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Protein Overview: SKT5

General Information:
Name(s) found: SKT5 / YBL061C [SGD]
Description(s) found:
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  • gi|6319410|ref|NP_009492.1| Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation; Skt5p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S39827 SKT5 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|536097|emb|CAA84882.1| SKT5 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|465520|sp|P34226.1|SKT5_YEAST RecName: Full=Protein SKT5 [NCBI NR]
  • gi|313737|emb|CAA80786.1| YBL0519 [Saccharomyces cerevisiae] [NCBI NR]
  • Protein SKT5 OS=Saccharomyces cerevisiae GN=SKT5 PE=1 SV=1 [Swiss-Prot]
  • SKT5 Protoplast regeneration and killer toxin resistance protein [mips]
  • Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation [SGD]
  • SKT5, Chr II from 105277-107367, reverse complement [yeast_orfs2]
  • Chr II from 105277-107367, reverse complement [yeastorf3.fasta]
  • Chr II from 107367-105277, reverse complement [yeastorf5.fasta]
  • (P34226) SKT5 protein [4932.FASTACCERV.txt]
  • SKT5 SGDID:S0000157, Chr II from 107370-105280, reverse complement, Verified ORF [yeastflysequest.fasta]
  • SKT5 SGDID:S0000157, Chr II from 107408-105318, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation [Saccharomyces cerevisiae]gi|313737|emb|CAA80786.1| YBL0519 [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • SKT5 SGDID:S000000157, Chr II from 107408-105318, reverse complement, Verified ORF, "Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YBL0519 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation; Skt5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein SKT5 [nr-271106-contam.fasta]
  • SKT5 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Protein SKT5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKT5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SKT5 SGDID:S000000157, Chr II from 107406-105316, Genome Release 64-1-1, reverse complement, Verified ORF, "Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation" [yeast-030211-contam.fasta]
  • SKT5 SGDID:S000000157, Chr II from 107406-105316, Genome Release 64-2-1, reverse complement, Verified ORF, "Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YBL061C SGDID:S000000157, Chr II from 107406-105316, Genome Release 64-1-1, reverse complement, Verified ORF, "Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 696 amino acids

    Gene Ontology:
    Cellular Component: cellular bud neck septin ring [IDALink to PubMed article]
    incipient cellular bud site [IDALink to PubMed article]
    cellular bud neck [IDALink to PubMed articleLink to PubMed article]
    Biological Process: response to osmotic stress [IMPLink to PubMed article]
    cytokinesis [IMPLink to PubMed article]
    cell wall chitin biosynthetic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: enzyme activator activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSPQVHPY KKHLMQSQHI NFDNRGLQFQ NSSLKVGQDF SDNKENRENR DNEDFSTADL  60
   61 PKRSANQPLI NEHLRAASVP LLSNDIGNSQ EEDFVPVPPP QLHLNNSNNT SLSSLGSTPT 120
  121 NSPSPGALRQ TNSSTSLTKE QIKKRTRSVD LSHMYLLNGS SDTQLTATNE SVADLSHQMI 180
  181 SRYLGGKNNT SLVPRLKTIE MYRQNVKKSK DPEVLFQYAQ YMLQTALTIE SSNALVQDSD 240
  241 KEGNVSQSDL KLQFLKEAQS YLKKLSIKGY SDAQYLLADG YSSGAFGKIE NKEAFVLFQA 300
  301 AAKHGHIESA YRASHCLEEG LGTTRDSRKS VNFLKFAASR NHPSAMYKLG LYSFYGRMGL 360
  361 PTDVNTKLNG VKWLSRAAAR ANELTAAAPY ELAKIYHEGF LDVVIPDEKY AMELYIQAAS 420
  421 LGHVPSATLL AQIYETGNDT VGQDTSLSVH YYTQAALKGD SVAMLGLCAW YLLGAEPAFE 480
  481 KDENEAFQWA LRAANAGLPK AQFTLGYFYE HGKGCDRNME YAWKWYEKAA GNEDKRAINK 540
  541 LRSRDGGLAS IGKKQHKKNK SISTLNLFST VDSQTSNVGS NSRVSSKSET FFTGNPKRDR 600
  601 EPQGLQINMN SNTNRNGIKT GSDTSIRKSS SSAKGMSREV AEQSMAAKQE VSLSNMGSSN 660
  661 MIRKDFPAVK TESKKPTSLK NKKDKQGKKK KDCVIM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BBC1 PPR1 SKT5 UBP7
    View Details Gavin AC, et al. (2006) ASC1 RPL27B SKT5
    View Details Ho Y, et al. (2002) MER1 NUM1 PAA1 PTC4 SEF1 SKT5 SPT16 SYF1 TPS1 VHS1
    View Details Qiu et al. (2008) BNI4 CDC24 SKT5 TPM2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SKT5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] deduced N/A No confident structure predictions are available.
    2 View Details [107..220] PSI-BLAST 6.154902 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    3 View Details [221..289] PSI-BLAST 6.154902 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    4 View Details [290..379] PSI-BLAST 6.154902 Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
    5 View Details [380..424] PSI-BLAST 2.69897 TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5
    6 View Details [425..552] PSI-BLAST 2.69897 TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5
    7 View Details [553..696] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle