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Protein Overview: FBpp0311517, Gpr...

General Information:
Name(s) found: FBpp0311517 [FlyBase]
Gprk1-PB / FBpp0291451 [FlyBase]
Gprk1-PA / FBpp0110413 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • type=protein; loc=2R:complement(210038..210220,210281..210443,223882..224088,238054..238272,238623..238723,265874..266200,266254..266409,266469..266660,295486..295537,315441..315502,345528..345602,345659..345760,345812..345885,345946..346022,358275..358387); ID=FBpp0311517; name=Gprk1-PC; parent=FBgn0260798,FBtr0345363; dbxref=FlyBase:FBpp0311517,FlyBase_Annotation_IDs:CG40129-PC; MD5=e5928496f0ee647d5c1600fb80869f80; length=700; release=r5.56; species=Dmel; [FlyBase]
  • The gene G protein-coupled receptor kinase 1 is referred to in FlyBase by the symbol Dmel\Gprk1 (CG40129, FBgn0260798). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:209942..358573. It has the cytological map location 41B3-41C2. There is experimental evidence that it has the molecular function</span>: G-protein-coupled receptor binding; ATP binding; phosphoinositide binding; rhodopsin kinase activity. There is experimental evidence that it is involved in the biological process</span>: protein amino acid phosphorylation; phototransduction, visible light; metarhodopsin inactivation. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene G protein-coupled receptor kinase 1 is referred to in FlyBase by the symbol Dmel\Gprk1 (CG40129, FBgn0260798). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:209942..358573. It has the cytological map location 41B3-41C2. There is experimental evidence that it has the molecular function</span>: G-protein-coupled receptor binding; ATP binding; phosphoinositide binding; rhodopsin kinase activity. There is experimental evidence that it is involved in the biological process</span>: protein amino acid phosphorylation; phototransduction, visible light; metarhodopsin inactivation. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 700 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: phototransduction, visible light [IMP]
    metarhodopsin inactivation [IMP]
    G-protein coupled receptor protein signaling pathway [NAS]
    signal transduction [ISS]
    regulation of G-protein coupled receptor protein signaling pathway [ISS]
    protein amino acid phosphorylation [IMP][ISS][NAS]
    Molecular Function: G-protein-coupled receptor binding [IPI]
    ATP binding [IMP]
    rhodopsin kinase activity [IMP]
    G-protein coupled receptor kinase activity [IEA][ISS][NAS]
    phosphoinositide binding [IDA]
    protein serine/threonine kinase activity [NAS]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADLEAVLAD VSYLMAMEKS KCTPAARASK KLNLPDPSVR SVMYKYLEKE GELNFHKIFN  60
   61 EVLGYLLFKD FCENDSEEPI QQLKFFEQIK LFEKTECYDE RKKMARDIYD NFIMEEMLSH 120
  121 TYEYSKHAVA SVQKYLLKNE VPVDLFEPYL EEIFTQLKGK PFKKFLESDK FTRFCQWKNL 180
  181 ELNIQLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGEMLALNER 240
  241 NMLQAVSTGI DCPFIVCMTY AFHTPDKLCF ILDLMNGGDL HYHLSQHGIF SEDEMKFYAA 300
  301 EVILGLEHMH KRCIVYRDLK PANILLDENG HIRISDLGLA CDFSKKKPHA SVGTHGYMAP 360
  361 EVLSKGTSYD SCADWFSFGC MLYKLLKGHS PFRQHKTKDK LEIDKMTLTM NVELPESFSL 420
  421 ELKNLLEMLL QRDVSKRLGC MGNGADEVKM HNFFCGIDWH QVYIQKYTPP LVPPRGEVNA 480
  481 ADAFDIGSFD EEDTKGIKLN DADQDLYKMF SLTISERWQQ EVSETVFDTV NTETDKLEQK 540
  541 RKLKQKQHFD ADEKESDCIL HGYIKKLGGS FASLWQTKYA KLYPNRLELH SESGNNKPEL 600
  601 IFMDQVEDIS SDFILHKNEN CIQIRINDGT RDGRIILTNS DEIGLKEWSS SLRSAHKISQ 660
  661 DLLGSMAKKA GKIYGSERDV NKSMYIFGGN CSTKTSNGSN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..700] PSI-BLAST 149.0 G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • insulin receptor activity
    		•  3.256741381527 bayes_pls_golite062009
  • SH2 domain binding
    		•  3.03401803018883 bayes_pls_golite062009
  • PTB domain binding
    		•  3.02789234463297 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • tau-protein kinase activity
    		•  2.37138140221719 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  2.18795259566024 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • armadillo repeat domain binding
    		•  1.70850996351356 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.34841233233438 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.33825339298024 bayes_pls_golite062009
  • brain-derived neurotrophic factor binding
    		•  1.28495809513039 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • insulin binding
    		•  1.23861703046323 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.19908793854422 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.07023555877478 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.965872107791437 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.886904175966993 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  0.856861384729301 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • profilin binding
    		•  0.66906205737225 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • Janus kinase activity
    		•  0.580310109637219 bayes_pls_golite062009
  • I-SMAD binding
    		•  0.568054578050901 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.28468123649303 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • photoreceptor activity
    		•  0.187612589250841 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • alpha-catenin binding
    		•  0.102004310679969 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.0405961152540697 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle