Protein Overview: nep-1

General Information:
Name(s) found:	nep-1 / CE39118 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00013926 locus:nep-1 Neprilysin-1 status:Partially_confirmed UniProt:Q18673 protein_id:CAA93782.2 [WormBase] gi\|86562497\|ref\|NP_496490.2\| NEPrilysin metallopeptidase family member (nep-1) [Caenorhabditis elegans] [NCBI NR] gi\|74834815\|emb\|CAA93770.2\| C. elegans protein ZK20.6, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|74834639\|emb\|CAA93782.2\| C. elegans protein ZK20.6, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|114152088\|sp\|Q18673.3\|NEPL1_CAEEL RecName: Full=Neprilysin-1 [NCBI NR] Neprilysin-1 OS=Caenorhabditis elegans GN=nep-1 PE=1 SV=3 [Swiss-Prot] CE39118 WBGene00013926 locus:nep-1 neprilysin status:Partially_confirmed TR:Q18673 protein_id:CAA93782.2 [wormpep150.fasta] 39118 WBGene00013926 locus:nep-1 neprilysin status:Partially_confirmed TR:Q18673 protein_id:CAA93782.2 [wormpep150-phg-orf-ecoli-rand.fasta] CE39118 WBGene00013926 locus:nep-1 neprilysin status:Partially_confirmed UniProt:Q18673 protein_id:CAA93782.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE39118 WBGene00013926 locus:nep-1 neprilysin status:Partially_confirmed UniProt:Q18673 protein_id:CAA93782.2\| [wormORF-contam.fasta] Hypothetical protein ZK20.6 [Caenorhabditis elegans] [nr-271106-contam.fasta] Neprilysin-1 [nr-271106-contam.fasta] ZK20.6 [Caenorhabditis elegans] [nr-271106-contam.fasta] CE39118 WBGene00013926 locus:nep-1 neprilysin status:Partially_confirmed SW:Q18673 protein_id:CAA93782.2 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE39118 WBGene00013926 locus:nep-1 status:Partially_confirmed UniProt:Q18673 protein_id:CAA93782.2 Neprilysin-1 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	754 amino acids
Gene Ontology:
Cellular Component:	membrane [IEA]
Biological Process:	proteolysis [IEA] reproduction [IMP]
Molecular Function:	zinc ion binding [IEA] neprilysin activity [IEA] metallopeptidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTRFGPPIV FLISCYALIL CGTVDALPRA PYFNDDINKT TTTSEDKTVG NTVVEEEKKT  60
   61 YTVGDSEGYQ EASRLLQKSL NLSLDPCDDF FEYACRAWVD SHPIPDDLTS YSQFTATREK 120
  121 VLAEMRKLYE DNTSIPTSKS IALIKQIYNT CMDTEKHNAV GARDLLEKIK TYGYWPMVHN 180
  181 EKWRESTFDL TKLLSNTIQS RDVSVFFDFG PAEDSRNVSR RLLSFDQGSL GLGYSTRDYY 240
  241 LDEKKYEKQM KAYRKYTIGK VRYYTEDAGM AVNESKIESD VDEIIAFEKE WAQILVAEED 300
  301 RRNYTKLYNV RRFDDLKEYM SIIDWKKLTL STTPFLVHSY LKTNPSIIIS DVEYLQKMNT 360
  361 LLQNTDPRIV TNYILLRWAG SWSQEIGKKY EDLQQEFAFQ MYGRKQRQPR WKDCVSSAGG 420
  421 KLSYASGSMY VRKYFDANAK NTTLDMITDL QEAFRNMMHA NDWMDAETKK YALEKADQML 480
  481 KQIGYPDFIL NDEKLDDWYK GLEGAPEDSF SQLVEKSIQW RNNFYYRRLL EPVNRFEFIS 540
  541 SAAVVNAFYS PTRNAIAFPA GILQQPFFDA RFPKALNYGG IGAVIGHEIT HGFDDTGRQF 600
  601 DNVGNLRDWW DNTTSSKFNE RTQCIIEQYA DVKLRGTDLR INGKLTQGEN IADNGGIKQA 660
  661 FKAYKSYLEK HGGQEARLPQ FESLTNEQLF FVGYAQVWCG AKTPETKTLL LLTDPHSPET 720
  721 ARVNTVLTNQ PEFAEAFKCP AGSPMNPTKR CVVW

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
peptidase activity	5.33358263548929	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	4.99457783001146	bayes_pls_golite062009
bradykinin receptor binding	4.68498310889748	bayes_pls_golite062009
endopeptidase activity	4.16532996235931	bayes_pls_golite062009
metallopeptidase activity	3.94798058866011	bayes_pls_golite062009
metalloendopeptidase activity	3.43236442601127	bayes_pls_golite062009
peptidyl-dipeptidase activity	3.15882456934259	bayes_pls_golite062009
hydrolase activity	2.61181165622708	bayes_pls_golite062009
angiotensin receptor activity	2.47329778652768	bayes_pls_golite062009
G-protein coupled receptor activity	2.40931483220122	bayes_pls_golite062009
exopeptidase activity	2.07461908743946	bayes_pls_golite062009
receptor binding	2.07222569254168	bayes_pls_golite062009
transmembrane receptor activity	1.71636138555452	bayes_pls_golite062009
receptor activity	1.71573921458029	bayes_pls_golite062009
peptide binding	1.58227634414618	bayes_pls_golite062009
protein binding	1.58118182554863	bayes_pls_golite062009
binding	1.55761777216628	bayes_pls_golite062009
molecular transducer activity	1.42071856700201	bayes_pls_golite062009
signal transducer activity	1.42071856700201	bayes_pls_golite062009
viral receptor activity	1.39617252453036	bayes_pls_golite062009
epoxide hydrolase activity	1.37998417474643	bayes_pls_golite062009
ether hydrolase activity	1.18753073809881	bayes_pls_golite062009
protein complex binding	1.16270782056592	bayes_pls_golite062009
integrin binding	0.93449223670512	bayes_pls_golite062009
catalytic activity	0.891187593353827	bayes_pls_golite062009
interleukin-6 receptor binding	0.711782218042781	bayes_pls_golite062009
cytokine receptor binding	0.61233964043845	bayes_pls_golite062009
peptide receptor activity, G-protein coupled	0.597899738932066	bayes_pls_golite062009
peptide receptor activity	0.574641388356132	bayes_pls_golite062009
zinc ion binding	0.49304764842799	bayes_pls_golite062009
hydrolase activity, acting on ether bonds	0.457157426475929	bayes_pls_golite062009
serine hydrolase activity	0.393080846858665	bayes_pls_golite062009
serine-type peptidase activity	0.374597710524442	bayes_pls_golite062009
growth factor activity	0.259654587796416	bayes_pls_golite062009
serine-type endopeptidase activity	0.252655558968584	bayes_pls_golite062009
aminopeptidase activity	0.21808506596674	bayes_pls_golite062009
transition metal ion binding	0.21514043665594	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..754]	PSI-BLAST	1000.0	Neutral endopeptidase (neprilysin)

Protein Overview: nep-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: