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Protein Overview: HIR1

General Information:
Name(s) found: HIR1 / YBL008W [SGD]
Description(s) found:
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  • gi|6319463|ref|NP_009545.1| Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional [NCBI NR]
  • pir||S41218 HIR1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|535992|emb|CAA84827.1| HIR1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1680406|gb|AAB23989.1|S47695_3 YBL03-18 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|110282967|sp|P32479.2|HIR1_YEAST RecName: Full=Protein HIR1; AltName: Full=Histone transcription regulator 1 [NCBI NR]
  • Protein HIR1 OS=Saccharomyces cerevisiae GN=HIR1 PE=1 SV=2 [Swiss-Prot]
  • HIR1 Histone transcription regulator [mips]
  • Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores [SGD]
  • HIR1, Chr II from 209614-212136 [yeast_orfs2]
  • Chr II from 209614-212136 [yeastorf3.fasta]
  • HIR1 SGDID:S0000104, Chr II from 209618-212140, Verified ORF [yeastflysequest.fasta]
  • HIR1 SGDID:S0000104, Chr II from 209656-212178, Verified ORF [10112005cervSGD.fasta]
  • Hir1p [Saccharomyces cerevisiae]gi|535992|emb|CAA84827.1| HIR1 [Saccharomyces cerevisiae]gi|1680406|gb|AAB23989.1| YBL03-18 [Saccharomyces cerevisiae]gi|626178|pir||S41218 HIR1 protein - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • HIR1 SGDID:S000000104, Chr II from 209656-212178, Verified ORF, "Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene s [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • HIR1 SGDID:S000000104, Chr II from 209656-212178, Verified ORF, "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and forma [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • HIR1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YBL03-18 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Histone transcription regulator 1 [nr-271106-contam.fasta]
  • Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores; Hir1p [Saccha [nr-271106-contam.fasta]
  • HIR1 SGDID:S000000104, Chr II from 209656-212178, Verified ORF, "Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores" [yeast-bovrabprots.fasta]
  • HIR1 SGDID:S000000104, Chr II from 209656-212178, Verified ORF, "Non-essential transcriptional corepressor involved in the cell cycle-regulated transcription of histone H2A, H2B, H3 and H4 genes; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 840 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    HIR complex [IDALink to PubMed article]
    chromosome, centromeric region [IDALink to PubMed article]
    Biological Process: DNA replication-independent nucleosome assembly [IDALink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IGILink to PubMed article]
    Molecular Function: transcription corepressor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVVKFPWLA HREESRKYEI YTVDVSHDGK RLATGGLDGK IRIWSIDSIL RCMELESLTP  60
   61 EIPLPQDLQM PLCSMSRHTG SITCVKFSPD GKYLASGSDD RILLIWALDE EQSSQPAFGS 120
  121 EHEREHWTVR KRLVAHDNDI QDICWAPDSS ILVTVGLDRS VIVWNGSTFE KLKRFDVHQS 180
  181 LVKGVVFDPA NKYFATTSDD RTMKIFRYHK TGDISFTIEH IITEPFKESP LTTYFRRPSW 240
  241 SPDGQHIAVP NATNGPVSSM AIVNRGTWDT NVSLIGHDAP TEVARFNPRL FERNAGVKQK 300
  301 KDDDPENALV GQNDDKVHHF DKNIDSVVAT AGQDKSLAVW STSRPRPILV AFDIANKSIT 360
  361 DMSWNPDGSL LFVASLDSSI TLFKFENNEL GKPIPLEKNM EQLYRYGVDK DSLDFPESIN 420
  421 QLLLEDQTKS FKHTKISTSK LGENHPTLAT NSASNQKDNN DASVSRSEHI NILIPKRKKD 480
  481 AILNKAVTLK SGKKRVAPTL ISTSSSSPFS NGIKKPTLDS KRIENNVKSS TKTINSKNTL 540
  541 LNVPEGVEKK ISISSFPLPR LGIHSLIMGT KERSAWKISN SELENDDADN AGGKGSDGTS 600
  601 NSIDDIAVLS EEENDFHRMT LNAKLTQEKI WSEEPTTRCL LQSDVIPDTD VVVLEGGSLD 660
  661 DIAVLEIRNG VERSIQFDSE ALLDNPTRIL GYQGGKRTIE TFIPEVIICA IGSKDCKCWC 720
  721 LASANGSIYI LSYNGQQRIP KICLGHKVIK MVTSSKYLLV LTERGLFFAW DLLDLKLVLR 780
  781 NVPILPILNG QPIHGNKVRI NKVIKCFRLD GSSCDLLLEV GDPKNVYKWT KDLGCWSLYK 840
  841

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ASF1 HIR1 HIR2 HPC2
    View Details Krogan NJ, et al. (2006) ASF1 HIR1 HIR2 HIR3 HPC2 QDR2 SFP1
    View Details Ho Y, et al. (2002) BRX1 BUD3 CCT2 CCT3 CCT6 CIN8 CLU1 HIR1 HTB1 KRE33 MNP1 NAN1 NOP56 POL5 RRP12 RVB1 SSD1 TIF4631 TMA19 UTP10 UTP22 UTP7
    View Details Qiu et al. (2008) ASF1 CAC2 HIR1 HIR2 HIR3 HPC2 MSI1 RLF2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run HIR2 No Comments Green EM, et al (2005)
    View Run ASF1 sample 3121 run on DecaLCQ: searched for phosphorylation Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data HIR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] PSI-BLAST 130.67837 beta1-subunit of the signal-transducing G protein heterotrimer
    2 View Details [78..130] PSI-BLAST 142.38764 Tup1, C-terminal domain
    3 View Details [131..535] PSI-BLAST 2.221849 Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2
    4 View Details [536..607] deduced N/A No confident structure predictions are available.
    5 View Details [608..840] MSA 4.130997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
    		• 6.67009948605948 bayes_pls_golite062009
  • snoRNA binding
    		•  4.78410616474982 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.79445416141967 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • dynein binding
    		•  1.74989209255308 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • structural molecule activity
    		•  1.31060431370834 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19593750149343 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • actin binding
    		•  0.529861581509437 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
    3
    Term Confidence Notes
    		• 6.67009948605948 bayes_pls_golite062009
  • snoRNA binding
    		•  4.78410616474982 bayes_pls_golite062009
  • RNA binding
    		•  3.77273677738815 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.79445416141967 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.29049708962212 bayes_pls_golite062009
  • dynein binding
    		•  1.74989209255308 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.41752877005447 bayes_pls_golite062009
  • structural molecule activity
    		•  1.31060431370834 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19593750149343 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • mRNA binding
    		•  1.05053985350578 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.625780732991652 bayes_pls_golite062009
  • actin binding
    		•  0.529861581509437 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.220747580531792 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle