified ORF, "Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Probable di- and tripeptidase DUG2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUG2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • DUG2 SGDID:S000000485, Chr II from 767606-764970, Genome Release 64-1-1, reverse complement, Verified ORF, "Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" [yeast-030211-contam.fasta]
  • DUG2 SGDID:S000000485, Chr II from 767606-764970, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" [20141208_orf_trans.fasta]
  • YBR281C SGDID:S000000485, Chr II from 767606-764970, Genome Release 64-1-1, reverse complement, Verified ORF, "Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 878 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glutathione catabolic process [IMPLink to PubMed article]
    Molecular Function: X-His dipeptidase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYDSRGVALH SELIHRWNHA FSILSIVAFP KKRLLFAGSQ DSKILVFDLP TYNLIHTIRL  60
   61 GESQEETHTR SSVLCLTGSE DENFLFSGGA DSLVRIWSIG EKTIRDDFLP VTEIATVYSV 120
  121 TDIGDIFSLA YLDSLETIVF GCQNASLLYV ENLIQKIEKK SSDGVENINK LPHRRYDKFF 180
  181 DSLGPTGYSS NSLSQTSLTS LQENCGAAII EVPSENIIKY AHYGFIYSIN KLCPRFNQLL 240
  241 EKSSRTSGAE HIISSAGDGI SKLWEFSKDK GQNTVKISLI NDKIDNEDSV ISQTIEFPFL 300
  301 YCGLTDGIIK IWDLNTQQII STLKTKHESD VISISVYMDH VFAIDESGIT HFYQNQVNHW 360
  361 NPQQGKILSS EIFSKSNAGS VSLLTGGSDG SLTLWDITSL LSAVPLSSNS PINASSTLQT 420
  421 TNLWAAYQSA SLNNEEMLNT LRELISFQTV SQSKDTTNTL SLRRCAIYLQ QLFLKFGATN 480
  481 SQLFPLPDGG NPVVFAYFQG NGKVSQVKGA KKKRILWYGH YDVISSGNTF NWNTDPFTLT 540
  541 CENGYLKGRG VSDNKGPLVS AIHSVAYLFQ QGELVNDVVF LVEGSEEIGS ASLKQVCEKY 600
  601 HDIIGKDIDW ILLSNSTWVD QEHPCLNYGL RGVINAQIKV WSDKPDGHSG LNGGVYDEPM 660
  661 VNLVKIVSKL QNEQNEIMIP NFYSPLKDLT EEEYQRFQKI TELANIDENT TVQDLITNWT 720
  721 KPSLSMTTVK FSGPGNITVI PKSVTMGISI RLVPEQSVEQ VKRDLKAYLE ESFKQLKSQN 780
  781 HLEIKVLNEA EGWLGDPTNH AYQILKDEIT TAWDVEPLLV REGGSISCLR MLERIFDAPA 840
  841 VQIPCGQSTD NGHLANENLR IKNWSNLTEI LSKVFNRL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC15 DUG2 TEM1
    View Details Krogan NJ, et al. (2006) DUG2 VTH1
    View Details Ho Y, et al. (2002) ADK1 BFA1 CDC15 CDC33 CIC1 CLU1 COF1 COR1 CPR1 CPR3 CYS4 DUG2 DUT1 EFB1 ERB1 FAA4 GCD11 GUS1 KGD1 MCX1 NMD3 NUP53 PFK1 PST2 RNR1 RNR2 ROK1 SAR1 SEC53 SSD1 TEF4 TEM1 TIF1, TIF2 TMA29 UFD4 UTP10 UTP15 VMA5 YGR066C YHB1 YHR033W YNK1 YTM1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DUG2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..410] PSI-BLAST 81.221849 beta1-subunit of the signal-transducing G protein heterotrimer
    2 View Details [411..632]
    [790..878]    		 PSI-BLAST 28.69897 Carboxypeptidase G2, catalytic domain; Carboxypeptidase G2
    3 View Details [633..789] PSI-BLAST 28.69897 Carboxypeptidase G2, catalytic domain; Carboxypeptidase G2


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle